Digoxin-Like Immunoreactivity in Early Infantile Death

1998 ◽  
Vol 38 (1) ◽  
pp. 52-56
Author(s):  
R T L Couper ◽  
J J E Aldis ◽  
R W Byard
Keyword(s):  
Sudden Infant Death ◽  
Adrenal Weight ◽  
Right Atrial ◽  
Sudden Infant ◽  
Meningococcal Sepsis ◽  
Post Mortem ◽  
Age At Death ◽  
Cardiac Pathology ◽  
Post Mortem Interval ◽  
Digoxin Radioimmunoassay

The aim of this study was to determine if the level of digoxin-like immunoreactivity in post-mortem sera obtained from infants differs according to the cause of death and if the level is related to age, post-mortem interval, cardiac pathology or adrenal weight. Twelve infants whose deaths were attributed to sudden infant death syndrome (SIDS), and 11 infants who died from other causes, had blood sampled between 3 to 53 hours post-mortem from their right atrial cavity. Digoxin-like immunoreactivity was measured, using a specific and sensitive digoxin radioimmunoassay, and was detected in 7 of the infants who died of SIDS and 7 of those who died from other causes. The highest levels were seen in two patients who died from meningococcal sepsis and haemorrhage, hyperpyrexia and encephalopathy syndrome, respectively. No correlation was detected between the digoxin-like immunoreactivity level, gender, age at death, post-mortem interval or cardiac pathology. Digoxin-like immunoreactivity levels correlated with adrenal weight. It is concluded that digoxin-like immunoreactivity is frequently found in infant sera, but levels are not specific to and are no higher in SIDS infants than infants dying of other conditions.

Sudden Infant Death Syndrome, Bedsharing, Parental Weight, and Age at Death

PEDIATRICS ◽  
2001 ◽  
Vol 107 (3) ◽  
pp. 530-536 ◽  
Author(s):  
C. Carroll-Pankhurst ◽  
E. A. Mortimer Jr
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Age At Death

Postnatal Growth Preceding Sudden Infant Death Syndrome

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 456-461
Author(s):  
John G. Brooks ◽  
Ruth E. Gilbert ◽  
Peter J. Flemming ◽  
Peter J. Berry ◽  
Jean Golding
Keyword(s):  
Growth Rate ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Final Analysis ◽  
Sudden Infant Death ◽  
Postnatal Growth ◽  
Bottle Feeding ◽  
Sudden Infant ◽  
Age At Death ◽  
The Mean

Objective. To compare postnatal growth preceding the sudden infant death syndrome (SIDS) with that of age matched controls. Design. Retrospective case-control study. Each SIDS victim was matched with two controls on date of parental interview, postnatal age, and neighborhood. Clinical and demographic data were collected by parental interview and by review of medical records, and interval body weights were obtained from health visitors' records. Study population. All infants dying of SIDS between 1 May, 1987 and 30 April, 1989 in a geographically defined region consisting of four health districts in Avon and North Somerset in southwest England. Seventy-eight of the 99 SIDS victims and 139 of 156 control infants were included in the final analysis. Results. There was no significant difference between SIDS victims and the controls in either of the two indices of postnatal growth which were analyzed. The mean growth rates (± 1 SEM) between birth and the last live weight (age equivalent weight for control infants) were 27.1 ± 1.0 g/day for the SIDS cases and 28.3 ± 1.5 g/day for the control infants. The mean growth rate (± 1 SEM) between the last two live weights were 31.5 ± 2.9 and 24.9 ± 2.1 g/day for the SIDS and control infants, respectively. Stratification of the infants by sex, gestational age, maternal smoking during pregnancy, breast versus bottle feeding, or age at death, did not result in any significant differences between SIDS and controls in either of the indices of postnatal growth rate. The 20 SIDS cases which were excluded from the final analysis did not differ from 78 whose data was analyzed, with regard to established SIDS risk factors, age at death, or postmortem weight. Conclusions. No difference was found between the postnatal growth of SIDS victims and that of age matched control infants.

Unterschiede und Gemein-samkeiten zwischen plötzlichem Säuglingstod (SIDS), Münchhausen-Syndrom by proxy (MSBP) mit tödlichem Ausgang und Infantizid

2007 ◽  
Vol 35 (4) ◽  
pp. 237-246 ◽  
Author(s):  
Frank Häßler ◽  
Henryk Zamorski ◽  
Steffen Weirich
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Post Mortem ◽  
Plötzlicher Säuglingstod

