scholarly journals Diabetic Macular Ischemia: Influence of Optical Coherence Tomography Angiography Parameters on Changes in Functional Outcomes Over One Year

2021 ◽  
Vol 62 (1) ◽  
pp. 9
Author(s):  
Andrew S. H. Tsai ◽  
Janice Marie Jordan-Yu ◽  
Alfred T. L. Gan ◽  
Kelvin Y. C. Teo ◽  
Gavin S. W. Tan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Functional Outcomes ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
One Year ◽  
Macular Ischemia

scholarly journals Retinal Sensitivity Loss Correlates with Deep Capillary Plexus Impairment in Diabetic Macular Ischemia

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Fabio Scarinci ◽  
Monica Varano ◽  
Mariacristina Parravano
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Diabetic Patients ◽  
Retinal Sensitivity ◽  
Optical Coherence ◽  
Type 2 Diabetic Patients ◽  
Sensitivity Loss ◽  
Capillary Plexus ◽  
Macular Ischemia ◽  
Sd Oct

Purpose. To assess retinal sensitivity and retinal morphologic changes of capillary nonperfused areas in diabetic macular ischemia. Methods. Observational cross-sectional study. Patients were examined at IRCCS—Bietti Foundation, Rome, Italy. Fourteen consecutive diabetic eyes showing outer retinal changes on spectral domain optical coherence tomography B-scan were included. Ten eyes of ten diabetic patients with normal outer retinal structure on SD-OCT were included as controls. All eyes underwent optical coherence tomography angiography (OCTA) and MP1 microperimetry. To explore the outer retina findings and localized areas of capillary nonperfusion at the superficial and deep capillary plexus, we used the Spectralis HRA + OCTA (Heidelberg Engineering, Heidelberg, Germany). The B-scans as either normal or having outer retinal disruption and the enface images at the level of the superficial and/or deep capillary plexus were evaluated to identify areas of capillary nonperfusion. Results. Fourteen eyes of 12 consecutive type 2 diabetic patients with outer retinal disruption on SD-OCT showed that areas of capillary nonperfusion of the deep capillary plexus were colocalized to areas of reduced retinal sensitivity. Conclusions. On optical coherence tomography angiography, areas of capillary nonperfusion of deep capillary plexus due to macular ischemia are associated with photoreceptor structural abnormalities and retinal sensitivity loss on microperimetry. This highlights that the health status of deep capillary plexus and not only the choroid is important to the oxygen requirements of the photoreceptors in patients with diabetic macular ischemia. Also, the anatomical and functional consequences of these findings might help to explore the efficacy of new therapy into the macular area in clinical practice.

Quantification of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography and Its Relationship with Visual Acuity

Ophthalmology ◽  
2017 ◽  
Vol 124 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Wasim A. Samara ◽  
Abtin Shahlaee ◽  
Murtaza K. Adam ◽  
M. Ali Khan ◽  
Allen Chiang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Macular Ischemia

scholarly journals Quantification of diabetic macular ischemia: Assessing agreement and reproducibility between Optical coherence tomography angiography and Fluorescein angiography

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Jeniffer Trenado ◽  
Sergio Rojas juárez
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Fluorescein Angiography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
Intraclass Correlation ◽  
Optical Coherence ◽  
Study Protocols ◽  
Level Of Agreement ◽  
Macular Ischemia

Introduction: The purpose was to assess the level of agreement and reproducibility between fluorescein angiography (FA) and optical coherence tomography angiography (OCTA), throughout the evaluation of the foveal avascular zone (FAZ) to diagnose diabetic macular ischemia (DMI). Methods: In this ambispective, observational, cross-sectional research, 41 patients underwent traditional FA and OCTA to obtain the level of agreement and reproducibility between them, using an intraclass correlation coefficient (ICC) in mixed models. Two raters independently graded the area of the FAZ using the ImageJ software and the Early Treatment Diabetic Retinopathy Study protocols. Spearman and rank-biserial correlational analysis were used to calculate the strength of linear relationship between the area of the retinal vessels, the thickness of subfoveal retinal and choroid layers, the presence of neovascularization, and the visual acuity. A classification, based on the radius of the FAZ, was proposed and used to categorize the severity of DMI into five different grades. Result: From 52 evaluated eyes, the level of agreement between the OCTA and FA among the raters had an ICC of 0.99 and 0.907 (p<.001), respectively. Furthermore, the reproducibility analysis had an ICC of 0.85 (p<.001). In the correlation analysis, the enlargement of the FAZ was associated with a decrease in the outer retinal layers (r=-0.458, p<0.001), the photoreceptor layer (r=-0.32, p=0.021), their outer segments (r=-0.32, p=0.021) and the subfoveal choroidal thickness (r=-0.483, p<0.001). A reduction of the vascular area was observed in higher grades of diabetic retinopathy (r= -0.395, p=0.38). Additionally, meager choroidal thickness was found in grater grades of DMI (r=-0.461, p=0.014). Conclusion: Compelling evidence of a high level of agreement and reproducibility between OCTA and FA was obtained to diagnose diabetic macular ischemia. Moreover, it is suggested that the increase in macular ischemia leads to the thinning of the photoreceptor, outer retinal and choroid layers.

Correlation between visual acuity and diabetic macular ischemia using optical coherence tomography angiography

2019 ◽  
Vol 6 (2) ◽  
pp. 33
Author(s):  
LydiaMaged Louis ◽  
AlaaEldin Fayed ◽  
MohamedSalah Helal ◽  
AhmedMohammed Habib ◽  
MohammedHanafy Hashem ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Macular Ischemia

scholarly journals Diabetic Macular Ischemia Diagnosis: Comparison between Optical Coherence Tomography Angiography and Fluorescein Angiography

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jose Mauricio Botto de Barros Garcia ◽  
Talita Toledo Lima ◽  
Ricardo Noguera Louzada ◽  
Alessandra Thome Rassi ◽  
David Leonardo Cruvinel Isaac ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Rank Test ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Macular Ischemia

Purpose. To compare fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia (DMI).Methods. The Wilcoxon signed-rank test was used to compare area measurements andpvalues of <0.05 were considered statistically significant. FA and OCTA images were independently graded by 2 observers that reached agreement regarding quantitative DMI according established protocols. The ischemic area was divided into “large” macular ischemia (superior to 0.32 mm2) and “small” (inferior to 0.32 mm2) groups. Quantitative analyses of the FAZ were performed using custom software.Results. Thirty-four eyes from 34 diabetic patients were enrolled. Subjects with DMI presented a mean area on FA and OCTA of 0.68 ± 0.53 mm2and 0.58 ± 0.35 mm2, respectively (p=0.1374). Patients without DMI presented a mean area on FA and OCTA of 0.19 ± 0.67 mm2and 0.20 ± 0.79 mm2, respectively (p=0.9594). The ICC for the FAZ measurements between the 2 observers on FA and OCTA was 0.96 and 0.92, respectively.Conclusion. OCTA represents a novel technique for the diagnosis of DMI and it may become an alternative to FA for this purpose.

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