Small-molecule NSC59984 induces mutant p53 degradation through a ROS-ERK2-MDM2 axis in cancer cells

2022 ◽  
pp. molcanres.MCR-21-0149-A.2021
Author(s):  
Shengliang Zhang ◽  
Lanlan Zhou ◽  
Wafik S. El-Deiry
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Mutant P53

Abstract 2472: Small-molecule-induced reactivation of mutant p53 in cancer cells.

2013 ◽  
Author(s):  
Xiangrui Liu ◽  
Rainer Wilcken ◽  
Andreas Joerger ◽  
Irina Chuckowree ◽  
John Spencer ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Mutant P53

scholarly journals Small molecule induced reactivation of mutant p53 in cancer cells

2013 ◽  
Vol 41 (12) ◽  
pp. 6034-6044 ◽  
Author(s):  
Xiangrui Liu ◽  
Rainer Wilcken ◽  
Andreas C. Joerger ◽  
Irina S. Chuckowree ◽  
Jahangir Amin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Mutant P53

Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis

2015 ◽  
Vol 359 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Chantal Bou-Hanna ◽  
Anne Jarry ◽  
Laurence Lode ◽  
Ingo Schmitz ◽  
Klaus Schulze-Osthoff ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Mutant P53 ◽  
Caspase 9 ◽  
Acute Cytotoxicity

scholarly journals Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway

2008 ◽  
Vol 105 (17) ◽  
pp. 6302-6307 ◽  
Author(s):  
J. E. Kravchenko ◽  
G. V. Ilyinskaya ◽  
P. G. Komarov ◽  
L. S. Agapova ◽  
D. V. Kochetkov ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Mutant P53 ◽  
Salvage Pathway
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