scholarly journals Reduced Stretch-Induced Force Response in Failing Human Myocardium Caused by Impaired Na+-Contraction Coupling

2009 ◽  
Vol 2 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Dirk von Lewinski ◽  
Jens Kockskämper ◽  
Danan Zhu ◽  
Heiner Post ◽  
Andreas Elgner ◽  
...  
Keyword(s):  
Human Myocardium ◽  
Force Response ◽  
Contraction Coupling

Calcium release from cardiac sarcoplasmic reticulum induced by photorelease of calcium or Ins(1,4,5)P3

1990 ◽  
Vol 258 (2) ◽  
pp. H610-H615 ◽  
Author(s):  
J. C. Kentish ◽  
R. J. Barsotti ◽  
T. J. Lea ◽  
I. P. Mulligan ◽  
J. R. Patel ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Cardiac Muscle ◽  
Calcium Release ◽  
Force Response ◽  
Cardiac Sarcoplasmic Reticulum ◽  
Excitation Contraction Coupling ◽  
Caged Compounds ◽  
Contraction Coupling ◽  
Inositol 1,4,5 Trisphosphate ◽  
Ventricular Trabeculae

The ability of Ca2+ or inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] to release Ca2+ from cardiac sarcoplasmic reticulum (SR) was investigated using saponin-skinned ventricular trabeculae from rats. To overcome diffusion delays, rapid increases in the concentrations of Ca2+ and Ins(1,4,5)P3 were produced by laser photolysis of “caged Ca2+” (Nitr-5) and “caged Ins(1,4,5)P3”. Photolysis of Nitr-5 to produce a small jump in [Ca2+] from pCa 6.8 to 6.4 induced a large and rapid force response (t1/2 = 0.89 s at 12 degrees C); the source of the Ca2+ that activated the myofibrils was judged to be the SR, since it was blocked by 0.1 mM ryanodine or 5 mM caffeine. A smaller, slower, and less consistent release of SR Ca2+ was produced by photorelease of Ins(1,4,5)P3. The results demonstrate that these caged compounds can be used to study excitation-contraction coupling in skinned multicellular preparations of cardiac muscle. The data are consistent with a major role for Ca2(+)-induced Ca2+ release in cardiac activation, whereas the role for Ins(1,4,5)P3 may be to modulate, rather than directly stimulate, SR Ca2+ release.

scholarly journals Functional Relevance of the Stretch-Dependent Slow Force Response in Failing Human Myocardium

2004 ◽  
Vol 94 (10) ◽  
pp. 1392-1398 ◽  
Author(s):  
Dirk von Lewinski ◽  
Burkhard Stumme ◽  
Florian Fialka ◽  
Claus Luers ◽  
Burkert Pieske
Keyword(s):  
Human Myocardium ◽  
Force Response ◽  
Functional Relevance

11 Inotropic effects of insulin in failing human myocardium

2003 ◽  
Vol 2 (1) ◽  
pp. 2
Author(s):  
D VONLEWINSKI ◽  
S BRUNS ◽  
E BISPING ◽  
B PIESKE
Keyword(s):  
Human Myocardium ◽  
Inotropic Effects

453 Contractile property alterations in failing human myocardium after treatments by amiodarone

2006 ◽  
Vol 5 (1) ◽  
pp. 109-109
Author(s):  
D KONDRATEVA ◽  
S AFANASEV ◽  
A EVTUSHENKO ◽  
V EVTUSHENKO ◽  
S POPOV ◽  
...  
Keyword(s):  
Human Myocardium ◽  
Contractile Property

Passive force in left ventricular human myocardium is not passive

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
I Karliova ◽  
L Hakami ◽  
AA Peivandi ◽  
N Kayhan ◽  
U Mehlhorn ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Human Myocardium ◽  
Passive Force
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