Clinical and Pathological Features of Membranous Glomerulonephritis of Systemic Lupus erythematosus

1984 ◽  
Vol 4 (5) ◽  
pp. 301-311 ◽  
Author(s):  
Melvin M. Schwartz ◽  
Karen Kawala ◽  
Jimmy L. Roberts ◽  
Caroline Humes ◽  
Edmund J. Lewis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Membranous Glomerulonephritis ◽  
Pathological Features ◽  
Systemic Lupus ◽  
Clinical And Pathological Features

Systemic lupus erythematosus with membranous glomerulonephritis and uterine vasculitis

1997 ◽  
Vol 29 (2) ◽  
pp. 277-279 ◽  
Author(s):  
Sandro Feriozzi ◽  
Andrea Onetti Muda ◽  
Mostafa Amini ◽  
Tullio Faraggiana ◽  
Enzo Ancarani
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Membranous Glomerulonephritis ◽  
Systemic Lupus

scholarly journals Systemic Lupus Erythematosus and Pregnancy Outcome in Tertiary Level Hospital of Nepal

2019 ◽  
Vol 2 (1) ◽  
pp. 167-172
Author(s):  
Suniti Rawal ◽  
Pooja Paudyal ◽  
Mahesh Raj Sigdel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Multidisciplinary Approach ◽  
Membranous Glomerulonephritis ◽  
Reproductive Age ◽  
University Teaching ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Systemic Lupus ◽  
Planned Pregnancy

Introduction: Systemic Lupus Erythematosus is an autoimmune disease frequently prevalent in women starting from early childhood and towards the reproductive age. Pregnancy with SLE has always imposed great risk both to the mother and the fetus. A multidisciplinary approach with Nephrologist, neonatologist and senior obstetrician during remission leads to a favorable response, through limitation and complications with the use of drugs impose difficulties in their management.Materials and Methods: A prospective, descriptive study was conducted in the Department of Obstetrics and Gynecology and Nephrology at Tribhuvan University Teaching Hospital, for 2 years, from June 2015 to 2017. The study included obstetrical and related complications with outcome in pregnant patients with Systemic Lupus Erythematosus.Results: A total of 19 cases were analyzed of which 15 (79%) had a viable pregnancy and 4 (21%) abortions. Of thirteen cases, 4 (21%) had antiphospholipid antibody syndrome, 8 (42.1%) lupus, and membranous glomerulonephritis and 1 (5.2%) lupus optic neuropathy with loss of vision. All the patients were under drug therapy, like prednisolone, azathioprine, hydroxychloroquine, aspirin, low molecular weight Heparin, tacrolimus, and cyclophosphamide. Only 2 (10.5%) of 19 developed severe pre-eclampsia. There were 12 (80%) term and 3 (20%) each of preterm and intrauterine growth retardation pregnancies with 1 (6.6%) neonatal death (NND) and 1 (5.2%) maternal mortality.Conclusions: Multidisciplinary approach and planned pregnancy reduces the risk of probable complications in the patient resulting to a decreased morbidity and mortality.

scholarly journals Thrombotic thrombocytopenic purpura and membranous glomerulonephritis: A pregnancy-induced case

2014 ◽  
Vol 1 (2) ◽  
pp. 60
Author(s):  
Edyta Golembiewska ◽  
Grażyna Dutkiewicz ◽  
Joanna Stepniewska ◽  
Katarzyna Bobrek-Lesiakowska ◽  
Jarosław Przybyciński ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Thrombotic Microangiopathy ◽  
Kidney Biopsy ◽  
Membranous Glomerulonephritis ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura ◽  
Serological Data

The association of thrombotic thrombocytopenic purpura and severe proteinuria is uncommon. The majority of such patients had already been diagnosed with systemic lupus erythematosus (SLE) and present overlapping symptoms of these two diseases. We report a case of thrombotic thrombocytopenic purpura (TTP) accompanied by severe proteinuria developed simultaneously during pregnancy. Clinical and serological data for SLE were negative. Kidney biopsy revealed features of chronic thrombotic microangiopathy and membranous glomerulonephritis.

