scholarly journals IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

2011 ◽  
Vol 183 (7) ◽  
pp. 865-875 ◽  
Author(s):  
Jennifer Kearley ◽  
Jonas S. Erjefalt ◽  
Cecilia Andersson ◽  
Ebony Benjamin ◽  
Carla P. Jones ◽  
...  
2002 ◽  
Vol 29 (4) ◽  
pp. 232-237 ◽  
Author(s):  
◽  
María-Teresa Fernández-Figueras ◽  
Isabel Bielsa ◽  
Betlem Lloveras ◽  

Dermatology ◽  
1989 ◽  
Vol 178 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Wakio Torinuki ◽  
Kazuhiro Kudoh ◽  
Hachiro Tagami

1995 ◽  
Vol 146 (1) ◽  
pp. 15-21 ◽  
Author(s):  
R Aguilar ◽  
F Antón ◽  
C Bellido ◽  
E Aguilar ◽  
F Gaytan

Abstract Testicular serotonin (5HT) concentrations were determined by HPLC in the testes of rats treated neonatally with oestradiol benzoate (EB) and in adult rats treated with the Leydig cell cytotoxic ethylene dimethane sulphonate (EDS). 5HT concentrations were related to mast cell numbers. EB-treated rats showed an accumulation of mast cells in the testes at 35 and 70 days of age and increased 5HT concentrations in both the interstitial fluid and the testicular capsule, whereas no increases in 5HT concentrations or in the number of mast cells were found for the ventral prostate of these animals. On the contrary, 5HT concentrations were not related to the number of Leydig cells. In EB-treated rats, in which Leydig cells were nearly absent at 35 days of age, 5HT concentrations were significantly increased. Furthermore, EDS-treated rats did not show significant changes in 5HT concentrations, in spite of the elimination of Leydig cells. These data suggest that mast cells are a major source of serotonin in the rat testis. Journal of Endocrinology (1995) 146, 15–21


1988 ◽  
Vol 65 (1) ◽  
pp. 445-451 ◽  
Author(s):  
C. R. Turner ◽  
J. Kolbe ◽  
E. W. Spannhake

In preliminary studies of antigen-induced airway inflammation, we noted an apparent increase in peribronchiolar mast cell number. Experiments were thus undertaken to investigate the nature of this migration of mast cells into the central and peripheral airway epithelium and to determine its time course. The tracheae and small airways of 10 anesthetized mongrel dogs were exposed via a bronchoscope to Ascaris suum antigen (Ag), fMet-Leu-Phe (fMLP), ovalbumin (OVA), and isotonic saline (SAL). In the central airways, all stimuli provoked a significant increase (P less than 0.05) in mast cell numbers at the base of the airway epithelium within 3 h. In the peripheral airways, only Ag aerosol stimulated a significant mast cell increase compared with unexposed tissue. In a second series of experiments, the trachea of seven dogs were exposed to 0.026, 0.26, and 2.6 micrograms of Ag. The tissue was collected at 1, 3, 6, and 10 h after exposure. In these experiments, there was a significant mast cell increase seen within 1 h but it was not dose dependent. By 6-10 h after exposure, mast cell counts were not significantly different from the unexposed condition, which is consistent with the idea that some of the cells either degranulated or migrated into the airway lumen. We conclude that mast cell migration is an acute response that can be demonstrated within 1 h of stimulation with Ag. The observation that nonimmunological stimuli may, in some cases, also stimulate mast cell movement affords the possibility that this process represents a generalized response to airway irritation.


1995 ◽  
Vol 108 (4) ◽  
pp. A159 ◽  
Author(s):  
F. Marinelli ◽  
R. Odze ◽  
G.T. Furuta ◽  
S. Spechler ◽  
B.K. Wershil

1983 ◽  
Vol 108 (2) ◽  
pp. 179-187 ◽  
Author(s):  
M.A. PERSINGER ◽  
PATRICIA LEPAGE ◽  
J.-P. SIMARD ◽  
G.H. PARKER
Keyword(s):  
Rat Skin ◽  

1997 ◽  
Vol 27 (9) ◽  
pp. 1060-1066 ◽  
Author(s):  
D. F. ANDERSON ◽  
J. D. A. MACLEOD ◽  
S. M. BADDELEY ◽  
A. S. BACON ◽  
J. I. McGILL ◽  
...  

1978 ◽  
Vol 112 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Lennart Enerbäck ◽  
Lennart Mellblom

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