L-Carbocisteine Inhibits Respiratory Syncytial Virus Infection In Human Airway Epithelial Cells

2012 ◽  
Author(s):  
Mutsuo Yamaya ◽  
Yukimasa Hatachi ◽  
Hiroshi Kubo ◽  
Hidekazu Nishimura
Keyword(s):  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Syncytial Virus ◽  
Human Airway Epithelial Cells

scholarly journals Mutation of Respiratory Syncytial Virus G Protein’s CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells

Vaccines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 69 ◽  
Author(s):  
Binh Ha ◽  
Tatiana Chirkova ◽  
Marina S. Boukhvalova ◽  
He Ying Sun ◽  
Edward E. Walsh ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Host Responses ◽  
Airway Epithelial ◽  
Live Virus ◽  
Human Airway ◽  
Cotton Rats ◽  
Syncytial Virus ◽  
Human Airway Epithelial Cells

Despite being a high priority for vaccine development, no vaccine is yet available for respiratory syncytial virus (RSV). A live virus vaccine is the primary type of vaccine being developed for young children. In this report, we describe our studies of infected cotton rats and primary human airway epithelial cells (pHAECs) using an RSV r19F with a mutation in the CX3C chemokine motif in the RSV G protein (CX4C). Through this CX3C motif, RSV binds to the corresponding chemokine receptor, CX3CR1, and this binding contributes to RSV infection of pHAECs and virus induced host responses that contribute to disease. In both the cotton rat and pHAECs, the CX4C mutation decreased virus replication and disease and/or host responses to infection. Thus, this mutation, or other mutations that block binding to CX3CR1, has the potential to improve a live attenuated RSV vaccine by attenuating both infection and disease pathogenesis.

scholarly journals Role of CCR3 in Respiratory Syncytial Virus infection of Airway Epithelial Cells

iScience ◽  
2021 ◽  
pp. 103433
Author(s):  
Vincent Wellemans ◽  
Hassan Ait Benhassou ◽  
Eloise Fuselier ◽  
Fabienne Bellesort ◽  
Sandra Dury ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Syncytial Virus
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