Normal Value Ranges for Central Retinal Thickness Asymmetry in Healthy Caucasian Adults Measured by SPECTRALIS SD-OCT Posterior Pole Asymmetry Analysis

Purpose: The aim of this study is to evaluate the variability of central retinal thickness asymmetry in healthy Caucasian adults with the posterior pole asymmetry analysis to serve as a reference. Methods: In total, 404 eyes of 202 subjects who aged between 18 and 80 years, who had no ocular pathology, were included in this cross-sectional observational study. Retinal thickness maps with posterior pole asymmetry analysis mode were taken with the optical coherence tomography (SPECTRALIS SD-OCT; Heidelberg Engineering). Superior and inferior hemifields were divided into five zones resembling to the strategy in Glaucoma Hemifield Test. Mean retinal thickness in each of the five zones was compared with the thickness of the corresponding zone in each eye (paired-samples t-test), and differences in retinal thickness (DRT1–5) and ganglion cell layer thickness between reciprocal locations were measured. Differences in retinal thickness values of two eyes of each subject were also compared (independent-samples t-test). Results: The intra-eye asymmetry was statistically significant in zones 4 and 5. The highest mean intraocular differences in retinal thickness were 5.8 µm (zone 5) in all eyes, 5.8 µm (zone 5) in the right eyes, and 5.9 µm (zones 4 and 5) in the left eyes. The only statistically significant interocular local differences in retinal thickness asymmetries were found in zone 3. The intraocular asymmetry in retinal thickness was found to be the lowest in zone 1. The differences of ganglion cell layer thickness (GCLTs) were not statistically significant. Conclusion: There were statistically significant physiological inter-eye asymmetry in zone 3 and intra-eye asymmetries in zones 4 and 5. These measurements must be considered during screening for glaucoma with posterior pole asymmetry analysis in the Caucasian population.

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Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of glaucoma patients

The Kaohsiung Journal of Medical Sciences ◽

10.1016/j.kjms.2015.06.001 ◽

2015 ◽

Vol 31 (8) ◽

pp. 420-425 ◽

Cited By ~ 5

Author(s):

Gökhan Pekel ◽

Semra Acer ◽

Ramazan Yağcı ◽

Hüseyin Kaya ◽

Fatih Özbakış ◽

...

Keyword(s):

Retinal Thickness ◽

Posterior Pole ◽

Asymmetry Analysis ◽

Pole Asymmetry ◽

Thickness Measurements

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Sub-Threshold Micro Pulse Laser (810NM): Treatment for Chronic Central Serous Retinopathy

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v37i2.1152 ◽

2021 ◽

Vol 37 (2) ◽

Author(s):

Mariam Shamim Kashif ◽

Najia Uzair ◽

Lubna Feroz ◽

Asaad Mehmood

Keyword(s):

Retinal Thickness ◽

Case Series ◽

Central Retinal Thickness ◽

Central Serous Retinopathy ◽

Invasive Treatment ◽

Micropulse Laser ◽

Corrected Visual Acuity ◽

Best Corrected Visual Acuity ◽

Sd Oct

Purpose: To find the effectiveness of sub-threshold (810nm) micropulse diode laser treatment (SMT) in chronic central serous retinopathy (CSR). Study Design: Interventional case series. Place and Duration of Study: Layton Rahmatulla benevolent trust eye hospital, from April 2019 to July 2020. Methods: The patients of chronic CSR (≥ 6 months) participated in the study. We used Spectral Domain Optical coherence tomography (SD-OCT) to record baseline central retinal thickness (CT). Best corrected visual acuity (BCVA) was recorded with Snellen’s chart and converted to Log MAR for statistical analysis. All patients underwent treatment with sub-threshold laser (810nm) in micropulse mode with 5% duty cycle (DC). Results: Twenty five eyes with chronic CSR were enrolled in the study. The patients were treated with laser and final assessment was made at 6 months. Mean BCVA at presentation was 0.46 Log MAR ± 0.12 and a mean baseline CT of 362.2 μm ± 32.6µm. At final follow-up there was a mean decrease in CT of 97.2 μm ± 21.8 from the baseline. After treatment mean BCVA was 0.33 Log MAR ± 0.12 and mean CT was 266 μm ± 20.9. Nineteen out of twenty-five eyes (76%) achieved a gain of vision between 1 to 3 lines and gain of 3 lines was achieved in 8% of cases. At the final follow-up there was incomplete resolution of sub retinal fluid in 4 eyes (16%) with no improvement in BCVA. Conclusion: SMT (810 nm) is an effective and minimally invasive treatment modality for chronic CSR. Key Words: Sub-Threshold micropulse laser, Central serous retinopathy, Central retinal thickness, sub retinal fluid.

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Association between central retinal thickness and low luminance visual acuity in early age-related macular degeneration

European Journal of Ophthalmology ◽

10.1177/1120672120968740 ◽

2020 ◽

pp. 112067212096874

Author(s):

María Cinta Puell ◽

Francisco Javier Hurtado-Ceña ◽

María Jesús Pérez-Carrasco ◽

Inés Contreras

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Retinal Thickness ◽

Central Area ◽

Age Related Macular Degeneration ◽

Central Retinal Thickness ◽

Cross Sectional ◽

Age Related ◽

Low Luminance ◽

Sd Oct

Purpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p < 0.01). CRT and mesopic pupil size were independent predictors of mesopic VA ( p = 0.001). CRT emerged as the only independent predictor of LLD ( p = 0.004). Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD.

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