Stressful Life Events and Skin Diseases: An Additional Perspective from Research on Psychosomatic Dynamics in Systemic Lupus erythematosus

2002 ◽  
Vol 71 (2) ◽  
pp. 123-124 ◽  
Author(s):  
C. Schubert ◽  
W. Geser ◽  
B. Noisternig ◽  
P. König ◽  
G. Rumpold ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Life Events ◽  
Lupus Erythematosus ◽  
Stressful Life Events ◽  
Skin Diseases ◽  
Stressful Life ◽  
Systemic Lupus

scholarly journals Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2

2017 ◽  
Vol 43 (2) ◽  
pp. 832-839 ◽  
Author(s):  
Qingjun Pan ◽  
Yongmin Feng ◽  
Yanxia Peng ◽  
Hongjiu Zhou ◽  
Zhenzhen Deng ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Migration Rate ◽  
Skin Diseases ◽  
Normal Skin ◽  
Flow Cytometric Analysis ◽  
Skin Lesions ◽  
Skin Tissue ◽  
Systemic Lupus

Background/Aims: Basophils have been reported to infiltrate skin lesions in various skin diseases, but not in systemic lupus erythematosus (SLE). This study investigated basophil infiltration in SLE and its mechanism. Methods: Twenty newly diagnosed SLE patients and twenty healthy controls were enrolled. Nine SLE patients underwent skin biopsies. Flow cytometric analysis the phenotype of peripheral basophils and their migration rate toward RANTES and MCP-1 were analyzed with the transwell culture system, also the expression of these two chemokines in skin tissue were analyzed with immunohistochemistry. Results: Increased activation and decreased numbers of peripheral basophils were observed in SLE patients compared with controls. Basophil migration into skin lesions of SLE patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils. In vitro studies showed that migration rate toward RANTES and MCP-1 increased significantly in basophils from SLE patients compared with those from controls. Consistently, high levels of RANTES and MCP-1 expression were observed in skin lesions from SLE patients but not in normal skin tissue. Conclusion: Basophil recruitment to skin lesions of SLE patients mediated by CCR1 and CCR2, which may contribute to tissue damage in SLE.

scholarly journals 565 Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

2018 ◽  
Vol 138 (5) ◽  
pp. S96
Author(s):  
M. Tarazi ◽  
R.G. Gaffney ◽  
D. Pearson ◽  
C.J. Kushner ◽  
V.P. Werth
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Systemic Lupus

ANTI-DNA ANTIBODIES OF VARIOUS SKIN DISEASES, ESPECIALLY OF SYSTEMIC LUPUS ERYTHEMATOSUS

1979 ◽  
Vol 6 (2) ◽  
pp. 117-123
Author(s):  
Masahiro Idemori ◽  
Hideaki Hanamiya ◽  
Shoko Yasaka ◽  
Shoichiro Kudo ◽  
Tatsuyoshi Arao
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Systemic Lupus ◽  
Dna Antibodies

scholarly journals AB001. Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

2019 ◽  
Vol 7 (S4) ◽  
pp. AB001-AB001
Author(s):  
Meera Tarazi ◽  
Rebecca G. Gaffney ◽  
David Pearson ◽  
Carolyn J. Kushner ◽  
Victoria P. Werth
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Systemic Lupus

scholarly journals Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

2019 ◽  
Vol 180 (6) ◽  
pp. 1468-1472 ◽  
Author(s):  
M. Tarazi ◽  
R.G. Gaffney ◽  
D. Pearson ◽  
C.J. Kushner ◽  
V.P. Werth
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Systemic Lupus

The Effects of Daily Stress and Stressful Life Events on the Clinical Symptomatology of Patients With Lupus Erythematosus

2004 ◽  
Vol 66 (5) ◽  
pp. 788-794 ◽  
Author(s):  
Maria I. Peralta-Ramírez ◽  
Juan Jiménez-Alonso ◽  
Juan F. Godoy-García ◽  
Miguel Pérez-García
Keyword(s):  
Life Events ◽  
Lupus Erythematosus ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Daily Stress ◽  
Clinical Symptomatology
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