scholarly journals ROLE OF GAMMA GLOBULINS IN PATHOGENESIS OF RENAL LESIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND CHRONIC MEMBRANOUS GLOMERULONEPHRITIS, WITH AN OBSERVATION ON THE LUPUS ERYTHEMATOSUS CELL REACTION

1957 ◽  
Vol 106 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Robert C. Mellors ◽  
Louis G. Ortega ◽  
Halsted R. Holman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Serum Proteins ◽  
Fluorescent Antibody ◽  
Periodic Acid ◽  
Membranous Glomerulonephritis ◽  
Systemic Lupus ◽  
Periodic Acid Schiff ◽  
Renal Lesions ◽  
Γ Globulins

Utilizing the fluorescent antibody method for the histologic demonstration of localized γ-globulins, we have made the following observations (in contradistinction to the lack of such findings in a variety of normal and pathologic, control kidneys). In systemic lupus erythematosus (a) γ-globulins were localized in the thickened capillary walls, the "wire-loop" lesions, and the so called "hyaline thrombi" in glomeruli; (b) these sites of localization of γ-globulins were correlated to a considerable degree with the pattern of accentuated eosinophilia of the glomeruli, as seen in hematoxylin-eosin sections, or with the pattern of PAS-positive areas in the glomeruli in sections stained with the periodic acid-Schiff reaction; (c) and γ-globulins were localized rarely in large cytoplasmic granules in tubular epithelium and occasionally in glomerular capsular crescents, tubular protein casts, and inflammatory cells, particularly in the cytoplasm of cells identified as immature and mature plasma cells. In nephrotic glomerulonephritis (a) γ-globulins were localized in the glomerular basement membrane and appertaining structures in chronic membranous glomerulonephritis; (b) γ-globulins were apparently localized in the altered mesangium in chronic lobular glomerulonephritis; and (c) in the tubular protein casts, presumably representing abnormal glomerular filtrates, γ-globulins were present in a lesser concentration and other serum proteins in a greater concentration than found in the glomeruli. In positive lupus erythematosus preparations the nuclei of leukocytes, while undergoing transformation and subsequent phagocytosis to form lupus erythematosus cells, were the sites of localization of γ-globulin (presumably the lupus erythematosus factor) whereas in control preparations no nuclear localization of γ-globulin occurred. These observations are discussed in relation to the pathogenesis of renal lesions in systemic lupus erythematosus, chronic membranous glomerulonephritis, and amyloidosis.

scholarly journals An Extract ofAntrodia camphorataMycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Jia-Ming Chang ◽  
Yi-Ru Lee ◽  
Le-Mei Hung ◽  
Sheng-Yung Liu ◽  
Mao-Tien Kuo ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Lupus Erythematosus ◽  
Interleukin 1 ◽  
Periodic Acid ◽  
Folk Medicine ◽  
Systemic Lupus ◽  
Urine Protein ◽  
Periodic Acid Schiff

Antrodia camphoratais used in folk medicine for the treatment of inflammation syndromes and liver-related diseases in Taiwan. The goal of this study was to evaluate the efficacy of the mycelial extract ofA. camphorata(ACE) for the treatment of systemic lupus erythematosus (SLE) in SLE-prone NZB/W F1 mice. After antibodies against double-stranded DNA appeared in NZB/W mice, the mice were orally administered varying dosages of ACE (100, 200 and 400 mg kg−1) for 5 consecutive days per week for 12 weeks via gavage. To assess the efficacy of ACE, we measured SLE-associated biochemical and histopathological biomarkers levels of blood urine nitrogen (BUN), blood creatinine, urine protein and urine creatinine and thickness of the kidney glomerular basement membrane by staining with periodic acid-Schiff. Antroquinonol, an active component of ACE, was investigated for anti-inflammation activity in lipopolysaccharide-induced RAW 267.4 cells. ACE at 400 mg kg−1significantly suppressed urine protein and serum BUN levels and decreased the thickness of the kidney glomerular basement membrane. Antroquinonol significantly inhibited the production of tumor necrosis factor-αand interleukin-1βby 75 and 78%, respectively. In conclusion, ACE reduced urine protein and creatinine levels and suppressed the thickening of the kidney glomerular basement membrane, suggesting that ACE protects the kidney from immunological damage resulting from autoimmune disease.

scholarly journals Canine Systemic Lupus Erythematosus

Blood ◽  
1965 ◽  
Vol 25 (2) ◽  
pp. 143-160 ◽  
Author(s):  
ROBERT M. LEWIS ◽  
ROBERT SCHWARTZ ◽  
WILLIAM B. HENRY
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Autoimmune Hemolytic Anemia ◽  
Serum Proteins ◽  
Antithyroid Antibody ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura ◽  
Renal Lesions ◽  
Naturally Occurring ◽  
Immunologic Disease

Abstract A naturally occurring immunologic disease, characterized by autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura and nephritis, is described in seven dogs. The disease primarily affected formed elements in the blood, glomeruli and blood vessels. Abnormal serum proteins, including the LE factor, rheumatoid factor and antithyroid antibody were found in affected dogs. Corticosteroids and splenectomy were effective in controlling the hematologic components of the disease, but apparently had no effect on the renal lesions. Recurrence was frequent and the prognosis was grave. Additional abnormalities, including malar eruption, intermittent lameness and alopecia were occasionally found as an integral part in the sequential involvement of several tissues during the course of the disease.

