Diabetic Macular Edema: Natural History and Treatment

2015 ◽  
pp. 213-220
Author(s):  
F. Cardillo Piccolino
Keyword(s):  
Natural History ◽  
Macular Edema ◽  
Diabetic Macular Edema

scholarly journals Natural history of diabetic macular edema and factors predicting outcomes in sham-treated patients (MEAD study)

2019 ◽  
Vol 257 (12) ◽  
pp. 2639-2653
Author(s):  
Young Hee Yoon ◽  
◽  
David S. Boyer ◽  
Raj K. Maturi ◽  
Francesco Bandello ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Natural History ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Older Age ◽  
Antihypertensive Medications ◽  
Good Glycemic Control ◽  
History Of

Abstract Purpose To describe the natural history of diabetic macular edema (DME) with respect to best-corrected visual acuity (BCVA) and central retinal thickness (CRT) outcomes and to identify baseline patient characteristics and systemic factors associated with improvement or worsening of outcomes in sham-treated patients. Methods The study population was sham-treated patients (n = 350) in the 3-year MEAD registration study of dexamethasone intravitreal implant for treatment of DME. Patients had center-involved DME and received sham intravitreal injections in the study eye at ≥ 6-month intervals. Potential prognostic factors for outcomes were evaluated using multiple linear regression analysis. Results Visual and anatomic outcomes were poorer in patients who left the study early (n = 198) than in study completers (n = 152). Mean change in BCVA from baseline at the last visit with available data was + 0.9 letters; 37.5% of patients had no change in BCVA, 23.2% had gained > 10 letters, and 16.0% had lost > 10 letters. Older age and baseline diabetic retinopathy score > 6 were associated with worse BCVA outcomes; thicker baseline CRT and larger number of hypertension medications used were associated with larger reductions in CRT during the study. Conclusions BCVA and CRT outcomes were variable in this population of DME patients with generally good glycemic control. In DME patients without active treatment, older age and baseline diabetic retinopathy score > 6 were associated with less improvement in BCVA; thicker baseline CRT and a larger number of antihypertensive medications used predicted better improvement in CRT. Trial registration The MEAD study trials are registered at ClinicalTrials.gov with the identifiers NCT00168337 and NCT00168389.

Association between the Short-term Natural History of Diabetic Macular Edema and the Vitreomacular Relationship in Type II Diabetes Mellitus

Ophthalmology ◽  
1997 ◽  
Vol 104 (3) ◽  
pp. 473-478 ◽  
Author(s):  
Taiichi Hikichi ◽  
Naoki Fujio ◽  
Jun Akiba ◽  
Yoshinao Azuma ◽  
Masatoshi Takahashi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Natural History ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Short Term ◽  
History Of

Natural History and Predictors of Vision Loss in Eyes with Diabetic Macular Edema and Good Initial Visual Acuity

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Daniella Lent-Schochet ◽  
Therlinder Lo ◽  
Kieu-Yen Luu ◽  
Steven Tran. ◽  
Machelle D. Wilson ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Natural History ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Vision Loss ◽  
Initial Visual Acuity
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