scholarly journals Age-Related Impairment in Choroidal Blood Flow Compensation for Arterial Blood Pressure Fluctuation in Pigeons

2011 ◽  
Vol 52 (10) ◽  
pp. 7238 ◽  
Author(s):  
Anton Reiner ◽  
Nobel Del Mar ◽  
Yuri Zagvazdin ◽  
Chunyan Li ◽  
Malinda E. C. Fitzgerald
1994 ◽  
Vol 267 (3) ◽  
pp. R687-R694 ◽  
Author(s):  
I. Lartaud ◽  
T. Makki ◽  
L. Bray-des-Boscs ◽  
N. Niederhoffer ◽  
J. Atkinson ◽  
...  

Age-related changes in systemic arterial blood pressure, basal cerebral blood flow (CBF), and CBF regulatory capacity were investigated in awake 6-, 12-, 24-, and 30-mo-old male Wistar (WAG/Rij) rats, one-half of which received the angiotensin I-converting enzyme inhibitor (ACEI) perindopril from 6 mo onward. There was no age-dependent change in mean arterial blood pressure, basal CBF, or cerebrovascular reactivity to hypercapnia, but the lower limit of CBF autoregulation rose from 70 mmHg at 6 and 12 mo to 90 mmHg in 24- and 30-mo-old animals. ACEI lowered mean arterial blood pressure but had no effect on basal CBF or on cerebrovascular reactivity to hypercapnia. ACEI shifted the lower limit of CBF autoregulation to a 20-mmHg-lower level in 12- and 24-mo animals but not in rats treated for 2 yr, i.e., from the ages of 6 to 30 mo. In conclusion, the main age-related change in CBF regulation was an increase in the lower limit of CBF autoregulation to a higher blood pressure level. Treatment with ACEI partially restored the lower limit of CBF autoregulation.


Eye ◽  
2003 ◽  
Vol 17 (1) ◽  
pp. 84-88 ◽  
Author(s):  
K Polak ◽  
E Polska ◽  
A Luksch ◽  
G Dorner ◽  
G Fuchsjäger-Mayrl ◽  
...  

2007 ◽  
Vol 48 (8) ◽  
pp. 3768 ◽  
Author(s):  
Elzbieta Polska ◽  
Christian Simader ◽  
Gu¨nter Weigert ◽  
Arno Doelemeyer ◽  
Julia Kolodjaschna ◽  
...  

2007 ◽  
Vol 104 (4) ◽  
pp. 853-856 ◽  
Author(s):  
Yoshihiro Fujiwara ◽  
Hiroshi Ito ◽  
Yusuke Asakura ◽  
Yuko Sato ◽  
Kimitoshi Nishiwaki ◽  
...  

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