High-Grade Endometrial Stromal Sarcoma after Tamoxifen Therapy for Breast Cancer

2005 ◽  
Vol 60 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Francesco Sesti ◽  
Lodovico Patrizi ◽  
Beatrice Ermini ◽  
Giampiero Palmieri ◽  
Augusto Orlandi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endometrial Stromal Sarcoma ◽  
Tamoxifen Therapy ◽  
High Grade ◽  
Stromal Sarcoma

High-grade endometrial stromal sarcoma after treatment with tamoxifen in a patient treated for breast cancer

2003 ◽  
Vol 13 (5) ◽  
pp. 690-692 ◽  
Author(s):  
Y. Saga ◽  
M. Ohwada ◽  
T. Kohno ◽  
N. Takayashiki ◽  
M. Suzuki
Keyword(s):  
Breast Cancer ◽  
Endometrial Stromal Sarcoma ◽  
Tamoxifen Therapy ◽  
Low Grade ◽  
High Grade ◽  
Stromal Sarcoma ◽  
Endometrial Epithelium ◽  
Sarcoma Cells ◽  
Disease Free

Tamoxifen has been widely used in breast cancer treatment. In recent years, the occurrence of uterine malignancies in patients receiving long-term tamoxifen therapy has attracted attention. Most of these malignancies are endometrial adenocarcinomas, but low-grade endometrial stromal sarcomas have occasionally been reported. Here we report a woman who developed a high-grade endometrial stromal sarcoma after receiving postmastectomy tamoxifen therapy. The patient underwent a left mastectomy at age 45 and subsequently received oral tamoxifen for 3 years. At age 51, she was diagnosed with endometrial stromal sarcoma, for which a radical hysterectomy was performed. High-grade endometrial stromal sarcoma was diagnosed by postoperative histologic examination. Immunostaining for the estrogen receptor was negative in sarcoma cells, but positive in the residual endometrial epithelium and the nucleus of adjacent stromal cells within the tumor. The patient has now survived disease-free for 37 months after surgery.

Primary Extra-Uterine Endometrial Stromal Sarcoma and Synchronous Breast Cancer: A Double Whammy: A Case report

2021 ◽  
Author(s):  
Pavneet Kohli ◽  
Prasanth Penumadu ◽  
Neelesh Srivastava ◽  
Bheemanathi Hanuman Srinivas ◽  
Vidyalakshmi Rangarajan
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Endometrial Stromal Sarcoma ◽  
Stromal Sarcoma ◽  
Synchronous Breast Cancer

Low-grade endometrial stromal sarcoma developing in a postmenopausal woman under toremifene treatment for breast cancer

2012 ◽  
Vol 39 (1) ◽  
pp. 424-429 ◽  
Author(s):  
Tomoko Kashiyama ◽  
Katsutoshi Oda ◽  
Kei Kawana ◽  
Takahide Arimoto ◽  
Yukiko Kanetaka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Woman ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Stromal Sarcoma

ESR1 hotspot mutations in endometrial stromal sarcoma with high-grade transformation and endocrine treatment

2021 ◽  
Author(s):  
Kimberly Dessources ◽  
Kathryn M. Miller ◽  
Elizabeth Kertowidjojo ◽  
Arnaud Da Cruz Paula ◽  
Youran Zou ◽  
...  
Keyword(s):  
Endometrial Stromal Sarcoma ◽  
Endocrine Treatment ◽  
High Grade ◽  
Stromal Sarcoma ◽  
Hotspot Mutations ◽  
High Grade Transformation

Aromatase inhibitors of the third generation in endocrine therapy of breast cancer and endometrial cancer: the successes and failures of the combination therapy

2016 ◽  
Vol 14 (2) ◽  
pp. 47-57
Author(s):  
Ekaterina P Fadeeva ◽  
Alla S Lisyanskaya ◽  
Georgiy M Manikhas ◽  
Ruslan I Glushakov ◽  
Natalia I Tapilskaya
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Endometrial Cancer ◽  
Combination Therapy ◽  
Endocrine Therapy ◽  
Endometrial Stromal Sarcoma ◽  
Current Evidence ◽  
Third Generation ◽  
The Third ◽  
Stromal Sarcoma

This review provides the current evidence of clinical studies on the effectiveness of endocrine therapy for breast cancer and endometrial cancer, including endometrial stromal sarcoma, by aromatase inhibitor (AI) III generation. The review presents dates from clinical trials comparing the effectiveness of AI and tamoxifen, as well as dates on combination therapy AI with inhibitors of mTOR pathway (BOLERO-2 trial), an antiestrogen (SWOG S0226, FACT, FIRST trials), an inhibitor of CDK4 / 6 (PALOMA -1 trial) and other drugs.

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