Efficient Local Cloud-Based Solution for Liver Cancer detection using Deep Learning

Liver cancer is one the most common forms of cancer. As per statistics in 2018 published by World Health Organization, a quarter of all cancer cases are caused by infections, particularly prevalent in developing countries, including hepatitis B, which is linked to liver cancer. The mortality rate is higher in liver cancer as compared to other types of cancer. Quick and reliable diagnosis tools are of paramount importance for detecting and treating liver cancer in early stage, thus improving the likely course of a medical condition of patient. We have developed a cloud-based solution for liver tumour Segmentation, Classification and Detection in CT images based on GoogleNet architecture of Convolutional Neural Network. Experiment is carried out with training and test sets derived from TCIA repository. The results yield 96.7% accuracy for classification of tumour cells. GoogleNet architecture is used for implementation. The GoogleNet has 70,000 images in diagnosis of malignant tumor in liver cancer, providing a rich database for testing. Our algorithm has been deployed in Azure cloud.

A Novel Approach of Lung Tumor Segmentation Using a 3D Deep Convolutional Neural Network

Cancer is one of the most life-threatening diseases in the world, and lung cancer is the leading cause of death worldwide. If not detected at an early stage, the survival rate of lung cancer patients can be very low. To treat patients in later stages, one needs to analyze the tumour region. For accurate diagnosis of lung cancer, the first step is to detect and segment the tumor. In this chapter, an approach for segmentation of a lung tumour is presented. For pre-processing of lung CT images, simple image processing like morphological operations is used, and for tumour segmentation task, a 3D convolutional neural network (CNN) is used. The CNN architecture consists of a 3D encoder block followed by 3D decoder block just like U-Net but with deformable convolution blocks. For this study, two datasets have been used; one is the online-available NSCLC Radiomics dataset, and the other is collected from an Indian local hospital. The approach proposed in this chapter is evaluated in terms of dice coefficient. This approach is able to give significant results with a dice coefficient of 77.23%.

Development of 3D MRI-Based Anatomically Realistic Models of Breast Tissues and Tumours for Microwave Imaging Diagnosis

Breast cancer diagnosis using radar-based medical MicroWave Imaging (MWI) has been studied in recent years. Realistic numerical and physical models of the breast are needed for simulation and experimental testing of MWI prototypes. We aim to provide the scientific community with an online repository of multiple accurate realistic breast tissue models derived from Magnetic Resonance Imaging (MRI), including benign and malignant tumours. Such models are suitable for 3D printing, leveraging experimental MWI testing. We propose a pre-processing pipeline, which includes image registration, bias field correction, data normalisation, background subtraction, and median filtering. We segmented the fat tissue with the region growing algorithm in fat-weighted Dixon images. Skin, fibroglandular tissue, and the chest wall boundary were segmented from water-weighted Dixon images. Then, we applied a 3D region growing and Hoshen-Kopelman algorithms for tumour segmentation. The developed semi-automatic segmentation procedure is suitable to segment tissues with a varying level of heterogeneity regarding voxel intensity. Two accurate breast models with benign and malignant tumours, with dielectric properties at 3, 6, and 9 GHz frequencies have been made available to the research community. These are suitable for microwave diagnosis, i.e., imaging and classification, and can be easily adapted to other imaging modalities.

Predicting Malignant Cancer Using Machine Learning

One of the primary concerns that is also a demanding issue within the realm of medical specialism is the detection and removal of tumours. Because visualisation approaches had the drawback of being adversarial, doctors relied heavily on MRI images to provide a superior result. Pre-processing, tumour segmentation, and tumour operations are the three stages in which tumour image processing takes place. Following the acquisition of the source image, the original image is converted to grayscale. Additionally, a noise removal filter and a median filter for quality development are provided, followed by an exploration stage that yields hits orgasmic identical images. Finally, the watershed algorithm is used to complete the segmentation. This proposed methodology is useful in automatically organising reports in a short amount of time, and exploration has resulted in the removal of many less tumour parameters. Keywords: MRI Imaging, Segmentation, Watershed Algorithm.

A Radiomic Model To Classify Response To Neoadjuvant Chemotherapy in Breast Cancer

Background Medical image analysis has evolved to facilitate the development of methods for high-throughput extraction of quantitative features that can potentially contribute to the diagnostic and treatment paradigm of cancer. There is a need for further improvement in the accuracy of predictive markers of response to neo-adjuvant chemotherapy (NAC). The aim of this study was to develop a radiomic classifier to enhance current approaches to predicting the response to NAC breast cancer. Methods Data on patients treated for breast cancer with NAC prior to surgery who had a pre-NAC dynamic contrast enhanced (DCE) breast MRI were included. Response to NAC was assessed using the Miller-Payne system on the excised tumour. Tumour segmentation was carried out manually under the supervision of a consultant breast radiologist. Features were selected using least absolute shrinkage selection operator (LASSO) regression. A support vector machine (SVM) learning model was used to classify response to NAC. Results 74 patients were included. Patients were classified as having a poor response to NAC (reduction in cellularity <90%, n=44) and an excellent response (>90% reduction in cellularity, n=30). 4 radiomics features (discretized kurtosis, NGDLM contrast, GLZLM_SZE and GLZLM_ZP) were identified as pertinent predictors of response to NAC. A SVM model using these features stratified patients into poor and excellent response groups producing an AUC of 0.75. Addition of estrogen receptor (ER) status improved the accuracy of the model with an AUC of 0.811. Conclusion This study identified a radiomic classifier incorporating 4 radiomics features to augment subtype based classification of response to NAC in breast cancer.