Treatment Strategies of Intermediate-Stage Hepatocellular Carcinomas in Japan (Barcelona Clinic Liver Cancer Stage B)

Oncology ◽  
2014 ◽  
Vol 87 (s1) ◽  
pp. 78-81 ◽  
Author(s):  
Koichiro Yamakado ◽  
Masatoshi Kudo
Keyword(s):  
Liver Cancer ◽  
Treatment Strategies ◽  
Intermediate Stage ◽  
Barcelona Clinic Liver Cancer ◽  
Cancer Stage ◽  
Hepatocellular Carcinomas

scholarly journals Unresectable hepatocellular carcinoma treatment with doxorubicin-eluting polyethylene glycol microspheres: a single-center experience

2021 ◽  
pp. HEP38
Author(s):  
Gerardo Tovar-Felice ◽  
Andrés García-Gámez ◽  
Virgilio Benito-Santamaría ◽  
David Balaguer-Paniagua ◽  
Jordi Villalba-Auñón ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Tumor Response ◽  
Intermediate Stage ◽  
Complete Response ◽  
Barcelona Clinic Liver Cancer ◽  
Cancer Stage ◽  
Single Center Experience ◽  
Unresectable Hepatocellular Carcinoma ◽  
Small Cohort

Background: Transarterial chemoembolization (TACE) is indicated for unresectable hepatocellular carcinoma. Methods: This was a retrospective study of 50 hepatocellular carcinoma patients treated with TACE using doxorubicin-loaded LifePearl™ to investigate the safety and efficacy of TACE. Results: There was no 30-day mortality, and limited adverse events were reported. At best tumor response, complete response and disease control were 58% and 94%, respectively, with a median of 4.5 months of follow-up. Median overall survival was 33.8 months. Patients with Barcelona Clinic Liver Cancer stage 0 and stage A at best tumor response showed a higher complete response rate (83%) than patients with Barcelona Clinic Liver Cancer stage B (complete response: 50%; p = 0.0414). Conclusion: Doxorubicin-loaded LifePearl™ TACE might be an effective treatment, with a good safety profile, for patients with early/intermediate-stage hepatocellular carcinoma. Further prospective data, especially with a small cohort of selected patients, are required to confirm these results.

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