Effects of Thromboxane Synthetase Inhibition by UK 38.485 on Ischemic Myocardium during Short-Term Coronary Artery Occlusion*

2015 ◽  
pp. 228-234
Author(s):  
H. Korb ◽  
A. Hoeft ◽  
W. Wober ◽  
H. G. Wolpers ◽  
G. Hellige
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Ischemic Myocardium ◽  
Short Term ◽  
Thromboxane Synthetase ◽  
Uk 38.485

Release of endothelin from the porcine heart after short term coronary artery occlusion

1993 ◽  
Vol 27 (8) ◽  
pp. 1482-1485 ◽  
Author(s):  
T. Tonnessen ◽  
P. A Naess ◽  
K. A Kirkeboen ◽  
J. Offstad ◽  
A. Ilebekk ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Short Term ◽  
Porcine Heart

Improved performance of ischemic canine myocardium in response to nifedipine and diltiazem

1980 ◽  
Vol 239 (5) ◽  
pp. H658-H663 ◽  
Author(s):  
J. E. Perez ◽  
B. E. Sobel ◽  
P. D. Henry
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Occlusion ◽  
Aortic Pressure ◽  
Artery Occlusion ◽  
Ischemic Myocardium ◽  
Control Value ◽  
Anesthetized Dogs ◽  
Improved Performance ◽  
Mean Aortic Pressure ◽  
Canine Myocardium

To characterize the effects of Ca2+ antagonists on the performance of the ischemic myocardium, we administered nifedipine and diltiazem to chloralose-anesthetized dogs with coronary artery occlusion and monitored segmental myocardial shortening in ischemic and nonischemic zones with implanted ultrasonic length gauges. Other dogs were treated with nitroglycerin or nitroprusside for comparison. Dosage of all drugs was adjusted to reduce mean aortic pressure by no more than 5 mmHg. Segmental shortening was expressed as percent of control value before occlusion. In control dogs (n = 8), shortening in ischemic zones 20 and 80 min after occlusion averaged -16 +/- 2% and -17 +/- 2%, indicating paradoxical elongation. With nifedipine (1 +/- 0.4 microgram . kg-1 . h-1; n = 8), shortening of ischemic segments before treatment did not differ from controls, but after 60 min of treatment was markedly improved, averaging 31 +/- 4% (P < 0.05). Diltiazem (10 +/- 2 microgram . kg-1 . h-1; n = 8) produced a similar improvement in shortening in ischemic zones. However, nitroglycerin (177 +/- 20 microgram . kg-1 . h-1; n = 8) and nitroprusside (43 +/- 10 microgram . kg-1 . h-1; n = 8) failed to improve shortening in ischemic regions. Thus, Ca2+ antagonists improved performance in ischemic zones, but nitroglycerin and nitroprusside did not.

Protective effects of hypothermia on ischemic stressed myocardium during short-term, repeated coronary artery occlusion

1982 ◽  
Vol 394 (S1) ◽  
pp. R14-R14
Author(s):  
H. Korb ◽  
A. Hoeft ◽  
D. Baller ◽  
R. Schräder ◽  
H. G. Wolpers ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Protective Effects ◽  
Short Term
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