Roxadustat Improves Erythropoietin Antibody-Mediated Pure Red Cell Aplasia in a Patient with Hemodialysis

2021 ◽  
pp. 1-4
Author(s):  
Sijia Li ◽  
Xueqin Chen ◽  
Penghua Hu ◽  
Suijing Wu ◽  
Jianchao Ma ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Immunosuppressive Therapy ◽  
Recombinant Human Erythropoietin ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Common Complication ◽  
Normal Range ◽  
Red Cell Aplasia ◽  
Human Erythropoietin

Anemia is a common complication of chronic kidney disease (CKD). Recombinant human erythropoietin (rHu-EPO) is used extensively in patients with CKD. However, anti-erythropoietin (anti-EPO) antibody has been reported during rHu-EPO treatment, which causes pure red cell aplasia (PRCA). We presented a case of 75-year-old man, who underwent hemodialysis for 2 years. He developed PRCA during rHu-EPO treatment. The rHu-EPO was immediately discontinued, and the patient was given roxadustat treatment. After 6 months of roxadustat treatment, the anti-EPO antibody was disappeared, and hemoglobin recovered normal range. The results suggest that roxadustat can be used to treat patients with anti-EPO antibody-mediated PRCA without immunosuppressive therapy.

scholarly journals Epoetin-associated pure red cell aplasia in patients with chronic kidney disease: solving the mystery

2005 ◽  
Vol 20 (suppl_3) ◽  
pp. iii33-iii40 ◽  
Author(s):  
Katia Boven ◽  
John Knight ◽  
Fred Bader ◽  
Jérome Rossert ◽  
Kai-Uwe Eckardt ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia

Hypersensitivity Syndrome and Pure Red Cell Aplasia Following Allopurinol Therapy in a Patient with Chronic Kidney Disease

2005 ◽  
Vol 39 (9) ◽  
pp. 1552-1556 ◽  
Author(s):  
Sheau-Chiou Chao ◽  
Chao-Chun Yang ◽  
Julia Yu-Yun Lee
Keyword(s):  
Chronic Kidney Disease ◽  
Bone Marrow ◽  
Drug Reaction ◽  
Kidney Disease ◽  
Hypersensitivity Syndrome ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Probability Scale ◽  
Naranjo Probability Scale ◽  
Red Cell Aplasia

OBJECTIVE: To report a rare case of combined hypersensitivity syndrome and pure red cell aplasia (PRCA) following allopurinol therapy. CASE SUMMARY: A 43-year-old woman with underlying mesangioproliferative glomerulonephritis developed fever, generalized morbilliform rash, leukocytosis with marked eosinophilia, and hepatic dysfunction 3 weeks after starting allopurinol therapy (300 mg/day for 3 days followed by 200 mg/day) for hyperuricemia and arthritis. The clinical findings were judged to be a probable drug reaction according to the Naranjo probability scale. The drug-induced hypersensitivity syndrome (DHS) resolved after withdrawal of allopurinol and initiation of systemic corticosteroid therapy. However, there was progressive worsening of anemia with reticulocytopenia; PRCA was suspected. PRCA was judged to be a possible drug reaction according to the Naranjo probability scale. The patient refused blood transfusion and bone marrow biopsy. Recombinant human erythropoietin was initiated in addition to prednisolone 15 mg daily. Eleven days later (~7 wk after allopurinol withdrawal), both the hemoglobin level and reticulocyte count began to rise. The patient consented to a bone marrow study at that time, which confirmed the presence of dysplasia involving only the erythroid lineage. DISCUSSION: Allopurinol may induce DHS, aplastic anemia, and, in rare instances, PRCA. We report the first case of PRCA concurrent with allopurinol-induced DHS in a patient with chronic kidney disease. Discontinuation of allopurinol is the first step in the treatment of such cases. The slow recovery of PRCA might be partly attributed to her underlying chronic kidney disease. CONCLUSIONS: To minimize serious DHS, proper indications for treatment and dosage adjustment should be closely observed when starting allopurinol therapy in patients with chronic kidney disease.

scholarly journals Epoetin-associated pure red cell aplasia in patients with chronic kidney disease: solving the mystery

2006 ◽  
Vol 21 (9) ◽  
pp. 2678-2678
Author(s):  
Katia Boven ◽  
John Knight ◽  
Fred Bader ◽  
Jérome Rossert ◽  
Kai-Uwe Eckardt ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia

Pure Red Cell Aplasia Induced Only by Intravenous Administration of Recombinant Human Erythropoietin

2011 ◽  
Vol 126 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Hiroaki Shimizu ◽  
Takayuki Saitoh ◽  
Fumie Ota ◽  
Takahiro Jimbo ◽  
Yoshito Tsukada ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Recombinant Human Erythropoietin ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia ◽  
Human Erythropoietin
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