Progressive Subglottic Stenosis In A Child-could It Be Seronegative Isolated Wegener's Granulomatosis?

Author(s):  
Pravin K. Sah ◽  
Syboney Zapata ◽  
Dawn Simon
2000 ◽  
Vol 19 (4) ◽  
pp. 315-317 ◽  
Author(s):  
I. Stappaerts ◽  
C. Van Laer ◽  
K. Deschepper ◽  
P. Van de Heyning ◽  
P. Vermeire

2001 ◽  
Vol 7 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Mayra Guerrero ◽  
Eric Gall ◽  
Ermias Tilahun ◽  
Jack Garon

2007 ◽  
Vol 48 (5) ◽  
pp. 748 ◽  
Author(s):  
Jacob Shvero ◽  
David Shitrit ◽  
Rumelia Koren ◽  
Dekel Shalomi ◽  
Mordechai Reuven Kramer

1989 ◽  
Vol 103 (12) ◽  
pp. 1187-1191 ◽  
Author(s):  
T. J. Hoare ◽  
D. Jayne ◽  
P. Rhys Evans ◽  
C. B. Croft ◽  
D. J. Howard

AbstractWegener's granulomatosis is difficult to diagnose, especially when the presentation is unusual, restricted to an isolated region. We report four cases of recurrent subglottic stenosis posing difficulty in diagnosis. In each case the finding of anti-neutrophil cytoplasm antibodies (ANCA) strongly suggested an underlying vasculitic pathology, Wegener's granulomatosis. We discuss reasons for the difficulty in diagnosis in the past, the possible role of the ANCA assay in such patients, and suggest it should be more widely used in the future.


2009 ◽  
Vol 124 (4) ◽  
pp. 393-396 ◽  
Author(s):  
A C Church ◽  
K Goldsmith ◽  
P Sivasothy

AbstractObjective:In patients with Wegener’s granulomatosis, subglottic stenosis can develop due to active disease; however, some patients develop subglottic stenosis with no clear evidence of airway inflammation. In some cases of idiopathic subglottic stenosis, an association with gastroesophageal reflux disease has been found. Our study assessed the potential role of gastroesophageal reflux as an aetiological factor in the development of subglottic stenosis in patients with Wegener’s granulomatosis.Design:We assessed evidence of active reflux disease, using 24-hour pH monitoring and assessment of bile salts in bronchoalveolar lavage fluid.Subjects:Ten Wegener’s granulomatosis patients with subglottic stenosis underwent 24-hour pH monitoring and bronchoscopy and lavage of the right middle lobe. A similar number of control patients were included.Results:There was no statistically significant difference in the occurrence of bronchoalveolar bile salts in patients with subglottic stenosis (n = 2) versus control patients (zero) (p = 0.457). There was good correlation between the detection of reflux by 24-hour pH monitoring and the detection of bronchoalveolar bile salts (κ = 0.769).Conclusion:In this small study of patients with Wegener’s granulomatosis, there was no evidence of an association between the development of subglottic stenosis and gastroesophageal reflux.


1996 ◽  
Vol 39 (10) ◽  
pp. 1754-1760 ◽  
Author(s):  
Carol A. Langford ◽  
Michael C. Sneller ◽  
Claire W. Hallahan ◽  
Gary S. Hoffman ◽  
William A. Kammerer ◽  
...  

2008 ◽  
Vol 17 (2) ◽  
pp. 114-116 ◽  
Author(s):  
Allen J Blaivas ◽  
Walter Strauss ◽  
Michael Yudd

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