scholarly journals ІНФОРМАЦІЙНІ ТЕХНОЛОГІЇ В ОЦІНЦІ ЕФЕКТИВНОСТІ ЗАСТОСУВАННЯ ПРЕІМПЛАНТАЦІЙНОЇ ДІАГНОСТИКИ В ПРАКТИЦІ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ

Author(s):  
S. V. Denysenko

Application of the information technologies is becoming increasingly important in the practice of molecular and cytogenetic analysis of chromosomal abnormalities in particular on the preimplantation level. Capacity of preimplantation diagnosis is based on fluorescent in situ hybridization (FISH) and comparative genomic hybridization (CGH). Interpretation of FISH/CGH results is performed with the help of Applied Cytovision System.

2006 ◽  
Vol 130 (7) ◽  
pp. 967-974
Author(s):  
Carl Morrison

Abstract During the past few years a new high-throughput molecular technology, array comparative genomic hybridization, has received a great deal of attention. As a DNA-based tool, this technique is presumably more reproducible than expression arrays. In this review, I discuss how array comparative genomic hybridization is remarkably similar with regard to genome analysis to fluorescent in situ hybridization, a technique that is generally regarded as one of the more accurate and reproducible molecular techniques in diagnostic surgical pathology. A thorough understanding of this technology will be useful for all surgical pathologists in the near future, as this technology will no doubt have some influence on our daily practice.


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