scholarly journals Safety and Efficacy of Itraconazole Compared to Amphotericin B as Empirical Antifungal Therapy for Neutropenic Fever in Patients with Haematological Malignancy*

2007 ◽  
Vol 30 (4) ◽  
pp. 185-191 ◽  
Author(s):  
Ulrich Schuler ◽  
Susanne Bammer ◽  
Walter E. Aulitzky ◽  
Claudia Binder ◽  
Angelika Böhme ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Antifungal Therapy ◽  
Haematological Malignancy ◽  
Neutropenic Fever ◽  
Safety And Efficacy ◽  
Empirical Antifungal Therapy

scholarly journals Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
M. Proesmans ◽  
F. Vermeulen ◽  
M. Vreys ◽  
K. De Boeck
Keyword(s):  
Cystic Fibrosis ◽  
Amphotericin B ◽  
Antifungal Therapy ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Lung Infection ◽  
Steroid Withdrawal ◽  
Successful Therapy ◽  
Lipid Complex ◽  
Safety And Efficacy ◽  
Systemic Corticosteroids

Background. Systemic steroids and adjunctive antifungal therapy are the cornerstone in treating allergic bronchopulmonary aspergillosis (ABPA) in the context of CF.Aim. Evaluate the use of inhaled amphotericin B (iAMB) as antifungal agent in this context.Methods. Report of 7 CF patients with recurrent or difficult to treat ABPA and failure to taper systemic corticosteroids treated with AMB deoxycholate (AMB-d) (Fungizone 25 mg 3× a week) or AMB lipid complex (ABLC) (Abelcet 50 mg twice weekly). Successful therapy was defined as steroid withdrawal without ABPA relapse within 12 months.Results. Therapy was successful in 6 of 7 patients treated with iAMB. In 5/6, lung function improved. The patient with treatment failure has concomitant MAC lung infection.Conclusion. Inhaled AMB may be an alternative to commonly used adjunctive antifungal therapy in the treatment of ABPA. More data are needed on safety and efficacy.

Caspofungin versus Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Persistent Fever and Neutropenia

2004 ◽  
Vol 351 (14) ◽  
pp. 1391-1402 ◽  
Author(s):  
Thomas J. Walsh ◽  
Hedy Teppler ◽  
Gerald R. Donowitz ◽  
Johan A. Maertens ◽  
Lindsey R. Baden ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Antifungal Therapy ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Persistent Fever ◽  
Empirical Antifungal Therapy
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