Abstract
Background The purpose of the study is to examine whether the adaptive support ventilation (ASV) mode compared with conventional ventilation reduces the duration of mechanical ventilation (MV) in patients with acute respiratory failure. Methods We searched PubMed, the Cochrane Library Central Register of Controlled Trials, EMBASE and Web of Science databases from inception through July 27, 2019. We considered all the randomized controlled studies (RCTs) that examined the efficacy of ASV in comparison with conventional ventilation in mechanically ventilated adults. The primary outcomes were (1) the length of MV, (2) weaning duration and (3) length of stay (LOS) in ICU. Results We included three RCTs for the analysis enrolling a total of 374 patients. Patients treated with ASV had a lower weaning duration than patients treated with conventional ventilation (MD -28.98 [95% CI -42.42, -15.54, p˂0.0001]). Then, 28-day mortality was not different between the two groups (OR 0.95 [95%CI 0.6, 1.52, p=0.83; I2=0%, p=0.96]). The incidence of ventilator-associated pneumonia and sedation level was not included into the quantitative analysis. Conclusions The study showed that a lower number of duration of MV and a shorter number of weaning duration in acute hypoxemic respiratory failure patients treated with ASV than conventional ventilation. Keywords: pulmonary infection; critically ill patients; adaptive support ventilation; hypoxemic respiratory failure Background Acute hypoxemic respiratory failure is a severe disorder of the respiratory system to maintain oxygenation or eliminate carbon dioxide (CO2), leading to a series of metabolic disorders and physiological dysfunction. Mechanical ventilation (MV) serve as a lifesaving therapy is widely employed in intensive care units (ICU) for treating clinical symptoms related to critically illness.[1,2] Employment of mechanical ventilation in patients could help effectively to replace, control and change spontaneous breathing, reduce or eliminate respiratory muscle oxygen consumption, increasing ventilation and improving ventilation[3], removing the residual mucous in airway.[4] The choice of ventilation mode is such a very important issue in ICU that clinicians capable to choose the ventilation mode and adapt the ventilator controls according to the patient's respiratory mechanics.
Feasibility study on full closed-loop control ventilation (IntelliVent-ASV™) in ICU patients with acute respiratory failure: a prospective observational comparative study
