Symptom Outcome in Early-Onset Bipolar Disorder: Could Be Better, Could Be Worse

SummaryLithium is widely prescribed, but the timing of key effects remains uncertain. The timing of onset of its relapse prevention effects is clarified by placebo-controlled randomised trials (3 studies, n = 1120). Lithium reduced relapse into any mood episode over the first 2 weeks of treatment (hazard ratio 0.40, 95% CI 0.16–0.97). Fewer manic relapses were evident within the first 4 weeks, however, early effects on depressive relapse were not demonstrated. There is an early onset of lithium relapse prevention effects in bipolar disorder, particularly against manic relapse. Full effects against depressive relapse may develop over a longer period.Declaration of interestM.J.T. reports personal fees from Sunovion, Otsuka, Lundbeck, outside the submitted work.

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Early and Late Onset Bipolar Disorders in Older Adults

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.2179 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S211-S211

Author(s):

N. Smaoui ◽

L. Zouari ◽

N. Charfi ◽

M. Maâlej-Bouali ◽

N. Zouari ◽

...

Keyword(s):

Older Adults ◽

Bipolar Disorder ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Age At Onset ◽

Bipolar Disorders ◽

Medical Diagnoses ◽

The Mean ◽

Bipolar Patients

IntroductionAge of onset of illness may be useful in explaining the heterogeneity among older bipolar patients.ObjectiveTo examine the relationship of age of onset with clinical, demographic and behavioral variables, in older patients with bipolar disorder.MethodsThis was a cross-sectional, descriptive and analytical study, including 24 patients suffering from bipolar disorders, aged 65 years or more and followed-up in outpatient psychiatry unit at Hedi Chaker university hospital in Sfax in Tunisia. We used a standardized questionnaire including socio-demographic, behavioral and clinical data. Age of onset was split at age 40 years into early-onset (< 40 years; n = 12) and late-onset (≥ 40 years; n = 12) groups.ResultsThe mean age for the entire sample was 68.95 years. The mean age of onset was 39.95 years. The majority (60%) of patients were diagnosed with bipolar I. Few meaningful differences emerged between early-onset and late-onset groups, except that tobacco use was significantly higher in the late-onset group (66.6% vs. 16.6%; P = 0.027). No significant differences between the early-onset and late-onset groups were seen on demographic variables, family history and number of medical diagnoses or presence of psychotic features.ConclusionOur study found few meaningful behavioral differences between early versus late age at onset in older adults with bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Early-Onset Bipolar Disorder: Characteristics and Outcomes in the Clinic

Journal of Child and Adolescent Psychopharmacology ◽

10.1089/cap.2017.0058 ◽

2017 ◽

Vol 27 (10) ◽

pp. 875-883 ◽

Cited By ~ 8

Author(s):

Daniel F. Connor ◽

Julian D. Ford ◽

Geraldine S. Pearson ◽

Victoria L. Scranton ◽

Asha Dusad

Keyword(s):

Bipolar Disorder ◽

Early Onset

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Debate Editorial: Very early onset bipolar disorder - international differences in prevalence, practice or language?

Child and Adolescent Mental Health ◽

10.1111/camh.12315 ◽

2019 ◽

Vol 24 (1) ◽

pp. 86-87

Author(s):

Gabrielle A. Carlson ◽

Bernadka Dubicka

Keyword(s):

Bipolar Disorder ◽

Early Onset ◽

International Differences

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Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample

European Psychiatry ◽

10.1016/j.eurpsy.2010.09.013 ◽

2011 ◽

Vol 26 (3) ◽

pp. 141-143 ◽

Cited By ~ 11

Author(s):

A. Squassina ◽

M. Manchia ◽

M. Costa ◽

C. Chillotti ◽

R. Ardau ◽

...

Keyword(s):

Bipolar Disorder ◽

Association Study ◽

Early Onset ◽

Psychiatric Illness ◽

Age At Onset ◽

Drd2 Gene ◽

Genetic Complexity

AbstractBipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.

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