scholarly journals Estimating Sibling Recurrence Risk in Population Sample Surveys

2013 ◽  
Vol 76 (1) ◽  
pp. 18-27 ◽  
Author(s):  
Barry I. Graubard ◽  
Monroe G. Sirken
Keyword(s):  
Population Sample ◽  
Recurrence Risk ◽  
Sample Surveys ◽  
Sibling Recurrence Risk

Sibling Recurrence Risk in Autoimmune Thyroid Disease

Thyroid ◽  
2003 ◽  
Vol 13 (8) ◽  
pp. 761-764 ◽  
Author(s):  
R. Villanueva ◽  
D.A. Greenberg ◽  
T.F. Davies ◽  
Y. Tomer
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Recurrence Risk ◽  
Autoimmune Thyroid ◽  
Sibling Recurrence Risk

Sibling recurrence risk in Dupuytren’s disease

2012 ◽  
Vol 38 (4) ◽  
pp. 424-429 ◽  
Author(s):  
R. Capstick ◽  
T. Bragg ◽  
H. Giele ◽  
D. Furniss
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Recurrence Risk ◽  
Dupuytren’S Disease ◽  
Control Groups ◽  
Dupuytren's Disease ◽  
Baseline Characteristics ◽  
Genetic And Environmental Factors ◽  
Sibling Recurrence Risk ◽  
And Control

Dupuytren’s disease is a complex condition, with both genetic and environmental factors contributing to its aetiology. We aimed to quantify the extent to which genetic factors predispose to the disease, through the calculation of sibling recurrence risk (ls), and to calculate the proportion of heritability accounted for by currently known genetic loci. From 174 siblings of patients with surgically confirmed disease, 100 were randomly selected. Controls were recruited from patients attending an ophthalmology outpatient clinic for eye conditions unrelated to diabetes. There were no statistically significant differences in baseline characteristics between the case and control groups. In siblings, 47% had Dupuytren’s disease, compared with 10% of controls, giving a ls of 4.5. Currently known loci that predispose to Dupuytren’s disease account for 12.1% of the total heritability of the disease. Dupuytren’s disease was significantly more common in siblings than in controls. These results accurately quantify the magnitude of the genetic predisposition to Dupuytren’s disease.

Population-Based Estimate of the Sibling Recurrence Risk Ratio for Rhegmatogenous Retinal Detachment

2011 ◽  
Vol 52 (5) ◽  
pp. 2551 ◽  
Author(s):  
Danny Mitry ◽  
Linda Williams ◽  
David G. Charteris ◽  
Brian W. Fleck ◽  
Alan F. Wright ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Risk Ratio ◽  
Rhegmatogenous Retinal Detachment ◽  
Recurrence Risk ◽  
Population Based ◽  
Recurrence Risk Ratio ◽  
Sibling Recurrence Risk
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