Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients

Background: The etiology of idiopathic granulomatous mastitis (IGM) is unknown, and it is commonly misdiagnosed clinically and/or radiologically as breast cancer. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is still a matter of debate. The aim of the current study is to assess the value of FNAC in the diagnosis of IGM, and to search for the presence of bacteria in IGM with cystic vacuoles, which was described recently by a few authors. Materials and Methods: Retrospective study of cytologic smears and histologic tissue sections of 65 Egyptian IGM cases was done along with microbiologic testing. A comparison of the frequency of IGM in Egypt to that of other populations was also made. Results: IGM has typical FNA features which can easily exclude malignancy. Histologically, cystic vacuoles were encountered in 35 out of 65 cases (53.9%), with only 6 (17.14%) of these cases showing Gram-positive bacilli (GPB). The frequency of IGM in Egypt is comparable to those in other Middle Eastern countries but much higher than in Western countries. Conclusion: IGM is a common breast disease in Egypt. FNAC in IGM has a high diagnostic accuracy. This study supports the few recent studies that have detected GPB in IGM with cystic vacuoles. Thus, bacteriologic examination in such cases may affect the treatment strategy.

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The Role of FNAC in Diagnosis of Breast Disease at Different Ages - 208 Cases

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v30i3.12462 ◽

2012 ◽

Vol 30 (3) ◽

pp. 137-140 ◽

Cited By ~ 1

Author(s):

S M Shafiul Azam Chaudhury ◽

Md Khurshid Alam ◽

Md Serajul Haque

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Breast Disease ◽

Needle Aspiration ◽

Common Disease ◽

Aspiration Cytology ◽

Fine Needle ◽

Different Ages ◽

Needle Aspiration Cytology

All breast lesions are not malignant, and all the benign lesions do not progress to cancer; however the accuracy of diagnosis can be increased by a combination of preoperative tests. About 30% of women suffer from breast disease in their lifetime. The main objectives are to explore the role of FNAC in diagnosis of breast disease at different ages. Fine needle aspiration cytology (FNAC) has become a critical component in the investigation of palpable breast masses. Total 208 cases included in this study at Comilla. The data was formulated and analyzed by SPSS-12. 79(37.98%) cases were at the age of 21-30 years and next one was 11-20 years which was 48(23.07%). Among them 40(19.23%) cases were malignant and 168(80.77%) cases were benign in nature. The incidence of malignancy was increased with relation to age. As the age is more chance of malignancy is more. In benign types fibroadenoma was the common disease then the duct cell carcinoma, fibrocystic change, suppurative inflammation respectively. The findings were 43.75%, 19.23%, 18.27% and 8.65%.In conclusion, fine needle aspiration cytology, for diagnosis of breast lump can reduce the number of open biopsy and surgery. DOI: http://dx.doi.org/10.3329/jbcps.v30i3.12462 J Bangladesh Coll Phys Surg 2012; 30: 137-140

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Idiopathic granulomatous mastitis with erythema nodosum and polyarthritis

Reumatismo ◽

10.4081/reumatismo.2016.844 ◽

2016 ◽

Vol 68 (2) ◽

pp. 97 ◽

Cited By ~ 2

Author(s):

J. Alungal ◽

M.C. Abdulla ◽

R. Narayan

Keyword(s):

Erythema Nodosum ◽

Oral Prednisolone ◽

Needle Aspiration ◽

Left Breast ◽

Chronic Inflammatory Disease ◽

Granulomatous Mastitis ◽

Aspiration Cytology ◽

Idiopathic Granulomatous Mastitis ◽

Painful Mass ◽

Needle Aspiration Cytology

A 25 year-old woman presented with a painful mass in the left breast, polyarthritis and erythema nodosum. Fine needle aspiration cytology led to a diagnosis of granulomatous mastitis. Oral prednisolone rapidly improved the arthritis and the erythema nodosum. Granulomatous mastitis is a very rare, chronic inflammatory disease and only ten patients with granulomatous mastitis with erythema nodosum and polyarthitis have been described.

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Idiopathic granulomatous mastitis-utility of fine needle aspiration cytology (FNAC) in preventing unnecessary surgery

Journal of the Turkish-German Gynecological Association ◽

10.5152/jtgga.2010.18 ◽

2010 ◽

Vol 11 (3) ◽

pp. 127-130 ◽

Cited By ~ 2

Author(s):

Mimi Gangopadhyay ◽

Anuradha De ◽

Indranil Chakrabarti ◽

Sailesh Ray ◽

Amita Giri ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Granulomatous Mastitis ◽

Aspiration Cytology ◽

Idiopathic Granulomatous Mastitis ◽

Fine Needle ◽

Needle Aspiration Cytology

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Granulomatous mastitis-a challenging surgical entity

International Surgery Journal ◽

10.18203/2349-2902.isj20172052 ◽

2017 ◽

Vol 4 (6) ◽

pp. 2077 ◽

Cited By ~ 1

Author(s):

Thrishuli P. B. ◽

Akshata Kamath B.

Keyword(s):

Breast Disease ◽

Needle Aspiration ◽

Chronic Inflammatory Disease ◽

Wide Excision ◽

Reproductive Age ◽

Excision Biopsy ◽

Granulomatous Mastitis ◽

Idiopathic Granulomatous Mastitis ◽

Short Course ◽

Needle Aspiration Cytology

Background: Idiopathic granulomatous mastitis is a rare benign breast disease, first described by Kessler and Wolloch in 1972. It is characterized by chronic necrotizing granulomatous lobulitis of unknown aetiology. The objective of the study is to find out the clinical and management profile of granulomatous mastitis (GM). This study was carried out at JSS hospital, Mysore, Karnataka, India during the period 2014-2016.Methods: Histopathologically diagnosed cases of GM were studied. Data included, detailed history, examination, clinical diagnosis, ultrasound, mammogram and fine needle aspiration cytology (FNAC). All patients were followed for a period of 6 months. Recurrent cases were managed by wide excision and followed for another period of 6 months.Results: 8 patients who were hisptopathologically diagnosed to have granulomatous mastitis were studied. The mean age was found to be 43.5 years. All patients presented with a painless breast lump and were unilateral. The incidence of the same was found to be higher (3.7%) compared to other large volume studies. The best treatment modality with least recurrence in 4 cases was wide local excision and 1 case of quandrantectomy.Conclusions: GM is an uncommon chronic inflammatory disease of the breast. Usually involving a single non-lactating breast in reproductive age group. It clinically mimics tuberculosis and carcinoma. Mammography remains non-conclusive. Excision and wide excision biopsy are both diagnostic and therapeutic in majority of cases. Treatment includes short course of steroids and antibiotic along with close regular surveillance.

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