Co-effect of aqueous solubility of drugs and glycolide monomer on in vitro release rates from poly(D,L-lactide- co-glycolide) discs and polymer degradation

2005 ◽  
Vol 16 (8) ◽  
pp. 991-1007 ◽  
Author(s):  
Jong Min Kim ◽  
Kwang Su Seo ◽  
Yong Kyun Jeong ◽  
Hai Bang Lee ◽  
Yong Sik Kim ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Polymer Degradation ◽  
Aqueous Solubility ◽  
Release Rates ◽  
Vitro Release

scholarly journals Comparison of In Vitro Release Rates of Diclofenac Topical Formulations Using an In-Line Cell Automated Diffusion System

2019 ◽  
Vol 26 (4) ◽  
pp. 10-16
Author(s):  
Yogesh Upadhyay ◽  
Abhishek Kumar Singh ◽  
Sanjeev Mishra ◽  
Sanjay Jagannath Gurule ◽  
Arshad H. Khuroo ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Diffusion System ◽  
Release Rates ◽  
Topical Formulations ◽  
Vitro Release

Matrix Vaginal Ring Formulations that Maintain Target In Vitro Release Rates of Dapivirine and Levonorgestrel (Alone or in Combination) over 90 Days

2014 ◽  
Vol 30 (S1) ◽  
pp. A138-A139 ◽  
Author(s):  
Jonathon Holt ◽  
Andrew Brimer ◽  
Susan Fetherston ◽  
Peter Boyd ◽  
Brid Devlin ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Vaginal Ring ◽  
Release Rates ◽  
Vitro Release

scholarly journals Improvement of In vitro release of Glibenclamide using Cyclodextrin inclusion complexation

2015 ◽  
Vol 13 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Neelkant Prasad ◽  
Navneet Garud ◽  
Akanksha Garud
Keyword(s):  
Complex Formation ◽  
Oral Absorption ◽  
In Vitro Release ◽  
Inclusion Complexation ◽  
Aqueous Solubility ◽  
Scanning Calorimetry ◽  
Hypoglycemic Agent ◽  
Cyclodextrin Inclusion ◽  
Vitro Release

The present study aimed to improve the aqueous solubility of the oral hypoglycemic agent, glibenclamide (GLI), so as to improve its oral absorption, and hence bioavailability after oral administration. This was accomplished by complex formation between GLI and ?-cyclodextrin (?-CD). The study involves the preparation of the inclusion complexes using different techniques. Differential Scanning Calorimetry (DSC) and XRay Diffractometry (XRD) results confirmed the complex formation between GLI and ?-CD. The solubility increase of GLI was due to 1:1 complex formation. The dissolution rate of GLI from the complex prepared by neutralization method was more rapid as compared to other methods used. DOI: http://dx.doi.org/10.3329/dujps.v13i1.21855 Dhaka Univ. J. Pharm. Sci. 13(1): 15-21, 2014 (June)

scholarly journals Impairment of the in vitro Release of Carbamazepine from Tablets

2010 ◽  
Vol 10 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Alija Uzunović ◽  
Edina Vranić ◽  
Šeherzada Hadžidedić
Keyword(s):  
Dissolution Rate ◽  
In Vitro Release ◽  
Aqueous Solubility ◽  
Immediate Release ◽  
Point Of View ◽  
Dissolution Profile ◽  
Poorly Soluble ◽  
Per Oral ◽  
Vitro Release

Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. The bioavailability of such a drug is limited by the dissolution rate. The present study deals with the formulations of immediate release tablets of poorly soluble carbamazepine. As model tablets for this investigation, two formulations (named “A” and “B” formulations) of carbamazepine tablets labeled to contain 200 mg were evaluated. The aim of this study was to establish possible differences in dissolution profile of these two formulations purchased from the local market.The increased crystallinity together with enlarged particle size, enhanced aggregation and decreased wettability of the drug, resulted in insufficient dissolution rate for formulation “B’.’ From the dissolution point of view, this formulation was inferior to the formulation “A, due to the solubilization effect.

scholarly journals Comparison of In Vitro Release Rates of Acyclovir from Cream Formulations Using Vertical Diffusion Cells

2014 ◽  
Vol 15 (4) ◽  
pp. 994-999 ◽  
Author(s):  
Sumalatha Nallagundla ◽  
Srinivas Patnala ◽  
Isadore Kanfer
Keyword(s):  
In Vitro Release ◽  
Release Rates ◽  
Vertical Diffusion ◽  
Diffusion Cells ◽  
Vitro Release
Sign in / Sign up

Export Citation Format

Share Document