A Meta-Analysis: Comparison of Esomeprazole and Other Proton Pump Inhibitors in Eradicating Helicobacter pylori

Digestion ◽  
2006 ◽  
Vol 73 (2-3) ◽  
pp. 178-186 ◽  
Author(s):  
Xia Wang ◽  
Jing-Yuan Fang ◽  
Rong Lu ◽  
Dan-Feng Sun
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis

Su1681 Meta-Analysis of Studies Comparing the First and New Generation Proton Pump Inhibitors in the Eradication of Helicobacter pylori

2012 ◽  
Vol 142 (5) ◽  
pp. S-481 ◽  
Author(s):  
Adrian G. McNicholl ◽  
Pablo M. Linares ◽  
Olga Perez Nyssen ◽  
Xavier Calvet ◽  
Javier P Gisbert
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
New Generation

The effect of CYP2C19 gene polymorphism on the eradication rate of Helicobacter pylori by proton pump inhibitors-containing regimens in Asian populations: a meta-analysis

2021 ◽  
Vol 22 (13) ◽  
pp. 859-879
Author(s):  
Juan Fu ◽  
Chang-Feng Sun ◽  
Hong-Yan He ◽  
Suvash Chandra Ojha ◽  
Han Shi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gene Polymorphism ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Eradication Rate ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Asian Populations ◽  
Cyp2c19 Polymorphism ◽  
H Pylori

Premise: The effects of proton pump inhibitors (PPI) depend on metabolic enzyme CYP2C19 that has different activity due to gene polymorphism. The purpose of this meta-analysis is to determine the potential effects of CYP2C19 polymorphism on the efficiency of PPI-based treatment. Materials & methods: The PubMed, EMBASE, Cochrane Library, etc. were searched for relevant articles published in English or Chinese from inception to 31 May 2020. Finally, 26 randomized controlled trials and 15 cohort studies met the inclusion criteria and used for the meta-analysis via STATA version 15. Results: Poor metabolizer (PM) genotype Helicobacter pylori eradication rates were highest for Asian individuals receiving triple or quadruple first-line therapy based on PPIs (p < 0.05). CYP2C19 polymorphism could influence H. pylori eradication rate only in Mainland China and Japan (p < 0.05). Conclusion: PM genotype facilitates the elimination of H. pylori in Asian populations. Rabeprazole-, esomeprazole- and pantoprazole-based eradication program was less affected by the CYP2C19 polymorphism.

scholarly journals Effectiveness and Safety of Vonoprazan versus Proton Pump Inhibitors for Second-Line Helicobacter pylori Eradication Therapy: Systematic Review and Meta-Analysis

Digestion ◽  
2020 ◽  
pp. 1-7 ◽  
Author(s):  
Satoshi Shinozaki ◽  
Yasutoshi Kobayashi ◽  
Hiroyuki Osawa ◽  
Hirotsugu Sakamoto ◽  
Yoshikazu Hayashi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
Eradication Therapy ◽  
Second Line
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