This chapter reviews common therapeutic issues and various questions asked by patients during IPT. Common therapeutic issues include deciding whether a patient’s main problem is a psychiatric illness or a personality disorder, dealing effectively with passive or intellectualizing patients, keeping to the agreed-on focus and time limit of treatment, and making therapeutic use of silence in session. Technical issues such as rating scales and recording sessions are discussed, and IPT was contrasted with other types of psychotherapy such as CBT. Common patient questions include how IPT works, therapist credentials, lateness to sessions, family members attending treatment sessions, the genetic and biological basis of depression, the use of alcohol and drugs, recurrence of depression, and suicide. Some problems that are more often seen in primary care settings are also covered, such as depression manifesting through physical symptoms and poor adherence to treatment.