Abstract PO-231: Exploring social vulnerability in locally advanced cervical cancer patients undergoing brachytherapy irradiation

2022 ◽  
Author(s):  
Lindsey A. McAlarnen ◽  
Melanie Sona ◽  
Kristin Tischer ◽  
Christina Small ◽  
Meena Bedi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Social Vulnerability ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer

scholarly journals Oncothermia in HIV-Positive and -Negative Locally Advanced Cervical Cancer Patients in South Africa

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Carrie A. Strauss ◽  
Jeffrey A. Kotzen ◽  
Ans Baeyens ◽  
Irma Maré
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Standard Treatment ◽  
Locally Advanced ◽  
External Beam Radiation ◽  
Hiv Positive ◽  
Advanced Cervical Cancer ◽  
Treatment Toxicity ◽  
Locally Advanced Cervical Cancer

Aim. Investigate the clinical, economic, and cellular effects of the addition of oncothermia to standard treatment for HIV-positive and -negative locally advanced cervical cancer patients in public healthcare in South Africa. Objectives. Evaluate the effect that the addition of oncothermia has on local disease control, progression-free survival, overall survival at 2 years, treatment toxicity, quality of life, economic impact, and HIV status of participants. Radiobiology investigations will evaluate thermoradiosensitivity and the molecular markers for thermoradiosensitivity. Methodology. Phase III randomised clinical trial involving 236 HIV-negative and -positive stage IIb-III locally advanced cervical cancer patients. Treatment includes cisplatin, external beam radiation, and brachytherapy. The study group will receive oncothermia treatments. Participants will be monitored for two years after completion of treatment. Hypothesis. The addition of oncothermia to standard treatment protocols will result in improved clinical response without increasing treatment toxicity in HIV-positive patients or raising healthcare costs.

Detection of Human Papillomavirus Types 16 and 18 mRNA in Peripheral Blood of Advanced Cervical Cancer Patients and Its Association With Prognosis

1999 ◽  
Vol 17 (5) ◽  
pp. 1391-1391 ◽  
Author(s):  
Chih-Jen Tseng ◽  
Chia C. Pao ◽  
Jen-Daw Lin ◽  
Yung-Kuei Soong ◽  
Ji-Hong Hong ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Tumor Volume ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Hpv Dna ◽  
Locally Advanced Cervical Cancer ◽  
Gene Mrna ◽  
Specific Mrna

PURPOSE: To evaluate the feasibility of detecting human papillomavirus E6 (HPVE6) gene mRNA in the peripheral blood of patients with locally advanced cervical cancer, and the relationship of the circulating HPV viral–specific mRNA with clinicopathologic factors and prognosis of locally advanced cervical cancer.PATIENTS AND METHODS: The presence of types 16 and 18 HPVE6 gene mRNA was determined by reverse transcription followed by nested polymerase chain reaction. Thirty-five patients with locally advanced cervical cancer who were positive for HPV type 16 or 18 DNA were included in the study. All patients received external-beam radiation therapy followed by intracavitary brachytherapy.RESULTS: Eighteen (51.4%) of 35 HPV DNA–positive cervical cancer patients had HPV-specific mRNA in their peripheral blood cells, compared with none of 17 HPV DNA–negative cervical cancer patients and none of 12 control volunteers. The presence of HPVE6 gene mRNA in peripheral blood was associated with bulky tumor volume (> 4 cm) and pelvic lymph node metastasis (tumor volume, P = .03; lymph node status, P = .03). After a median follow-up of 22 months, patients who were positive for peripheral-blood HPVE6 gene mRNA had a significantly higher risk of recurrence than those who were negative (10 of 18 v three of 17, P = .02; mean recurrent time, 20.7 months v 12.6 months, P = .02). There was also a statistically significant association of peripheral-blood HPVE6 gene mRNA positivity with distant metastasis (eight of 18 v one of 17; P = .01).CONCLUSION: Results of this study seem to suggest that the presence of HPVE6 gene mRNA in peripheral blood may provide an early marker that identifies patients who are at risk for metastasis.

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