scholarly journals Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome?

2016 ◽  
Vol 127 (1) ◽  
pp. 98-99 ◽  
Author(s):  
Joseph Polex-Wolf ◽  
Giles S.H. Yeo ◽  
Stephen O’Rahilly
2021 ◽  
Vol 51 (1) ◽  
pp. 22-30
Author(s):  
Daniel P. McCarthy

Christ’s bones are missing at the Holy Sepulchre; St Peter’s bones remain in his basilica; Hagia Sophia was not built on bones. The absence, presence, or lack of bones effects different emphases on memory (anamnesis) and fulfillment (eschatology). In Jerusalem we witness our future glory (eschatology) already revealed in our history (anamnesis); in Rome we recall (anamnesis) the sacrifice of martyrs whose bones remain until the general resurrection (eschatology), even while we venerate the saints in light; at Hagia Sophia liturgy itself, rather than bones, provides the context for remembering the whole Christ in the power of the Spirit. Celebrating liturgy over the bones of martyrs in Rome, while venerating their sacrifice, may have accentuated the sacrificial character of the eucharistic liturgy in the Christian west, whereas in the Christian east the eschatological glory already revealed in our history and in liturgy may have shaped the eschatological character of liturgy.


2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
George Lazarides ◽  
Mansoor Ur Rehman ◽  
Qaisar Shafi

Abstract We discuss proton decay in a recently proposed model of supersymmetric hybrid inflation based on the gauge symmetry SU(4)c× SU(2)L× SU(2)R. A U(1) R symmetry plays an essential role in realizing inflation as well as in eliminating some undesirable baryon number violating operators. Proton decay is primarily mediated by a variety of color triplets from chiral superfields, and it lies in the observable range for a range of intermediate scale masses for the triplets. The decay modes include p → e+(μ+) + π0, $$ p\to \overline{\nu}+{\pi}^{+} $$ p → ν ¯ + π + , p → K0 + e+(μ+), and $$ p\to {K}^{+}+\overline{\nu} $$ p → K + + ν ¯ , with a lifetime estimate of order 1034–1036 yrs and accessible at Hyper-Kamiokande and future upgrades. The unification at the Grand Unified Theory (GUT) scale MGUT (∼ 1016 GeV) of the Minimal Supersymmetric Standard Model (MSSM) gauge couplings is briefly discussed.


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