Zusammenfassung: Einleitung: Plötzlicher Säuglingstod - sudden infant death syndrome (SIDS) - ist die häufigste Todesursache im ersten Lebensjahr. Er ist definiert als der plötzliche und unerwartete Tod eines Säuglings, welcher weder durch die Vorgeschichte noch durch post-mortem Untersuchungen erklärt werden kann. Die Inzidenz in der BRD hat von 1,7 auf 1000 Lebendgeburten im Jahre 1990 auf 0,62 im Jahre 2000 abgenommen. Hinter 5 bis 11% der SIDS Fälle verbergen sich Infantizide. Diese Kindstötungen können durch ein Münchhausen-Syndrom by proxy (MSBP) verursacht sein. MSBP ist eine Form der Kindesmisshandlung, bei der die Eltern bzw. Sorgeberechtigten über einen längeren Zeitraum Symptome oder Krankheiten ihres Kindes erfinden oder gar induzieren (provozieren), was dem Kind zweifelsfrei Schaden zufügt. Kasuistik: In einer Familie mit drei Kindern starb die jüngste Tochter im Alter von 17 Monaten an einer Apnoe-Attacke. Zuvor war sie 11mal stationär in den verschiedensten Kinderkliniken der Region behandelt worden, ohne dass die Eingangssymptome wie Krampfanfälle, Atemnotsyndrom und Durchfälle objektiviert werden konnten. Die rechtsmedizinisch toxikologische Untersuchung wies post mortem Koffein im Blut nach. Eine natürliche Todesursache bzw. ein Unfall schienen klinisch eher unwahrscheinlich. Schlussfolgerungen: Für die Unterscheidung zwischen SIDS, MSBP und Infantiziden sollte auf sich wiederholende Krankheitssymptome, häufige Krankenhausaufenthalte bzw. ambulante Vorstellungen, keine verifizierbare Diagnose, eine gewisse Therapieresistenz, unklare Krankheiten oder Todesfälle bei Geschwistern, wiederholte Vergiftungs- bzw. Erstickungserscheinungen geachtet werden. Die Differenzierung sollte sehr sorgfältig und tiefgründig erfolgen, da die zu ziehenden Konsequenzen von Fall zu Fall variieren und weitreichend sein können.

Targeted Metabolic Profiling of Post-Mortem Brain from Infants Who Died from Sudden Infant Death Syndrome

2017 ◽  
Vol 16 (7) ◽  
pp. 2587-2596 ◽  
Author(s):  
Stewart F. Graham ◽  
Onur Turkoglu ◽  
Praveen Kumar ◽  
Ali Yilmaz ◽  
Trent C. Bjorndahl ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Metabolic Profiling ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Post Mortem ◽  
Post Mortem Brain

scholarly journals Post Mortem Neopterin Concentrations in Sudden Infant Death Syndrome (SIDS)

Pteridines ◽  
1990 ◽  
Vol 2 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Edda Ambach ◽  
Wolfgang Tributsch ◽  
Dietmar Fuchs ◽  
Arno Hausen ◽  
Gilbert Reibnegger ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Post Mortem

Post-mortem MRI reveals CPT2 deficiency after sudden infant death

2010 ◽  
Vol 169 (12) ◽  
pp. 1561-1563 ◽  
Author(s):  
Karim Bouchireb ◽  
Anne-Marie Teychene ◽  
Odile Rigal ◽  
Pascale de Lonlay ◽  
Vassili Valayannopoulos ◽  
...  
Keyword(s):  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Post Mortem

Myocarditis Misdiagnosed as Sudden Infant Death Syndrome (SIDS)

1997 ◽  
Vol 37 (1) ◽  
pp. 16-18 ◽  
Author(s):  
Anat Shatz ◽  
Jehuda Hiss ◽  
Baruch Arensburg
Keyword(s):  
Young Adults ◽  
Retrospective Study ◽  
Sudden Infant Death ◽  
Control Group ◽  
Sudden Infant ◽  
Post Mortem ◽  
Vocal Cords ◽  
Myocardial Diseases ◽  
Basement Membrane Thickening ◽  
Reported Study

In a retrospective study spanning five years, the histologic sections of 35 autopsies of infants diagnosed as SIDS victims were reviewed. Based on a recently reported study in which findings on marked basement membrane thickening (BMT) in the true vocal cords was suggested as a pathognomonic marker of SIDS, we expected to find BMT in all these cases. However, in seven of the reviewed autopsies (20%) no BMT was detected. Examination of new histologic sections of all the victims revealed myocarditis in these seven cases. In a control group (n=18) of children with known cause of death, neither BMT nor myocarditis were found. The incidence of myocardial diseases in infants and young adults (20% and 22% respectively) reported in the literature indicates that myocarditis is not a rare cause of sudden death in infants. Therefore, in SIDS-suspected cases a meticulous post-mortem microscopic examination of the heart should be carried out, especially whenever BMT of the vocal cords is absent.

Post-mortem analysis for two prevalent β-oxidation mutations in sudden infant death

2007 ◽  
Vol 49 (6) ◽  
pp. 883-887 ◽  
Author(s):  
ZI YANG ◽  
PATRICK E LANTZ ◽  
JAMAL A IBDAH
Keyword(s):  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Post Mortem

scholarly journals Primary Cardiac Fibroma and Cardiac Conduction System Alterations in a Case of Sudden Death of a 4-month-old Infant

2013 ◽  
Vol 7 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Donatella Mecchia ◽  
Anna Maria Lavezzi ◽  
Luigi Matturri
Keyword(s):  
Sudden Death ◽  
Good Health ◽  
Sudden Infant Death ◽  
Conduction System ◽  
Cardiac Conduction ◽  
Cardiac Conduction System ◽  
Sudden Infant ◽  
Post Mortem ◽  
Cardiac Fibroma ◽  
Fibrous Body

A 4-month-old female infant considered to be in good health died suddenly and unexpectedly. Post- mortem examination was requested, with clinical diagnosis of sudden infant death syndrome. At autopsy the infant was described in good health. Histo- logical examination of the heart found a cardiac fibroma compressing the atrio-ventricular node and the examination of the cardiac conduction system showed an accessory fiber of Mahaim (nodo-ventricular) and cartilaginous metaplasia of the cardiac fibrous body. Probably the concomitant presence of cardiac conduction system abnormalities and a septal fibroma, compressing the atrio-ventricular node, could have an important role in causing the sudden death.

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