scholarly journals Electrophysiological Monitoring of Focal and Entire Retinal Function during Treatment with Intravitreal Methotrexate for Intraocular Lymphoma

2021 ◽  
pp. 277-282
Author(s):  
Takashi Matsushima ◽  
Yuji Yoshikawa ◽  
Airi Shimura ◽  
Ayana Yajima ◽  
Yui Ojima ◽  
...  
Keyword(s):  
Multifocal Electroretinogram ◽  
Malignant Lesion ◽  
Central Area ◽  
Interleukin 10 ◽  
High Ratio ◽  
Retinal Function ◽  
Intraocular Lymphoma ◽  
Blurred Vision ◽  
Macular Function ◽  
Skin Electrodes

We describe the electroretinographic findings of a case of primary intraocular lymphoma (PIOL) wherein the patient received intravitreal injections of methotrexate (ivMTX). A 62-year-old man developed blurred vision and complained of decreased visual acuity (VA) in his right eye. Fundus examination showed vitreous opacity and multiple subretinal yellowish lesions. Optical coherence tomography (OCT) revealed subretinal and intraretinal infiltrations. The full-field electroretinogram (ffERG) showed subnormal combined rod-cone response and multifocal electroretinogram (mfERG) recorded using skin electrodes showed severe attenuation of the response compared with the other eye. Pars prana vitrectomy, phacoemulsification, and lens implantation were performed to remove the opacity, and vitreous biopsy revealed a high ratio of interleukin 10–6 (76.0). There was no systemic malignant lesion, and the patient was diagnosed with PIOL. Treatment with ivMTX (400 μg/0.1 mL) was started. One month later, the intraretinal infiltration had disappeared, and mfERG revealed recovery of the response density from the central area. Two months later, OCT showed recovery of the foveal ellipsoid and interdigitation zones, and VA recovered to 20/17; mfERG showed maintenance of macular function. However, the amplitude of a- and b-waves in the ffERG gradually decreased. Macular function recovered, but there was also a decrease in total retinal function. mfERG and ffERG recorded using skin electrodes were useful in monitoring macular and entire retinal function with repeated examinations and showed recovery and maintenance of macular function in a case of PIOL treated with ivMTX.

scholarly journals The Success of Cataract Surgery and the Preoperative Measurement of Retinal Function by Electrophysiological Techniques

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jing An ◽  
Lei Zhang ◽  
Yusheng Wang ◽  
Zuoming Zhang
Keyword(s):  
Cataract Surgery ◽  
Multifocal Electroretinogram ◽  
Retinal Function ◽  
Central Point ◽  
Control Group ◽  
Relevant Parameter ◽  
Macular Function ◽  
Control Subjects ◽  
Center Point ◽  
Cataract Patients

Purpose. To study the effect of different electrophysiological methods to evaluate retinal function prior to cataract surgery.Methods. Cataract patients who had no significant other eye disease were chosen. VA, pattern visual evoked potential (PVEP), electroretinogram (ERG), and multifocal electroretinogram (mfERG) responses were measured from 150 cataract patients and 20 control subjects.Results. When the preoperative VA was more than 0.3 in cataract patients, the amplitude of PVEP was not significantly different between cataract and control subjects. The amplitude of central point mfERG was significantly lower in cataract patients compared with control group from HM to 0.8 of preoperative VA. The 95% confidence intervals (CIs) of the amplitudes of center point mfERG were calculated for a range of preoperative VA values. Most of the patients within 95% CI of the center point mfERG had a postoperative VA more than 0.5.Conclusions. The amplitude of central point mfERG in cataract patients was the most relevant parameter to the preoperative VA compared with PVEP and ERG. The 95% CI of the amplitude of central point mfERG for each level of VA could help to evaluate preoperative macular function which is used to predict the outcome of cataract surgery.

scholarly journals Assessment of Macular Function by Multifocal Electroretinogram in Patients with Multiple Sclerosis Treated with Fingolimod

2021 ◽  
Author(s):  
Lucilla Barbano ◽  
Lucia Ziccardi ◽  
Doriana Landi ◽  
Carolina Gabri Nicoletti ◽  
Giorgia Mataluni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Multifocal Electroretinogram ◽  
Macular Function

scholarly journals Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Seyedeh Maryam Hosseini ◽  
Mojtaba Abrishami ◽  
Elham Barashki ◽  
Ghodsieh Zamani
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Retinal Hemorrhage ◽  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma ◽  
Blurred Vision ◽  
Barr Virus ◽  
Epstein Barr

Purpose. Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. Case Presentation. A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Polymerase chain reaction-based analysis of the vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite systemic chemotherapy. Conclusion. There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.

