Effect of Growth Hormone-Releasing Factor on Plasma Growth Hormone, Prolactin and Somatomedin C in Hypopituitary and Short Normal Children

Abstract. Synthetic human pancreatic GRF (hpGRF-44) was administered sc to 8 normal children with short stature and 11 patients with GH deficiency. After a dose of 100–200 μg hpGRF-44, mean plasma GH levels reached a peak at 15 min of 27.2 ± 6.4 (± se) ng/ml in normal children. However the responses were variable and peak plasma GH varied from 10.1 to 56.5 ng/ml. Eight of 11 patients with idiopathic GH deficiency did not respond to sc administration of 100–300 μg hpGRF-44. However, a plasma GH increase of more than 5 ng/ml occurred in 2 patients and to twice the basal level in 1 patient. Their GH values were 14.3, 5.2 and 3.4 ng/ml, respectively. After repetitive administration of hpGRF-44 (200 μg, twice a day) sc for 5 consecutive days, 2 of 8 patients restored their responsiveness, but the remaining patients did not show GH rise in response to both sc and iv bolus administration of hpGRF-44. Repetitive hpGRF-44 administrations for 5 days had no effect on somatomedin-C production.

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AGE-RELATED CHANGES IN PLASMA GROWTH HORMONE RESPONSE TO GROWTH HORMONE-RELEASING FACTOR IN MAN

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-58-1-212 ◽

1984 ◽

Vol 58 (1) ◽

pp. 212-214 ◽

Cited By ~ 143

Author(s):

Tamotsu Shibasaki ◽

Kazuo Shizume ◽

Mari Nakahara ◽

Akitsugu Masuda ◽

Kazuko Jibiki ◽

...

Keyword(s):

Growth Hormone ◽

Growth Hormone Response ◽

Hormone Response ◽

Plasma Growth Hormone ◽

Growth Hormone Releasing Factor ◽

Age Related ◽

Age Related Changes

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Imitation of normal plasma growth hormone profile by subcutaneous administration of human growth hormone to growth hormone deficient children

Acta Endocrinologica ◽

10.1530/acta.0.1020006 ◽

1983 ◽

Vol 102 (1) ◽

pp. 6-10 ◽

Cited By ~ 44

Author(s):

J. Sandahl Christiansen ◽

H. Ørskov ◽

C. Binder ◽

K. W. Kastrup

Keyword(s):

Growth Hormone ◽

Time Course ◽

Subcutaneous Administration ◽

Molecular Size ◽

Hormone Deficiency ◽

Gel Chromatography ◽

Plasma Growth Hormone ◽

Normal Children ◽

Blood Samples ◽

Long Term Treatment

Abstract. The time course of plasma growth hormone (hGH) levels following sc and im injection of hGH was studied in 12 children with growth hormone deficiency who had received long-term treatment with im injections of highly purified hGH. Also the spontaneous diurnal GH levels in 8 normal children of comparable age were recorded. Blood samples were obtained during 24 h after im and sc injections of 4 IU/m2 hGH and analysed for immunoreactive hGH. While a median peak value of 160 ng/ml (range 135 to 475 ng/ml) was obtained 2 h after im injection, sc injection resulted in a more sustained elevation reaching 41 ng/ml (range 32 to 51 ng/ml) at 6 h subsiding slowly with a median concentration of 15 ng/ml (range 5–24 ng/ml) persisting after 14 h. Gel chromatography demonstrated that the hGH immunoreactivity of blood samples obtained as late as 14 h after sc injection had unaltered molecular size. Seven of the patients were further studied after sc injection of 2 IU/m2 at 20.00 h instead of in the morning. A plasma profile was attained during the night which roughly approximated the average nocturnal plasma pattern of the normal children.

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