scholarly journals Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression

2019 ◽  
Vol 60 (7) ◽  
pp. 2650 ◽  
Author(s):  
Naoki Kiyota ◽  
Yukihiro Shiga ◽  
Masayuki Yasuda ◽  
Naoko Aizawa ◽  
Kazuko Omodaka ◽  
...  



2010 ◽  
Vol 26 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Yukiko Yoshida ◽  
Tetsuya Sugiyama ◽  
Keita Utsunomiya ◽  
Yasuharu Ogura ◽  
Tsunehiko Ikeda


1999 ◽  
Vol 77 (S229) ◽  
pp. 40-41
Author(s):  
L. Mastropasqua ◽  
M. Ciancaglini ◽  
P. Carpineto ◽  
G. Falconio ◽  
E. Zuppardi ◽  
...  


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hae-Young Lopilly Park ◽  
Yong Chan Kim ◽  
Younhea Jung ◽  
Chan Kee Park


2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Chan Hee Moon ◽  
Jungwoo Han ◽  
Young-Hoon Ohn ◽  
Tae Kwann Park

Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma.Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured from the baseline to the peak of the second positive deflection of the induced component. The ONHC amplitude was normalized by dividing ONHC amplitude by the average of seven largest ONHC amplitudes. The ONHC amplitude ratio map and ONHC deficiency map were constructed. The local relationship between the ONHC measurements and visual field defects was evaluated by calculating the overlap between the ONHC deficiency maps and visual field defect plots.Results.The mean ONHC amplitude measurements of patients with glaucoma (6.01±1.91 nV/deg2) were significantly lower than those of the normal controls (10.29±0.94 nV/deg2) (P<0.001). The average overlap between the ONHC deficiency map and visual field defect plot was 71.4%. The highest overlap (75.0%) was between the ONHC ratios less than 0.5 and the total deviations less than 5%.Conclusions.The ONHC amplitude was reduced in patients with glaucoma compared to that in normal controls. Loss of the ONHC amplitude from the global-flash mfERG showed a high local agreement with visual field defects in patients with glaucoma.



2020 ◽  
Vol 98 (6) ◽  
Author(s):  
Naoki Kiyota ◽  
Yukihiro Shiga ◽  
Masayuki Yasuda ◽  
Naoko Aizawa ◽  
Kazuko Omodaka ◽  
...  


Author(s):  
David Kuerten ◽  
Matthias Fuest ◽  
Peter Walter ◽  
Babac Mazinani ◽  
Niklas Plange

Abstract Purpose To investigate the relationship of ocular blood flow (via arteriovenous passage time, AVP) and contrast sensitivity (CS) in healthy as well as normal tension glaucoma (NTG) subjects. Design Mono-center comparative prospective trial Methods Twenty-five NTG patients without medication and 25 healthy test participants were recruited. AVP as a measure of retinal blood flow was recorded via fluorescein angiography after CS measurement using digital image analysis. Association of AVP and CS at 4 spatial frequencies (3, 6, 12, and 18 cycles per degree, cpd) was explored with correlation analysis. Results Significant differences regarding AVP, visual field defect, intraocular pressure, and CS measurement were recorded in-between the control group and NTG patients. In NTG patients, AVP was significantly correlated to CS at all investigated cpd (3 cpd: r =  − 0.432, p< 0.03; 6 cpd: r =  − 0.629, p< 0.0005; 12 cpd: r =  − 0.535, p< 0.005; and 18 cpd: r =  − 0.58, p< 0.001), whereas no significant correlations were found in the control group. Visual acuity was significantly correlated to CS at 6, 12, and 18 cpd in NTG patients (r =  − 0.68, p< 0.002; r =  − 0.54, p< .02, and r =  − 0.88, p< 0.0001 respectively), however not in healthy control patients. Age, visual field defect MD, and PSD were not significantly correlated to CS in in the NTG group. MD and PSD were significantly correlated to CS at 3 cpd in healthy eyes (r = 0.55, p< 0.02; r =  − 0.47, p< 0.03). Conclusion Retinal blood flow alterations show a relationship with contrast sensitivity loss in NTG patients. This might reflect a disease-related link between retinal blood flow and visual function. This association was not recorded in healthy volunteers.



2018 ◽  
Vol 190 ◽  
pp. 34-49 ◽  
Author(s):  
Yu Sawada ◽  
Makoto Araie ◽  
Hitomi Kasuga ◽  
Makoto Ishikawa ◽  
Toyoto Iwata ◽  
...  


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