Retinal Function in Normal and Diabetic Eyes Mapped with the Slow Flash Multifocal Electroretinogram

2004 ◽  
Vol 45 (1) ◽  
pp. 296 ◽  
Author(s):  
Marcus A. Bearse ◽  
Ying Han ◽  
Marilyn E. Schneck ◽  
Anthony J. Adams
Keyword(s):  
Multifocal Electroretinogram ◽  
Retinal Function

scholarly journals Toll-Like Receptor 2 Agonist Pam3CSK4 Alleviates the Pathology of Leptospirosis in Hamster

2016 ◽  
Vol 84 (12) ◽  
pp. 3350-3357 ◽  
Author(s):  
Wenlong Zhang ◽  
Naisheng Zhang ◽  
Xufeng Xie ◽  
Jian Guo ◽  
Xuemin Jin ◽  
...  
Keyword(s):  
Tissue Injury ◽  
Interleukin 10 ◽  
Peritoneal Macrophages ◽  
High Ratio ◽  
Toll Like Receptor ◽  
Wild Type ◽  
Necrosis Factor Alpha ◽  
Content Type ◽  
Target Organs ◽  
Toll Like Receptor 2

Leptospirosis, caused by pathogenic spirochetes, is a zoonotic disease of global importance. The detailed pathogenesis of leptospirosis is still unclear, which limits the ideal treatment of leptospirosis. In this study, we analyzed the expression of Toll-like receptor 2 (TLR2) and TLR4 in target organs of both resistant mice and susceptible hamsters after Leptospira interrogans serovar Autumnalis infection. TLR2 but not TLR4 transcripts in mouse organs contrasted with delayed induction and overexpression in hamster organs. Coinjection of leptospires and the TLR2 agonist Pam3CSK4 into hamsters improved their survival rate, alleviated tissue injury, and decreased the abundance of leptospires in target organs. The production of interleukin-10 (IL-10) from tissues was enhanced in hamsters of the group coinjected with leptospires and Pam3CSK4 compared with the leptospira-injected group. Similarly, IL-10 levels in TLR2-deficient mice were lower than those in wild-type mice. A high ratio of IL-10/tumor necrosis factor alpha (TNF-α) levels was found in both infected wild-type mice and hamsters coinjected with leptospires and Pam3CSK4. Moreover, TLR2-dependent IL-10 expression was detected in peritoneal macrophages after leptospira infection. Our data demonstrate that coinjection of leptospires and Pam3CSK4 alleviates the pathology of leptospirosis in hamsters; this effect may result from the enhanced expression of TLR2-dependent IL-10.

scholarly journals Diagnostic dilemma of ocular lymphoma

2019 ◽  
Vol 12 (6) ◽  
pp. e229513
Author(s):  
Vasilios Batis ◽  
James Shuttleworth ◽  
Garry Shuttleworth ◽  
Gwyn Samuel Williams
Keyword(s):  
Anterior Chamber ◽  
B Cell Lymphoma ◽  
Intraocular Lymphoma ◽  
Blurred Vision ◽  
Diagnostic Dilemma ◽  
Atypical Symptoms ◽  
Tertiary Centre ◽  
Ocular Lymphoma ◽  
Topical Dorzolamide ◽  
Oncology Centre

We report a very unusual presentation of primary intraocular lymphoma masquerading as anterior uveitis with atypical symptoms. A 68-year-old man, initially presented with a 4-day history of painless, left blurred vision. Examination revealed 2 or more anterior chamber cells, mutton-fat keratic precipitates and posterior synechiae. Treatment was initiated, the eye settled, and the patient was discharged. He re-presented 7 months later with hypopyon, a hazy cornea, fibrin deposits and a narrowed anterior chamber angle. Over the coming weeks, it became apparent that the temporal iris was thickened, involving the angle, and his intraocular pressure increased despite topical dorzolamide. Following advice from a tertiary centre and referral to a regional ocular oncology centre, a transscleral biopsy was performed and suggested a ciliary body melanoma. Enucleation was advised and performed, with histological examination revealing features consistent with an ocular diffuse large B-cell lymphoma not involving the optic nerve, sclera or cornea. This is the first ever published report of a case of ocular lymphoma masquerading in this way.

