scholarly journals Staged reperfusion attenuates myocardial stunning in dogs. Role of transient acidosis during early reperfusion.

Circulation ◽  
1991 ◽  
Vol 84 (5) ◽  
pp. 2135-2145 ◽  
Author(s):  
M Hori ◽  
M Kitakaze ◽  
H Sato ◽  
S Takashima ◽  
K Iwakura ◽  
...  
Keyword(s):  
Myocardial Stunning ◽  
Early Reperfusion

Role of leukocyte accumulation and oxygen radicals in ischemia-reperfusion-induced injury in skeletal muscle

2001 ◽  
Vol 280 (4) ◽  
pp. H1716-H1721 ◽  
Author(s):  
M. G. Schlag ◽  
K. A. Harris ◽  
R. F. Potter
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Radicals ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Male Rats ◽  
Reactive Oxygen Metabolites ◽  
Early Reperfusion ◽  
Reperfusion Period ◽  
Highly Correlated

The role of leukocytes and nonleukocyte-derived reactive oxygen metabolites (ROMs) in reperfusion-induced skeletal muscle injury was determined. Male rats received 2 h no-flow hindlimb ischemia-reperfusion (I/R, n = 6) or were rendered neutropenic via antineutrophil serum (ANS) before I/R (I/R + ANS, n = 5). Oxygen radicals in the absence of neutrophils were tested by administration of dimethylthiourea (DMTU) (I/R + ANS + DMTU, n = 5). Perfused capillaries (CDper) and rolling (Lr), adherent (La), and extravasated leukocytes (Le) in the extensor digitorum longus muscle were measured every 15 min during 90 min of reperfusion using intravital microscopy. The vital dyes bisbenzimide (BB) and ethidium bromide (EB) provided direct measures of tissue injury (EB/BB). CDper decreased immediately on reperfusion in the I/R and I/R + ANS groups. CDper in the I/R + ANS + DMTU group remained at baseline throughout reperfusion. La increased in the I/R group; however, EB/BB was the same between I/R and I/R + ANS groups. Injury in the I/R + ANS + DMTU group did not differ from other groups ≥60 min, after which EB/BB became significantly lower. Le did not differ between groups and was highly correlated to tissue injury. The results suggest that Le lead to parenchymal injury, and ROMs lead to perfusion deficits during the early reperfusion period after ischemia.

scholarly journals Bifunctional Role of Protein Tyrosine Kinases in Late Preconditioning Against Myocardial Stunning in Conscious Rabbits

1999 ◽  
Vol 85 (12) ◽  
pp. 1154-1163 ◽  
Author(s):  
Buddhadeb Dawn ◽  
Yu-Ting Xuan ◽  
Yumin Qiu ◽  
Hitoshi Takano ◽  
Xian-Liang Tang ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Myocardial Stunning ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine ◽  
Late Preconditioning ◽  
Conscious Rabbits

Early reperfusion and clinical outcomes in patients with M2 occlusion: pooled analysis of the PROACT II, IMS, and IMS II studies

2014 ◽  
Vol 121 (6) ◽  
pp. 1354-1358 ◽  
Author(s):  
Ralph Rahme ◽  
Sharon D. Yeatts ◽  
Todd A. Abruzzo ◽  
Lincoln Jimenez ◽  
Liqiong Fan ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Functional Independence ◽  
Pooled Analysis ◽  
Modified Rankin Scale ◽  
Early Reperfusion ◽  
Glucose Levels ◽  
Significant Difference ◽  
Baseline Characteristics ◽  
The Impact

Object The role of endovascular therapy in patients with acute ischemic stroke and a solitary M2 occlusion remains unclear. Through a pooled analysis of 3 interventional stroke trials, the authors sought to analyze the impact of successful early reperfusion of M2 occlusions on patient outcome. Methods Patients with a solitary M2 occlusion were identified from the Prolyse in Acute Cerebral Thromboembolism (PROACT) II, Interventional Management of Stroke (IMS), and IMS II trial databases and were divided into 2 groups: successful reperfusion (thrombolysis in cerebral infarction [TICI] 2–3) at 2 hours and failed reperfusion (TICI 0–1) at 2 hours. Baseline characteristics and clinical outcomes were compared. Results Sixty-three patients, 40 from PROACT II and 23 from IMS and IMS II, were identified. Successful early angiographic reperfusion (TICI 2–3) was observed in 31 patients (49.2%). No statistically significant difference in the rates of intracerebral hemorrhage (60.9% vs 47.6%, p = 0.55) or mortality (19.4% vs 15.6%, p = 0.75) was observed. However, there was a trend toward higher incidence of symptomatic hemorrhage in the TICI 2–3 group (17.4% vs 0%, p = 0.11). There was also a trend toward higher baseline glucose levels in this group (151.5 mg/dl vs 129.6 mg/ dl, p = 0.09). Despite these differences, the rate of functional independence (modified Rankin Scale Score 0–2) at 3 months was similar (TICI 2–3, 58.1% vs TICI 0–1, 53.1%; p = 0.80). Conclusions A positive correlation between successful early reperfusion and clinical outcome could not be demonstrated for patients with M2 occlusion. Irrespective of reperfusion status, such patients have better outcomes than those with more proximal occlusions, with more than 50% achieving functional independence at 3 months.

scholarly journals Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts.

1988 ◽  
Vol 82 (3) ◽  
pp. 920-927 ◽  
Author(s):  
M Kitakaze ◽  
M L Weisfeldt ◽  
E Marban
Keyword(s):  
Myocardial Stunning ◽  
Early Reperfusion

scholarly journals Myocardial Stunning After Electrocution With Complete Reversibility Within 24 Hours: Role of Repeat Transthoracic Echocardiograms in Potential Cardiac Transplant Donors

2018 ◽  
Vol 9 (4) ◽  
pp. 268-272
Author(s):  
Hassan Tahir ◽  
Sarina Sachdev ◽  
Landai Nguyen ◽  
Nikky Bardia ◽  
Bassam Omar ◽  
...  
Keyword(s):  
Myocardial Stunning ◽  
Cardiac Transplant
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