scholarly journals Usefulness of Quantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography for Evaluating the Treatment Response of Bone Metastasis in a Lung Cancer Patient

2021 ◽  
pp. 391-396
Author(s):  
Kazuhiro Kitajima ◽  
Tatsuya Tsuchitani ◽  
Yoshiyuki Takahashi ◽  
Toshiyuki Minami ◽  
Takashi Yokoi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Femur Head ◽  
Bone Spect ◽  
Single Photon Emission Computed ◽  
The Right ◽  
Photon Emission Computed Tomography

We report a case of bone metastasis arising from lung cancer, including quantitative values obtained with bone single-photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate the treatment response. The first bone SPECT/CT during pembrolizumab therapy for lung cancer recurrence showed intense 99mTc-HMDP uptake of the right femur head and mild uptake of the left ribs. After the palliative radiotherapy for the right femur head metastasis and chemotherapy, the second bone SPECT/CT showed a decrease in focal uptake of the right femur hip and increasing uptake of the left ribs. There was also new uptake appearance in the sternum, right rib, spine (Th2, Th9, Th12, L4, S1), and bilateral pelvic bone (left ilium, acetabular cartridge, femur, right ilium and ischium). The change of maximum standardized uptake values (SUVmax) for the right femur head and left third and eighth rib bony metastases were −72.6% (from 22.96 to 6.28), +407.7% (from 2.97 to 15.08), and +229.2% (from 2.60 to 8.56), respectively. The change of whole-lesion metabolic bone volume and total bone uptake was +235.4% (from 22.75 to 76.3 cm3) and +219.1% (from 205.0 to 654.09), respectively. Two quantitative bone SPECT/CT images clearly showed the good response of femur head metastasis due to radiotherapy, and progression of other bone metastases regardless of chemotherapy.

scholarly journals Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hironobu Hata ◽  
Tomoka Kitao ◽  
Jun Sato ◽  
Takuya Asaka ◽  
Kenji Imamachi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Parietal Bone ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Bone Spect ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Effects of long-term bisphosphonate (BP) administration on the metabolism of healthy bone and the concomitant changes in imaging are unclear. Hence, we aimed to retrospectively investigate the effects of long-term BP administration on the intact parietal bone using the standardised uptake value (SUV) derived from single photon emission computed tomography (SPECT). We enrolled 29 patients who had odontogenic infection, osteoporosis, bone metastasis cancer, or rheumatoid arthritis, and classified them into BP-naïve: A (14 patients) and BP-treated: B, < 4 years (7 patients) and C, ≥ 4 years (8 patients) groups. We measured the maximum bilateral SUV (SUVmax) of the parietal bone using quantitative bone SPECT software. There were significant differences in the duration of BP administration and SUVmax of the parietal bone among the diseases (P < 0.0001 and P = 0.0086, respectively). There was a positive correlation between the duration of BP administration and SUVmax of the parietal bone (rs = 0.65, P = 0.0002). The SUVmax was significantly different between A and B (P = 0.02) and between A and C (P = 0.0024) groups. This is the first report on the correlation between long-term BP administration and the SUVmax of the parietal bone using the quantitative bone SPECT analysis.

scholarly journals Ectopic Submandibular Parathyroid Adenoma by Tc-99m Sestamibi SPECT/CT Localization

2020 ◽  
Vol 10 ◽  
pp. 61
Author(s):  
Fung Him Ng ◽  
King Shing Yung ◽  
Wing Hang Luk
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Planar Imaging ◽  
Single Photon Emission ◽  
Inferior Aspect ◽  
Single Photon Emission Computed ◽  
The Right ◽  
Photon Emission Computed Tomography

We present a 74-year-old woman with primary hyperparathyroidism, with elevated parathyroid hormone and calcium. Tc-99m-methoxyisobutyl isonitrile (sestamibi) planar imaging showed a focus of uptake over the inferior aspect of the right submandibular gland that was localized on the single-photon emission computed tomography with CT.

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