Skeletal Muscle Weakness Is Associated with Specific Alterations in Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease

2019 ◽  
Author(s):  
C. Cruthirds ◽  
J.J. Thaden ◽  
G.A.M. Ten Have ◽  
N.E.P. Deutz ◽  
M.P.K.J. Engelen
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Amino Acid ◽  
Pulmonary Disease ◽  
Muscle Weakness ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Skeletal Muscle Weakness

Effects of Exercise on Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease

2001 ◽  
Vol 163 (4) ◽  
pp. 859-864 ◽  
Author(s):  
MARIËLLE P. K. J. ENGELEN ◽  
EMIEL F. M. WOUTERS ◽  
NICOLAAS E. P. DEUTZ ◽  
JOAN D. DOES ◽  
ANNEMIE M. W. J. SCHOLS
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Amino Acid ◽  
Pulmonary Disease ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Musculoskeletal Disorders in Chronic Obstructive Pulmonary Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Nele Cielen ◽  
Karen Maes ◽  
Ghislaine Gayan-Ramirez
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Pulmonary Disease ◽  
Muscle Weakness ◽  
Negative Impact ◽  
Functional Decline ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Skeletal Muscle Weakness ◽  
Impaired Health

Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by airway obstruction and inflammation but also accompanied by several extrapulmonary consequences, such as skeletal muscle weakness and osteoporosis. Skeletal muscle weakness is of major concern, since it leads to poor functional capacity, impaired health status, increased healthcare utilization, and even mortality, independently of lung function. Osteoporosis leads to fractures and is associated with increased mortality, functional decline, loss of quality of life, and need for institutionalization. Therefore, the presence of the combination of these comorbidities will have a negative impact on daily life in patients with COPD. In this review, we will focus on these two comorbidities, their prevalence in COPD, combined risk factors, and pathogenesis. We will try to prove the clustering of these comorbidities and discuss possible preventive or therapeutic strategies.

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