scholarly journals Ferritin and iron studies in anaemia and chronic disease

2016 ◽  
Vol 54 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ying Y Peng ◽  
James Uprichard
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Deficiency Anaemia ◽  
Iron Homeostasis ◽  
Red Cells ◽  
Pivotal Role ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Common Causes

Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia and the anaemia of chronic disease are the two most common causes of anaemia worldwide;1 iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential not only for diagnosis but also in guiding management. This review will primarily focus on iron deficiency anaemia and anaemia of chronic disease; however, iron overload in anaemia will also be briefly discussed.

Haematology

2012 ◽  
pp. 451-464
Author(s):  
Lesley K Bowker ◽  
James D Price ◽  
Sarah C Smith
Keyword(s):  
Multiple Myeloma ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Older People ◽  
Myelodysplastic Syndrome ◽  
Iron Deficiency Anaemia ◽  
Macrocytic Anaemia ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Haematopoietic System

The ageing haematopoietic system 452 Investigating anaemia in older people 453 Iron deficiency anaemia: diagnosis 454 HOW TO . . . Investigate iron deficiency anaemia 455 Iron deficiency anaemia: treatment 456 Macrocytic anaemia 457 Anaemia of chronic disease 458 Paraproteinaemias 459 Multiple myeloma 460 Myelodysplasia and myelodysplastic syndrome ...

scholarly journals The Value of Soluble Transferrin Receptor and Soluble Transferrin Receptor-ferritin Index in Discriminating Iron Deficiency Anaemia from Anaemia of Chronic Disease in Patients With Rheumatoid Arthritis

2019 ◽  
Vol 13 (1) ◽  
pp. 9-14
Author(s):  
Haithem A. Al-Rubaie ◽  
Israa M. Al-Bayaa ◽  
Yassmin A. Al-Amiri
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Soluble Form ◽  
Soluble Transferrin Receptor ◽  
Deficiency Anaemia ◽  
Inflammatory Status ◽  
Anaemia Of Chronic Disease

Background:Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA) where anaemia of chronic disease (ACD) and iron deficiency anaemia (IDA) are the two most frequent types. The distinction between these two types of anaemia has always been challenging requiring sophisticated techniques. Serum transferrin receptor (sTfR) a truncated soluble form of the transferrin receptor is one of the parameters that is influenced by the Iron content and supply to the erythrons and is not affected by inflammatory status and therefore the use of the sTfR/log ferritin (sTfR-F) index can be a reliable indicator of functional iron deficiency.Aim of the study:This study aims to evaluate the usefulness of sTfR and sTfR-F index in discriminating the most common types of anaemia in patients with RA.Patients and methods:The study included 50 patients with RA and 30 healthy subjects as a control group. Complete blood picture, C-reactive protein, serum Iron, unsaturated iron binding capacity, sTfR and serum ferritin were tested.Results and Conclusion:anaemia was present in 34/50 patients; 19 patients had ACD, 9 had ACD/IDA and only 6 patients had IDA. Both the sTfR and the sTfR-F index showed a significant difference between anaemia groups (P values = 0.037 and 0.001, respectively). sTfR-F index has shown to be a very useful parameter that can discriminate efficiently between IDA and ACD and between ACD and ACD/IDA in patients with RA.

scholarly journals Suitability of soluble transferrin receptor for the clinical diagnosis of different types of anaemia in children

2002 ◽  
Vol 8 (2-3) ◽  
pp. 298-307
Author(s):  
L. Ragab ◽  
H. A. Ibrahim ◽  
A. S. Eid ◽  
T. Kotb ◽  
M. F. Konsowa
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Iron Status ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Egyptian Children ◽  
Different Types ◽  
Patient Groups

We evaluated the ability of serum transferrin receptor [sTFR] to identify different types of anaemia in children. Thus 150 Egyptian children suffering from anaemia [iron deficiency anaemia, anaemia of chronic disease and beta-thalassaemia] were enrolled, together with 50 controls. There was a significant increase in the mean levels of sTFR in the groups with iron deficiency anaemia and thalassaemia, and a significant decrease in mean sTFR levels in the group with anaemia of chronic disease. Serum ferritin levels were significantly higher in all patient groups except the group with iron deficiency anaemia. There were also significant correlations between the sTFR and sTFR/log ferritin ratio [sTFR-F index] and different indices of iron status and of erythropoiesis. The sTFR-F index could be used as a diagnostic or screening tool for iron deficiency anaemia, anaemia of chronic disease and thalassaemia.

Haematology

2018 ◽  
Author(s):  
Lesley K. Bowker ◽  
James D. Price ◽  
Ku Shah ◽  
Sarah C. Smith
Keyword(s):  
Multiple Myeloma ◽  
Chronic Disease ◽  
Iron Deficiency ◽  
Myelodysplastic Syndrome ◽  
Iron Deficiency Anaemia ◽  
Lymphocytic Leukaemia ◽  
Macrocytic Anaemia ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Haematopoietic System

This chapter provides information on the ageing haematopoietic system, investigating anaemia in older people, diagnosis of iron deficiency anaemia, treatment of iron deficiency anaemia, macrocytic anaemia, anaemia of chronic disease, paraproteinaemias, multiple myeloma, myelodysplasia and myelodysplastic syndrome, and chronic lymphocytic leukaemia.

scholarly journals ETIOLOGICAL PROFILE OF 50 CASES 0F ANAEMIA IN CKD

2020 ◽  
pp. 1-2
Author(s):  
Yalavarthi Hema Choudary ◽  
E. Karthik ◽  
Ch. Sudhakar
Keyword(s):  
Chronic Disease ◽  
Kidney Disease ◽  
Iron Deficiency ◽  
Clinical Examination ◽  
Iron Deficiency Anaemia ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anaemia ◽  
Anaemia Of Chronic Disease ◽  
B12 Deficiency ◽  
Erythropoietin Deficiency

Background and objectives: Anaemia is a common and significant complication of chronic kidney disease (CKD). When present it may cause symptoms such as fatigue and shortness of breath. It is associated with reduced quality of life and increased cardiovascular disease, hospitalizations, cognitive impairment and mortality. As kidney disease progresses, anaemia increases in prevalence affecting nearly all patients with stage V CKD. In patients with CKD, anaemia is defined as the situation in which the concentration of haemoglobin (Hb) in the blood is below 2 times the SD of the mean Hb of the general population. As the pathogenesis of anaemia in CKD is mutlifactorial, this study is intended to know various etiological factors responsible for anaemia in CKD patients. Methods: 50 patients who met with inclusion criteria and exclusion criteria are subjected to detail clinical examination and investigations. Depending upon data obtained, results are evaluated and the percentage of various types of anaemia in CKD was calculated. Results: At the end of study, anaemia of chronic disease (60%) constitutes the commonest cause of anaemia in CKD, followed by iron deficiency anaemia (30%) and megaloblastic anaemia (10%) due to vitamin B12 deficiency. Conclusion: Among 50 cases of anaemia in CKD, anaemia of chronic disease due to erythropoietin deficiency was the most common cause followed by iron deficiency anaemia. Usually clinical examination and routine simple investigations will clinch the diagnosis in most of the cases.

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