Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

2019 ◽  
Author(s):  
Mark J. O'Connor ◽  
Cristina Cruz ◽  
Marta Castroviejo-Bermejo ◽  
Urszula M. Polanska ◽  
Gemma N. Jones ◽  
...  
Keyword(s):  
Stress Response ◽  
Parp Inhibitor ◽  
Replication Stress ◽  
Inhibitor Resistance

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

2019 ◽  
Author(s):  
Mark J. O'Connor ◽  
Cristina Cruz ◽  
Marta Castroviejo-Bermejo ◽  
Urszula M. Polanska ◽  
Gemma N. Jones ◽  
...  
Keyword(s):  
Stress Response ◽  
Parp Inhibitor ◽  
Replication Stress ◽  
Inhibitor Resistance

Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1-Deficient Cells by Increasing DNA Replication Stress

2020 ◽  
Author(s):  
Mariana Paes Dias ◽  
Vivek Tripathi ◽  
Ingrid van der Heijden ◽  
Ke Cong ◽  
Eleni-Maria Manolika ◽  
...  
Keyword(s):  
Dna Replication ◽  
Nuclear Dna ◽  
Parp Inhibitor ◽  
Replication Stress ◽  
Dna Ligase ◽  
Dna Replication Stress ◽  
Inhibitor Resistance ◽  
Dna Ligase Iii

Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

2014 ◽  
Author(s):  
Shiaw-Yih Lin ◽  
Chun-Jen Lin ◽  
Lili Gong ◽  
Hui Dai ◽  
Ju-Seog Lee
Keyword(s):  
Breast Cancer ◽  
Stress Response ◽  
Replication Stress

scholarly journals RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

2016 ◽  
Vol 26 (24) ◽  
pp. 3257-3268 ◽  
Author(s):  
Yuan-Cho Lee ◽  
Qing Zhou ◽  
Junjie Chen ◽  
Jingsong Yuan
Keyword(s):  
Dna Replication ◽  
Stress Response ◽  
Binding Protein ◽  
Replication Stress ◽  
Dna Replication Stress

scholarly journals Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy

2017 ◽  
Vol 4 (6) ◽  
pp. e1360978 ◽  
Author(s):  
Xiaolei Pan ◽  
Naveed Ahmed ◽  
Joyce Kong ◽  
Dong Zhang
Keyword(s):  
Stress Response ◽  
Cancer Therapy ◽  
Replication Stress

Abstract SP084: Replication stress response defects predict responses to ICT in non-hypermutated tumors

2021 ◽  
Author(s):  
D McGrail ◽  
P Pilié ◽  
XHF Zhang ◽  
J Rosen ◽  
L Voorwerk ◽  
...  
Keyword(s):  
Stress Response ◽  
Replication Stress

scholarly journals FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

2017 ◽  
Vol 45 (20) ◽  
pp. 11837-11857 ◽  
Author(s):  
Elizabeth L. Thompson ◽  
Jung E. Yeo ◽  
Eun-A Lee ◽  
Yinan Kan ◽  
Maya Raghunandan ◽  
...  
Keyword(s):  
Stress Response ◽  
Replication Stress ◽  
Independent Functions ◽  
Cellular Replication

scholarly journals A new role for a tumor-suppressing protein

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Jeremy S Setton ◽  
Simon N Powell
Keyword(s):  
Dna Repair ◽  
Stress Response ◽  
Replication Stress ◽  
Repair Process ◽  
Protein P53

In addition to its role in preventing tumors, the protein p53 appears to participate in a DNA repair process known as the replication-stress response.

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