Retinal Function in Normal and Diabetic Eyes Mapped with the Slow Flash Multifocal Electroretinogram

We describe the electroretinographic findings of a case of primary intraocular lymphoma (PIOL) wherein the patient received intravitreal injections of methotrexate (ivMTX). A 62-year-old man developed blurred vision and complained of decreased visual acuity (VA) in his right eye. Fundus examination showed vitreous opacity and multiple subretinal yellowish lesions. Optical coherence tomography (OCT) revealed subretinal and intraretinal infiltrations. The full-field electroretinogram (ffERG) showed subnormal combined rod-cone response and multifocal electroretinogram (mfERG) recorded using skin electrodes showed severe attenuation of the response compared with the other eye. Pars prana vitrectomy, phacoemulsification, and lens implantation were performed to remove the opacity, and vitreous biopsy revealed a high ratio of interleukin 10–6 (76.0). There was no systemic malignant lesion, and the patient was diagnosed with PIOL. Treatment with ivMTX (400 μg/0.1 mL) was started. One month later, the intraretinal infiltration had disappeared, and mfERG revealed recovery of the response density from the central area. Two months later, OCT showed recovery of the foveal ellipsoid and interdigitation zones, and VA recovered to 20/17; mfERG showed maintenance of macular function. However, the amplitude of a- and b-waves in the ffERG gradually decreased. Macular function recovered, but there was also a decrease in total retinal function. mfERG and ffERG recorded using skin electrodes were useful in monitoring macular and entire retinal function with repeated examinations and showed recovery and maintenance of macular function in a case of PIOL treated with ivMTX.

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Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease

Parkinson s Disease ◽

10.1155/2018/4163239 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Jiang Huang ◽

Yi Li ◽

Jianjiang Xiao ◽

Qin Zhang ◽

Guoxu Xu ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Multifocal Electroretinogram ◽

Retinal Function ◽

Spectral Domain ◽

Implicit Time ◽

Diagnostic Efficacy ◽

Macular Volume ◽

Amplitude Density ◽

Sd Oct

Background. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations. Method. Fifty-three PD patients and forty-one healthy controls were enrolled. Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT. Results. The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions. The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD. The AUC of a single parameter of either retinal function or structure was low. Both of them were higher in diagnostic value to discriminate PD patients. Conclusion. The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD. It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD.

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Influence of photodynamic therapy in choroidal neovascularization on focal retinal function assessed with the multifocal electroretinogram and perimetry1 1The authors have no proprietary interests in any of the products mentioned in this article.

Ophthalmology ◽

10.1016/s0161-6420(02)01147-8 ◽

2002 ◽

Vol 109 (10) ◽

pp. 1788-1792 ◽

Cited By ~ 26

Author(s):

Anja M Palmowski ◽

Reiner Allgayer ◽

Bernhild Heinemann-Vernaleken ◽

Klaus W Ruprecht

Keyword(s):

Photodynamic Therapy ◽

Choroidal Neovascularization ◽

Multifocal Electroretinogram ◽

Retinal Function

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The Success of Cataract Surgery and the Preoperative Measurement of Retinal Function by Electrophysiological Techniques

Journal of Ophthalmology ◽

10.1155/2015/401281 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Jing An ◽

Lei Zhang ◽

Yusheng Wang ◽

Zuoming Zhang

Keyword(s):

Cataract Surgery ◽

Multifocal Electroretinogram ◽

Retinal Function ◽

Central Point ◽

Control Group ◽

Relevant Parameter ◽

Macular Function ◽

Control Subjects ◽

Center Point ◽

Cataract Patients

Purpose. To study the effect of different electrophysiological methods to evaluate retinal function prior to cataract surgery.Methods. Cataract patients who had no significant other eye disease were chosen. VA, pattern visual evoked potential (PVEP), electroretinogram (ERG), and multifocal electroretinogram (mfERG) responses were measured from 150 cataract patients and 20 control subjects.Results. When the preoperative VA was more than 0.3 in cataract patients, the amplitude of PVEP was not significantly different between cataract and control subjects. The amplitude of central point mfERG was significantly lower in cataract patients compared with control group from HM to 0.8 of preoperative VA. The 95% confidence intervals (CIs) of the amplitudes of center point mfERG were calculated for a range of preoperative VA values. Most of the patients within 95% CI of the center point mfERG had a postoperative VA more than 0.5.Conclusions. The amplitude of central point mfERG in cataract patients was the most relevant parameter to the preoperative VA compared with PVEP and ERG. The 95% CI of the amplitude of central point mfERG for each level of VA could help to evaluate preoperative macular function which is used to predict the outcome of cataract surgery.

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