Lateral spread of adaptation as measured with the multifocal electroretinogram

2001 ◽  
Vol 18 (5) ◽  
pp. 687-694
Author(s):  
WILLIAM SEIPLE ◽  
THASARAT S. VAJARANANT ◽  
DAVID R. PEPPERBERG ◽  
JANET P. SZLYK
Keyword(s):  
Modulation Depth ◽  
Scattered Light ◽  
Multifocal Electroretinogram ◽  
Central Area ◽  
Luminance Level ◽  
Lateral Spread ◽  
Implicit Time ◽  
Multifocal Electroretinograms ◽  
Series Of Experiments ◽  
Order Kernel

We examined whether lateral spread of adaptation can be observed in the electroretinogram in humans. Specifically, we tested whether the luminance level of a surrounding, nonmodulated annulus affects the multifocal electroretinogram (ERG) response of a modulated central area. Multifocal electroretinograms were recorded in response to an array of 37 unscaled hexagons subtending a retinal area of 38 deg × 35 deg. Responses were recorded in six control subjects. In the first series of experiments, only the center hexagon was modulated, while the surrounding 36 hexagons were held constant at either 0.45, 172, or 340 cd/m2. In a subsequent series of control experiments, modulation depth of the center hexagon was varied and the proximity of the surrounding hexagon systematically altered. For the center-modulated condition, response amplitude and implicit time for the first-order kernel response significantly decreased as a function of increasing surround luminance. Control experiments demonstrated that the effect of the surround illumination was not due to scattered light but was influenced by the proximity of the surrounding annulus. These results demonstrate that lateral adaptation influences can be measured using the multifocal ERG.

scholarly journals Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Jiang Huang ◽  
Yi Li ◽  
Jianjiang Xiao ◽  
Qin Zhang ◽  
Guoxu Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multifocal Electroretinogram ◽  
Retinal Function ◽  
Spectral Domain ◽  
Implicit Time ◽  
Diagnostic Efficacy ◽  
Macular Volume ◽  
Amplitude Density ◽  
Sd Oct

Background. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations. Method. Fifty-three PD patients and forty-one healthy controls were enrolled. Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT. Results. The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions. The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD. The AUC of a single parameter of either retinal function or structure was low. Both of them were higher in diagnostic value to discriminate PD patients. Conclusion. The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD. It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD.

scholarly journals Evaluation of Macular Function after Vitrectomy in Diabetic Macular Edema

2021 ◽  
Vol 5 (1) ◽  
pp. 18-26
Author(s):  
Mona Abdelkader ◽  
◽  
Mohamed Mamdouh ◽  
Ayman Fawzy
Keyword(s):  
Visual Acuity ◽  
Retinal Thickness ◽  
Multifocal Electroretinogram ◽  
Diabetic Macular Oedema ◽  
Implicit Time ◽  
Diabetic Patients ◽  
Functional Evaluation ◽  
Macular Function ◽  
Full Field ◽  
Before And After

Purpose: To document the effects of successful vitrectomy on retinal function and anatomy in diabetic patients. Methods: Three-port pars plana vitrectomy with detachment of posterior vitrous face was performed in 30 eyes of 25 patients with diabetic macular oedema DME (11 male, 14 Female).For each patients, visual acuity (VA) examination, measurement of retinal thickness using optical coherence tomography (OCT), full field electro-retinogram (ERG) and multifocal eletroretinogram (MF-ERG) were performed before and 1week,1month and 3months after vitrectomy. Results: Mean postoperative visual acuity was significantly improved (P<0.05); mean retinal thickness was significantly (P=0.001 ) decreased after 3monthes of surgery (from 450±150 into 220±50 micron ) .b-wave amplitudes of all cone and rod responses of ERG were significantly decreased in all vitrectomized eyes after 1 week. At one month, rod response was still unimproved but improved after 3months. Reduction in foveal Function as well as in para-foveal areas detected in the MF-ERG within 1st month. Then, mean P1 wave amplitude of MF-ERG of central ring increased and mean P1 wave implicit time decreased. These changes of MF-ERG parameters observed 3 months after vitrectomy. Conclusion: Multifocal electroretinogram can be useful to provide objective criteria for functional evaluation before and after vitrectomy in diabetic oedema.

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