Spontaneous Hepatitis B Seroclearance upon Development of Hepatocellular Carcinoma
Keyword(s):
The spontaneous seroclearance of hepatitis B upon development of a hepatocellular carcinoma (HCC) is extremely rare. To date, there has been one published case series reporting hepatitis B seroconversion following HCC resection. We describe two novel cases of spontaneous hepatitis B seroclearance following the development of HCC, prior to resection. Following resection, specimens were HBsAg- and HBcAg-negative in both tumor and peritumor tissues. Although the precise mechanism of this is poorly understood, nonuniform integration of hepatitis B virus DNA within the liver could lead to selective tumorigenesis of HBsAg-producing cells, explaining the observed clearance of serum HBsAg with the development of HCC.
1988 ◽
Vol 62
(3)
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pp. 861-865
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2016 ◽
Vol 14
(3)
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pp. 461-468.e2
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Keyword(s):
1992 ◽
Vol 188
(1)
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pp. 344-351
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Keyword(s):