Warfarin-Induced Skin Necrosis in 2 Patients with Protein S Deficiency: Successful Reinstatement of Warfarin Therapy

1992 ◽  
Vol 22 (3) ◽  
pp. 124-128 ◽  
Author(s):  
David R. Anderson ◽  
Patrick Brill-Edwards ◽  
Irwin Walker
Keyword(s):  
Skin Necrosis ◽  
Warfarin Therapy ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency

scholarly journals Sepsis as a cause of acquired Protein C and Protein S deficiency- A case report and literature review

2014 ◽  
Vol 52 (193) ◽  
pp. 729-731
Author(s):  
Arun Kannan ◽  
Jose Lizcano ◽  
Sweta Chandra ◽  
Christie Murphy
Keyword(s):  
Septic Shock ◽  
Skin Necrosis ◽  
Protein C ◽  
Warfarin Therapy ◽  
Protein S ◽  
Protein S Deficiency ◽  
Protein C Deficiency ◽  
Goal Directed Therapy ◽  
S Deficiency ◽  
Anti Phospholipid Syndrome

Warfarin Induced Skin Necrosis is a well-known complication in patients being started on warfarin without adequate bridging . The mechanism is thought to be due to protein C deficiency . We present a rather unusual cause of protein C deficiency due to sepsis resulting in warfarin induced skin necrosis. 43 year old lady who has been on chronic warfarin therapy secondary to anti phospholipid syndrome was admitted to the hospital for acute ischemic cerebellar stroke. Warfarin was held due to acute thrombocytopenia. She was discharged after restarting the warfarin. She presented back with septic shock due to pneumonia. She was found to have multiple necrotic areas consistent with skin necrosis. Unfortunately, patient died due to multi organ failure despite goal directed therapy. This case demonstrates the importance of recognizing the sepsis as an acquired cause of protein C deficiency.

scholarly journals Coumarin-induced skin necrosis associated with acquired protein s deficiency and antiphospholipid antibody syndrome

1994 ◽  
Vol 37 (7) ◽  
pp. 1096-1100 ◽  
Author(s):  
Marie-José Wattiaux ◽  
Robert Hervé ◽  
Annie Robert ◽  
Jean Cabane ◽  
Bruno Housset ◽  
...  
Keyword(s):  
Skin Necrosis ◽  
Protein S ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Protein S Deficiency ◽  
S Deficiency

scholarly journals Warfarin-induced skin necrosis: a rare condition

2020 ◽  
Vol 54 (4) ◽  
pp. 269-273
Author(s):  
Josephine Nsaful ◽  
Yaw Ofori Adjei ◽  
Florence Dedey ◽  
Nelson Agboadoh ◽  
Edem Anyigba ◽  
...  
Keyword(s):  
Renal Failure ◽  
Skin Necrosis ◽  
Rare Condition ◽  
Skin Grafting ◽  
Protein S ◽  
Protein S Deficiency ◽  
Wound Debridement ◽  
S Deficiency ◽  
Life Threatening ◽  
Life Threatening Complication

Warfarin induced skin necrosis is a rare debilitating and, in some cases, life-threatening complication. A 47-year-old male on life-long anticoagulation omits his medication and develops extensive skin necrosis of the left leg complicated by acute renal failure three days after restarting warfarin. Investigations reveal possible Protein S deficiency which is known to be a predisposing condition. Various mechanisms have been proposed as the underlying cause. He was managed on heparin, wound debridement and skin grafting. Warfarin was restarted concurrently with heparin. Knowledge of this complication will enable timely diagnosis and treatment.

scholarly journals Warfarin-induced skin necrosis in a patient with protein S deficiency

2018 ◽  
Vol 93 (4) ◽  
pp. 612-613 ◽  
Author(s):  
Ruana Fraga ◽  
Lucia Martins Diniz ◽  
Elton Almeida Lucas ◽  
Paulo Sergio Emerich
Keyword(s):  
Skin Necrosis ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency
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