scholarly journals Effects of Hsp70.1 Gene Knockout on the Mitochondrial Apoptotic Pathway After Focal Cerebral Ischemia

Stroke ◽  
2004 ◽  
Vol 35 (9) ◽  
pp. 2195-2199 ◽  
Author(s):  
Seung-Hoon Lee ◽  
Hyung-Min Kwon ◽  
Young-Ju Kim ◽  
Kyung-Mi Lee ◽  
Manho Kim ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Gene Knockout ◽  
Apoptotic Pathway ◽  
Mitochondrial Apoptotic Pathway

scholarly journals Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94

2000 ◽  
Vol 20 (12) ◽  
pp. 1681-1689 ◽  
Author(s):  
Minoru Asahi ◽  
Kazuko Asahi ◽  
Jae-Chang Jung ◽  
Gregory J. del Zoppo ◽  
M. Elizabeth Fini ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Knockout Mice ◽  
Focal Cerebral Ischemia ◽  
Gene Knockout ◽  
Focal Ischemia ◽  
Lesion Size ◽  
Wild Type ◽  
Systemic Hemodynamic ◽  
Ischemic Lesion ◽  
Mmp Inhibitor

It has been shown recently that matrix metalloproteinases (MMPs) are elevated after cerebral ischemia. In the current study, we investigated the pathophysiologic role for MMP-9 (gelatinase B, EC.3.4.24.35) in a mouse model of permanent focal cerebral ischemia, using a combination of genetic and pharmacologic approaches, Zymography and Western blot analysis demonstrated that MMP-9 protein levels were rapidly up-regulated in brain after ischemic onset. Reverse transcription polymerase chain reaction showed increased transcription of MMP-9. There were no differences in systemic hemodynamic parameters and gross cerebrovascular anatomy between wild type mice and mutant mice with a targeted knockout of the MMP-9 gene. After induction of focal ischemia, similar reductions in cerebral blood flow were obtained. In the MMP-9 knockout mice, ischemic lesion volumes were significantly reduced compared with wild type littermates in male and female mice. In normal wild type mice, the broad spectrum MMP inhibitor BB-94 (batimastat) also significantly reduced ischemic lesion size, However, BB-94 had no detectable protective effect when administered to MMP-9 knockout mice subjected to focal cerebral ischemia. These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia.

scholarly journals CD47 gene knockout protects against transient focal cerebral ischemia in mice

2009 ◽  
Vol 217 (1) ◽  
pp. 165-170 ◽  
Author(s):  
Guang Jin ◽  
Kiyoshi Tsuji ◽  
Changhong Xing ◽  
Yong-Guang Yang ◽  
Xiaoying Wang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Gene Knockout ◽  
Transient Focal Cerebral Ischemia

PPAR-γ agonist rosiglitazone decreases focal cerebral ischemia-induced inflammation and brain damage in adult mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S94-S94
Author(s):  
Kudret Tureyen ◽  
Ramya Sundaresan ◽  
Kellie Bowen ◽  
Raghu Vemuganti
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Adult Mice ◽  
Ppar Γ

Negative neurovascular coupling during anoxic depolarization and peri-infarct spreading depressions in acute focal cerebral ischemia in mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S425-S425
Author(s):  
Cenk Ayata ◽  
Hwa Kyoung Shin ◽  
Phillip Jones ◽  
Andrew K Dunn ◽  
David A Boas ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neurovascular Coupling ◽  
Anoxic Depolarization
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