Abstract PD3-8: Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients

2015 ◽  
Author(s):  
Francois-Clement Bidard ◽  
Jordan Madic ◽  
Anna Kiialainen ◽  
Fabian Birzele ◽  
Guillemette Ramey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Circulating Tumor Dna ◽  
Breast Cancer Patients ◽  
Tumor Dna

scholarly journals Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients

2014 ◽  
Vol 136 (9) ◽  
pp. 2158-2165 ◽  
Author(s):  
Jordan Madic ◽  
Anna Kiialainen ◽  
Francois-Clement Bidard ◽  
Fabian Birzele ◽  
Guillemette Ramey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Circulating Tumor Dna ◽  
Breast Cancer Patients ◽  
Tumor Dna

scholarly journals Phenotypic characterization of circulating tumor cells in triple negative breast cancer patients

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 5309-5322 ◽  
Author(s):  
Sofia Agelaki ◽  
Melina Dragolia ◽  
Harris Markonanolaki ◽  
Saad Alkahtani ◽  
Christos Stournaras ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Phenotypic Characterization ◽  
Breast Cancer Patients

Monitoring of circulating tumor DNA in metastatic triple-negative breast cancer patients undergoing chemotherapy.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e22056-e22056
Author(s):  
Jordan Madic ◽  
Anna Kiialainen ◽  
Francois-Clement Bidard ◽  
Fabian Birzele ◽  
Guillemette Ramey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Circulating Tumor Dna ◽  
Breast Cancer Patients ◽  
Tumor Dna

scholarly journals Concurrent Detection of Circulating Tumor Cells and Circulating Tumor DNA in Triple-negative Breast Cancer

2021 ◽  
Vol 6 (4) ◽  
pp. 373-377
Author(s):  
Henry L Gomez ◽  
Carlos A. Castaneda ◽  
Miluska Castillo ◽  
James Reuben ◽  
Hui Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Pik3ca Mutation ◽  
Digital Pcr ◽  
Circulating Tumor Dna ◽  
Pik3ca Mutations ◽  
Tumor Dna

Objective: Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) provide tumor information in breast cancer. Our objective was to characterize CTCs, and contrasted them with ctDNA PIK3CA mutation in 24 triple-negative breast cancer (TNBC). Methods: CTCs genes were characterized by AdnaTest protocol and ctDNA by digital PCR. Results:  We found CTCs genes in 37.5% and ctDNA PIK3CA mutations in 29.16%. Three cases with CTCs genes had concurrent ctDNA PIK3CA mutations. MUC1 or GA733-2 were found in 4 cases, and 3 of them had concurrent ctDNA PIK3CA. CTCs ALDH1/TWIST1 were found in 2 cases, AKT2 in one and PI3Kα in another, and none had concurrent ctDNA PIK3CA mutations. There was no correlation between CTCs and ctDNA detection. All 3 cases with CTC & cDNA concurrent finding underwent death during follow-up. Conclusion: Infrequent concurrent detection of CTC and ctDNA presence suggests that both represent independent processes in TNBC patients, and could identify worst prognosis cases.

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