Abstract C111: Pediatric Preclinical Testing Program (PPTP): Evaluation of the MEK1/2 inhibitor AZD6244 against juvenile pilocytic astrocytoma (JPA) xenografts

✓ The authors give follow-up information on Case 59 of Cushing's 1931 series of cerebellar astrocytomas. The patient died with a malignant cerebellar astrocytoma 48 years after partial removal of a previously benign astrocytoma at the same site. Including the present one, there have been only five reported cases in which this has occurred. Ordinarily, juvenile pilocytic astrocytomas are of extremely benign character, and it is well established that even with incomplete resections patients have survived for years without progression of the tumor. Not all of the cases so reported can be wholly accepted as representing malignant transformation of the tumor, but may instead be instances of recurrence of an inherently benign glioma since the presence of features such as endothelial hyperplasia or nuclear atypicality in a juvenile pilocytic astrocytoma does not warrant its being classified as malignant. Features truly suggestive of malignancy are hypercellularity, frequent mitoses, necrosis, and, in some instances, a diffusely infiltrative growth pattern; all of these features were found in the present case.

Download Full-text

Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

Pediatric Blood & Cancer ◽

10.1002/pbc.23290 ◽

2011 ◽

Vol 58 (5) ◽

pp. 815-818 ◽

Cited By ~ 22

Author(s):

E. Anders Kolb ◽

Richard Gorlick ◽

Stephen T. Keir ◽

John M. Maris ◽

Richard Lock ◽

...

Keyword(s):

Notch Signaling ◽

Preclinical Testing ◽

Testing Program ◽

Initial Testing ◽

Secretase Inhibitor ◽

Testing Stage ◽

Stage 1

Download Full-text

Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program

Pediatric Blood & Cancer ◽

10.1002/pbc.23159 ◽

2011 ◽

Vol 58 (4) ◽

pp. 566-571 ◽

Cited By ~ 21

Author(s):

Christopher L. Morton ◽

John M. Maris ◽

Stephen T. Keir ◽

Richard Gorlick ◽

E. Anders Kolb ◽

...

Keyword(s):

Childhood Cancer ◽

Preclinical Testing ◽

Testing Program ◽

Cancer Models

Download Full-text

Initial testing (stage 1) of glembatumumab vedotin (CDX-011) by the pediatric preclinical testing program

Pediatric Blood & Cancer ◽

10.1002/pbc.25099 ◽

2014 ◽

Vol 61 (10) ◽

pp. 1816-1821 ◽

Cited By ~ 22

Author(s):

E. Anders Kolb ◽

Richard Gorlick ◽

Catherine A. Billups ◽

Thomas Hawthorne ◽

Raushan T. Kurmasheva ◽

...

Keyword(s):

Preclinical Testing ◽

Testing Program ◽

Initial Testing ◽

Testing Stage ◽

Stage 1

Download Full-text

Peduncular Hallucinosis as First Presentation of Juvenile Pilocytic Astrocytoma

The Indian Journal of Pediatrics ◽

10.1007/s12098-015-1935-8 ◽

2015 ◽

Vol 83 (7) ◽

pp. 736-737 ◽

Cited By ~ 2

Author(s):

Sugata Narayan Biswas ◽

Souvik Biswas ◽

Partha Pratim Chakraborty

Keyword(s):

Pilocytic Astrocytoma ◽

Juvenile Pilocytic Astrocytoma ◽

Peduncular Hallucinosis

Download Full-text

Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver–Russell syndrome

British Journal of Neurosurgery ◽

10.1080/02688690802044076 ◽

2008 ◽

Vol 22 (6) ◽

pp. 776-777 ◽

Cited By ~ 6

Author(s):

E. Fenton ◽

D. Refai ◽

W. See ◽

D. J. Rawluk

Keyword(s):

Young Adult ◽

Pilocytic Astrocytoma ◽

Juvenile Pilocytic Astrocytoma ◽

Silver Russell Syndrome

Download Full-text

Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child

Journal of Neurosurgery Pediatrics ◽

10.3171/2009.9.peds09211 ◽

2010 ◽

Vol 5 (2) ◽

pp. 149-154 ◽

Cited By ~ 3

Author(s):

Andrew Jea ◽

Ernesto Coscarella ◽

Murali Chintagumpala ◽

Meena Bhattacharjee ◽

William E. Whitehead ◽

...

Keyword(s):

Brain Tumors ◽

Mr Imaging ◽

Pilocytic Astrocytoma ◽

Cell Types ◽

Cerebellar Hemisphere ◽

Pathological Examination ◽

Primary Brain Tumors ◽

Juvenile Pilocytic Astrocytoma ◽

Multiple Primary ◽

Different Cell Types

Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature. However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare. Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types. The authors describe the case of an 8-year-old boy who presented with a 2-week history of progressive headache, nausea and vomiting, and imbalance. Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis. Spinal MR imaging was unremarkable. The patient underwent a suboccipital craniotomy and subsequent gross-total resection of both mass lesions. Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively. The patient did well in the immediate postoperative period, was discharged home, and underwent neurooncological follow-up. To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors. They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.

Download Full-text