Systemic lupus erythematosus with membranous glomerulonephritis and uterine vasculitis

1997 ◽  
Vol 29 (2) ◽  
pp. 277-279 ◽  
Author(s):  
Sandro Feriozzi ◽  
Andrea Onetti Muda ◽  
Mostafa Amini ◽  
Tullio Faraggiana ◽  
Enzo Ancarani
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Membranous Glomerulonephritis ◽  
Systemic Lupus

scholarly journals Serum Proteins in Systemic Lupus Erythematosus

BMJ ◽  
1959 ◽  
Vol 2 (5155) ◽  
pp. 795-798 ◽  
Author(s):  
E. G. Rees ◽  
M. Wilkinson
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Serum Proteins ◽  
Systemic Lupus

SYSTEMIC LUPUS ERYTHEMATOSUS AND SYNDROMES POSSIBLY RELATED

PEDIATRICS ◽  
1957 ◽  
Vol 19 (6) ◽  
pp. 1109-1123
Author(s):  
M. A. Ogryzlo ◽  
H. A. Smythe
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Serum Proteins ◽  
Clinical Manifestations ◽  
Electrophoretic Pattern ◽  
Chemotherapeutic Agents ◽  
Systemic Lupus ◽  
Relationship Of ◽  
The Relationship

Attention is drawn to the difficulties that may be encountered in the positive identification and classification of many patients suspected of suffering from systemic lupus erythematosus. Much of this is due to a lack of specific criteria, either clinical or pathologic, for the diagnosis of the disease. The problem has been made more difficult by the recognition of a number of other syndromes that bear a superficial resemblance to systemic lupus erythematosus, yet differ in clinical manifestations, natural course, prognosis and other respects. A feature common to the group is the presence of the L.E. cell phenomenon. The related conditions differ from lupus enythematosus in that the L.E. phenomenon may only be demonstrable intermittently especially during severe exacerbations of the disease, while at the same time disturbances in the electrophoretic pattern of the serum proteins may be much more profound. In systemic rheumatoid disease the prognosis without steroid therapy is better than in systemic lupus erythematosus, although the morbidity may be great. The reactions which follow administration of certain chemotherapeutic agents are of considerable interest, particularly in view of the similarity to lupus erythematosus and rheumatoid arthritis, and the reversibility on withdrawal of the offending agent. The relationship of these syndromes to each other and to classical systemic lupus erythematosus has not yet been resolved, and inclusion of them under the diagnosis of systemic lupus erythematosus at this time must be regarded as premature.

scholarly journals THE PRECIPITIN REACTION BETWEEN DNA AND A SERUM FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS

1959 ◽  
Vol 109 (1) ◽  
pp. 97-114 ◽  
Author(s):  
H. R. G. Deicher ◽  
H. R. Holman ◽  
H. G. Kunkel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Double Diffusion ◽  
Serum Factor ◽  
Systemic Lupus ◽  
Related Factors ◽  
Antigenic Properties ◽  
Γ Globulins ◽  
Specific Reactions ◽  
Precipitating Factor

The sera of certain patients with systemic lupus erythematosus contain an antibody-like substance capable of reacting with highly purified DNA preparations from widely divergent sources. Precipitin reactions have been demonstrated by double diffusion in agar and quantitative precipitin curves have been obtained. Complement was observed to be fixed in the reaction. Evidence was obtained that the serum factor possessed antigenic properties similar to those of γ-globulins and migrated with this fraction on zone electrophoresis. The interaction of this factor with DNA exhibited certain specific characteristics which differ considerably from non-specific reactions between DNA and proteins in general. The DNA-precipitating factor appeared to be one of a number of related factors reacting with nuclear constituents of many different cells. It differed in certain respects from the "LE factor" which is responsible for the formation of "LE cells." The accumulated evidence, although not yet conclusive, favors the concept that the precipitating factor represents an antibody to DNA, and that it is one of a number of autoantibodies elicited in this disease.

scholarly journals Systemic Lupus Erythematosus and Pregnancy Outcome in Tertiary Level Hospital of Nepal

2019 ◽  
Vol 2 (1) ◽  
pp. 167-172
Author(s):  
Suniti Rawal ◽  
Pooja Paudyal ◽  
Mahesh Raj Sigdel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Multidisciplinary Approach ◽  
Membranous Glomerulonephritis ◽  
Reproductive Age ◽  
University Teaching ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Systemic Lupus ◽  
Planned Pregnancy

Introduction: Systemic Lupus Erythematosus is an autoimmune disease frequently prevalent in women starting from early childhood and towards the reproductive age. Pregnancy with SLE has always imposed great risk both to the mother and the fetus. A multidisciplinary approach with Nephrologist, neonatologist and senior obstetrician during remission leads to a favorable response, through limitation and complications with the use of drugs impose difficulties in their management.Materials and Methods: A prospective, descriptive study was conducted in the Department of Obstetrics and Gynecology and Nephrology at Tribhuvan University Teaching Hospital, for 2 years, from June 2015 to 2017. The study included obstetrical and related complications with outcome in pregnant patients with Systemic Lupus Erythematosus.Results: A total of 19 cases were analyzed of which 15 (79%) had a viable pregnancy and 4 (21%) abortions. Of thirteen cases, 4 (21%) had antiphospholipid antibody syndrome, 8 (42.1%) lupus, and membranous glomerulonephritis and 1 (5.2%) lupus optic neuropathy with loss of vision. All the patients were under drug therapy, like prednisolone, azathioprine, hydroxychloroquine, aspirin, low molecular weight Heparin, tacrolimus, and cyclophosphamide. Only 2 (10.5%) of 19 developed severe pre-eclampsia. There were 12 (80%) term and 3 (20%) each of preterm and intrauterine growth retardation pregnancies with 1 (6.6%) neonatal death (NND) and 1 (5.2%) maternal mortality.Conclusions: Multidisciplinary approach and planned pregnancy reduces the risk of probable complications in the patient resulting to a decreased morbidity and mortality.

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