Inflammatory myositis in systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (7) ◽  
pp. 776-781
Author(s):  
Nicole Bitencourt ◽  
E Blair Solow ◽  
Tracey Wright ◽  
Bonnie L Bermas
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Lupus Erythematosus ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Pathological Features ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Inflammatory Myositis ◽  
Black Race

Background The coexistence of inflammatory myositis in systemic lupus erythematosus (SLE) has not been extensively studied. In this study, we describe the incidence, distinct types of inflammatory myositis, and risk factors for this finding in a cohort of pediatric and adult SLE patients. Methods We identified SLE patients with coexisting myositis followed between 2010 and 2019 at two pediatric hospitals and one adult hospital. Demographic, clinical, laboratory, and pathological features of myositis were collected, and descriptive statistics were applied. Results A total of 1718 individuals were identified as having SLE (451 pediatric and 1267 adult patients). Of these, 108 were also diagnosed with inflammatory myositis (6.3%). People of black race had a significantly higher prevalence of inflammatory myositis, as did those with childhood-onset SLE compared to adult-onset disease. In the majority of patients (68%), SLE and inflammatory myositis presented concurrently. Overlapping features of systemic sclerosis occurred in 48%, while dermatomyositis-specific rashes were present in a third. Arthralgias and inflammatory arthritis were seen in >90%. Thrombotic events and significant pregnancy-related morbidity were present in more than a third of patients. Lymphopenia, hypocomplementemia, and a positive RNP were the most common laboratory features noted. Myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA) were present in >40% of patients. A review of 28 muscle biopsy reports revealed a wide array of pathological features, including nonspecific changes, dermatomyositis, polymyositis, and necrotizing auto-immune myopathy. Conclusion In our SLE patient population, 6.3% presented with concurrent inflammatory myositis. Dermatomyositis-specific rashes, clinical features of systemic sclerosis, arthralgias and arthritis, and cytopenias were common coexisting clinical manifestations. A high frequency of RNP, MSA, and MAA were found. People of black race and with childhood-onset disease had a higher prevalence of myositis. Our findings suggest that SLE patients of black race, with childhood-onset SLE, and who possess MSA or MAA should be routinely screened for myositis.

scholarly journals ROLE OF GAMMA GLOBULINS IN PATHOGENESIS OF RENAL LESIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND CHRONIC MEMBRANOUS GLOMERULONEPHRITIS, WITH AN OBSERVATION ON THE LUPUS ERYTHEMATOSUS CELL REACTION

1957 ◽  
Vol 106 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Robert C. Mellors ◽  
Louis G. Ortega ◽  
Halsted R. Holman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Serum Proteins ◽  
Fluorescent Antibody ◽  
Periodic Acid ◽  
Membranous Glomerulonephritis ◽  
Systemic Lupus ◽  
Periodic Acid Schiff ◽  
Renal Lesions ◽  
Γ Globulins

Utilizing the fluorescent antibody method for the histologic demonstration of localized γ-globulins, we have made the following observations (in contradistinction to the lack of such findings in a variety of normal and pathologic, control kidneys). In systemic lupus erythematosus (a) γ-globulins were localized in the thickened capillary walls, the "wire-loop" lesions, and the so called "hyaline thrombi" in glomeruli; (b) these sites of localization of γ-globulins were correlated to a considerable degree with the pattern of accentuated eosinophilia of the glomeruli, as seen in hematoxylin-eosin sections, or with the pattern of PAS-positive areas in the glomeruli in sections stained with the periodic acid-Schiff reaction; (c) and γ-globulins were localized rarely in large cytoplasmic granules in tubular epithelium and occasionally in glomerular capsular crescents, tubular protein casts, and inflammatory cells, particularly in the cytoplasm of cells identified as immature and mature plasma cells. In nephrotic glomerulonephritis (a) γ-globulins were localized in the glomerular basement membrane and appertaining structures in chronic membranous glomerulonephritis; (b) γ-globulins were apparently localized in the altered mesangium in chronic lobular glomerulonephritis; and (c) in the tubular protein casts, presumably representing abnormal glomerular filtrates, γ-globulins were present in a lesser concentration and other serum proteins in a greater concentration than found in the glomeruli. In positive lupus erythematosus preparations the nuclei of leukocytes, while undergoing transformation and subsequent phagocytosis to form lupus erythematosus cells, were the sites of localization of γ-globulin (presumably the lupus erythematosus factor) whereas in control preparations no nuclear localization of γ-globulin occurred. These observations are discussed in relation to the pathogenesis of renal lesions in systemic lupus erythematosus, chronic membranous glomerulonephritis, and amyloidosis.

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