Lamina Cribrosa Depth in Healthy Eyes

2014 ◽  
Vol 55 (3) ◽  
pp. 1241 ◽  
Author(s):  
Je Hyun Seo ◽  
Tae-Woo Kim ◽  
Robert N. Weinreb
Keyword(s):  
Lamina Cribrosa ◽  
Healthy Eyes

scholarly journals Anterior Displacement of Lamina Cribrosa during Valsalva Maneuver in Young Healthy Eyes

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159663 ◽  
Author(s):  
Yong Woo Kim ◽  
Michael J. A. Girard ◽  
Jean Martial Mari ◽  
Jin Wook Jeoung
Keyword(s):  
Valsalva Maneuver ◽  
Lamina Cribrosa ◽  
Anterior Displacement ◽  
Healthy Eyes

Relationship between lamina cribrosa curvature and the microvasculature in treatment-naïve eyes

2019 ◽  
Vol 104 (3) ◽  
pp. 398-403
Author(s):  
Ji-Ah Kim ◽  
Tae-Woo Kim ◽  
Eun Ji Lee ◽  
Michael J A Girard ◽  
Jean Martial Mari
Keyword(s):  
Visual Field ◽  
Mechanical Strain ◽  
Normal Tension Glaucoma ◽  
Lamina Cribrosa ◽  
Retinal Nerve Fibre Layer ◽  
Mean Deviation ◽  
Rnfl Thickness ◽  
Curvature Index ◽  
Treatment Naïve ◽  
Healthy Eyes

Background/AimsTo investigate the relationship between the lamina cribrosa (LC) curvature and the microvasculature within the LC in treatment-naïve eyes with normal-tension glaucoma (NTG) and in healthy eyes.MethodsForty-one eyes with treatment-naïve NTG and 41 age and sex-matched healthy control eyes were included. The optic nerve head (ONH) area was scanned using spectral-domain optical coherence tomography (OCT) to examine the LC curvature quantified as the LC curvature index (LCCI). OCT angiography of the ONH area was performed to determine the LC vessel density (LCVD) in the en face images obtained from the layer segmented at the level of the LC. The LCVD was calculated as the percentage area occupied by vessels within the measured region.ResultsThe LCCI was larger (9.53±1.33 vs 6.55±1.02, p<0.001) and LCVD was smaller (28.0%±6.1% vs 35.2±6.3%, p<0.001) in NTG eyes than in healthy eyes. There were overall significant associations of a smaller retinal nerve fibre layer (RNFL) thickness (p<0.001), a smaller visual field mean deviation (MD) (p=0.003) and a larger LCCI (p≤0.004) with a smaller LCVD. In NTG group, the LCVD was positively associated with the RNFL thickness (p=0.012) and visual field MD (p=0.023), and negatively associated with the axial length (p≤0.013) and LCCI (p≤0.007). In healthy group, a smaller RNFL thickness (p=0.023) was associated with a smaller LCVD.ConclusionA larger LCCI was significantly associated with a smaller LCVD in treatment-naïve NTG eyes but not in healthy eyes, indicating that mechanical strain potentially influences the perfusion within the LC in eyes with NTG.

scholarly journals Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Elizabeth M McElnea ◽  
Emily Hughes ◽  
Aloysius McGoldrick ◽  
Amanda McCann ◽  
Barry Quill ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Lipofuscin Accumulation

scholarly journals Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ying-Yi Chen ◽  
Yi-Chen Sun ◽  
Chia-Ying Tsai ◽  
Hsiao-Sang Chu ◽  
Jo-Hsuan Wu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ocular Surface ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Slit Lamp ◽  
Ocular Rosacea ◽  
Unilateral Disease ◽  
Healthy Eyes ◽  
Slit Lamp Biomicroscopy ◽  
Sd Oct

AbstractSpectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Eighteen eyes of 10 patients with advancing wavelike epitheliopathy (AWE) and 15 eyes of 9 patients with phlyctenular keratitis/ocular rosacea were recruited. SD-OCT could detect abnormal changes in the POV in 100% of the lesion sites. In presumed-healthy areas of the diseased eyes diagnosed by slit-lamp biomicroscopy, SD-OCT detected abnormal changes in the POV in 100% of the eyes in both groups. In patients with unilateral disease, abnormal changes in the POV were detected by SD-OCT in 50% and 100% of presumed-healthy eyes diagnosed by slit-lamp biomicroscopy in the AWE group and phlyctenular keratitis/ocular rosacea group, respectively. SD-OCT is powerful in detecting POV changes in ocular surface disorders and can provide useful information that cannot be provided by slit-lamp biomicroscopy.

scholarly journals Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

2011 ◽  
Vol 52 (10) ◽  
pp. 7109 ◽  
Author(s):  
Hongli Yang ◽  
Galen Williams ◽  
J. Crawford Downs ◽  
Ian A. Sigal ◽  
Michael D. Roberts ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Experimental Glaucoma ◽  
Outward Migration

scholarly journals Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects

Ophthalmology ◽  
2017 ◽  
Vol 124 (11) ◽  
pp. 1600-1611 ◽  
Author(s):  
Yu Sawada ◽  
Makoto Araie ◽  
Makoto Ishikawa ◽  
Takeshi Yoshitomi
Keyword(s):  
Visual Field ◽  
Lamina Cribrosa ◽  
Visual Field Defects ◽  
Field Defects
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