Borderline personality disorder (BPD) is a prevalent, debilitating syndrome. Patients with BPD heavily utilize mental health services and have historically had a poor prognosis. In the IPT adaptation for BPD, the therapist presents BPD to the patient as a poorly named syndrome that has a significant depressive component. The goals of IPT in this population are threefold: to link mood (including anger) to interpersonal situations, to find better ways of handling such situations, and to build better social supports and skills. When patient–therapist problems crop up, the therapist addresses them in a here-and-now, interpersonal fashion rather than making psychodynamic interpretations. Because patients with BPD are sensitive to abandonment, termination is discussed early and often. Research on the use of IPT in patients with BPD is tantalizing but fragmentary, in need of a larger and more definitive trial.