Abstract
Background Quantitative analysis of brain positron-emission tomography (PET) depends on structural segmentation, which can be time-consuming and operator-dependent when performed manually. Previous automatic segmentation methods usually fitted subjects’ images onto an atlas template for group analysis, which changed the individuals’ images and affected regional PET segmentation. We proposed an automatic segmentation method, registering atlas template to subjects’ images (RATSI), which created an individual atlas template and may be more accurate for PET segmentation. We segmented two representative brain areas in twenty Parkinson disease (PD) and eight multiple system atrophy (MSA) patients performed in hybrid positron-emission tomography/magnetic resonance imaging (PET/MR). The segmentation accuracy was evaluated using the Dice coefficient (DC) and Hausdorff distance (HD). and the standardized uptake value (SUV) measurements of these two automatic segmentation methods were compared, using manual segmentation as a reference. Results The DC of RATSI increased and the HD decreased significantly (P < 0.05) compared with the traditional method in PD, while the results of one-way analysis of variance (ANOVA) found no significant differences in the SUVmean and SUVmax among the two automatic and the manual segmentation methods. Further, RATSI was used to compare regional differences in cerebral metabolism pattern between PD and MSA patients. The SUVmean in the segmented cerebellar gray matter for the MSA group was significantly lower compared with the PD group (P<0.05), which is consistent with previous reports.Conclusion The RATSI was more accurate for the caudate nucleus and putamen automatic segmentation, and can be used for regional PET analysis in hybrid PET/MR.
Intensity threshold based solid tumour segmentation method for Positron Emission Tomography (PET) images: A review
