Effect of melatonin pre-intervention on expression of thioredoxin-2 in pancreatic tissue of rats with acute necrotizing pancreatitis: Implications for protective effects of melatonin

2015 ◽  
Vol 23 (4) ◽  
pp. 596
Author(s):  
Hui Zhao
2007 ◽  
Vol 13 (46) ◽  
pp. 6172 ◽  
Author(s):  
Oge Tascilar ◽  
Güldeniz Karadeniz Cakmak ◽  
Ishak Ozel Tekin ◽  
Ali Ugur Emre ◽  
Bulent Hamdi Ucan ◽  
...  

Author(s):  
Sonia Gupta

Necrotizing pancreatitis is an extreme complication of acute pancreatitis. Acute pancreatitis is an inflammation of the pancreas. Pancreas sits behind the stomach. One of its main functionsis to make enzymes that help in digest the food. Normally, those enzymes flow through a small opening into small intestines. If pancreas becomes inflamed, the enzymes can start to leak into parts of the pancreas instead. These enzymes can sometimes kill pancreatic tissue, resulting in necrotizing pancreatitis. The dead tissue can get infected and cause life-threatening complications. Cardinal symptoms are abdominal pain (boring nature), nausea, vomiting, and tenderness in abdomen, pain worsened after eating, steatorrhea and weight loss. Assessments were made using Elevated levels of Serum Amylase and Lipase. In modern science, management is Lifelong enzymes, Periodical Emergency hospitalisation, IV fluids, painkillers, anti-inflammatory, andantibiotics, ERCP stunting, surgical intervention. It involves high cost, side effects and in many cases, there is progression of disease leading to fear, frustration and debility among sufferers. In Ayurveda three doshas are described as Vata, Pitta, Kapha.  Pitta dosha we have substances exactly similar to enzymes. The features of acute pancreatitis are similar to the features of pitta where tikshna and ushna guna of pitta are aggravated. The observations reveal that, Ayurvedic regimen can play a key role in the management of conditions like pancreatitis. A 25years old male patient diagnosed with acute necrotizing pancreatitis. At the end of the treatment, there was considerable improvement in the subjective and objective criterias. The treatment strategies followed in this study can be safely adopted under the supervision of competent specialist.


2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
I. Kovalska ◽  
O. Dronov ◽  
S. Zemskov ◽  
E. Deneka ◽  
M. Zemskova

Acinar necrosis is the basic microscopic sign of acute necrotizing pancreatitis (ANP). Microcirculation disorder is one of the major factors in the pathogenesis and morphogenesis of ANP besides free radicals and damage of enzymatic origin. This study is dedicated to the description of microscopic changes in the pancreatic stroma in ANP, which leads to destruction of the exocrine pancreas with a putative mechanism of endocrine function preservation. This study has been carried out on histological samples of pancreas from 224 patients with ANP. Histological staining was performed with hematoxylin-eosin (H&E), Masson, Gomori methods, and PAS. Microscopy was performed with magnifications of 40×, 100×, and 400×. Vascular endothelial desquamation, stasis, and sludge are typical changes in microcirculation observed in early stages of ANP. Initially, parietal circular intravascular microthrombosis accompanied by endothelial desquamation as early as stromal swelling occurs with no detectable necrosis. Residual stroma appears between areas of necrosis and intact pancreatic tissue. Mucoid swelling is first seen in the perivascular spaces extending to the parenchyma and changing into fibrinoid imbibition causing further necrosis. Reticulin argyrophilic backbone surrounding the pancreatic acini and small ducts decompose. Pancreatic structures, which may be preserved in necrotic tissue, include nerves, major ducts, and Langerhans islets.


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