Hypertrophic Cardiomyopathy with Shared Morphology in Identical Twins: A Case Report

2002 ◽  
Vol 47 (3) ◽  
pp. 64-65 ◽  
Author(s):  
L. Wylie ◽  
A. Ramage ◽  
D. C. MacLeod
Keyword(s):  
Case Report ◽  
Hypertrophic Cardiomyopathy ◽  
Identical Twins ◽  
Identical Twin ◽  
Asymmetric Septal Hypertrophy ◽  
Heterogeneous Expression ◽  
Septal Hypertrophy

We report the case of identical twin sisters, both with hypertrophic cardiomyopathy, and both found to have similar echocardiographic appearances in the form of asymmetric septal hypertrophy. This is unusual, in that published reports commonly describe the heterogeneous expression of this condition in twins.

The Cumulative Effects of the MYH7-V878A and CACNA1C-A1594V Mutations in a Chinese Family with Hypertrophic Cardiomyopathy

Cardiology ◽  
2017 ◽  
Vol 138 (4) ◽  
pp. 228-237 ◽  
Author(s):  
Bo Wang ◽  
Rui-Qi Guo ◽  
Jing Wang ◽  
Fan Yang ◽  
Lei Zuo ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Myocardial Fibrosis ◽  
Cumulative Effect ◽  
Left Ventricular ◽  
Chinese Family ◽  
St Segment ◽  
Asymmetric Septal Hypertrophy ◽  
Second Generation Sequencing ◽  
Septal Hypertrophy ◽  
Generation Sequencing

Aims: We investigated the pathogenesis of MYH7-V878A and CACNA1C-A1594V mutations in a Chinese family with hypertrophic cardiomyopathy. Methods: Clinical, electrocardiographic (ECG), echocardiographic, and cardiac magnetic resonance (CMR) examinations of members of a Chinese family were followed by exon and boarding intron analyses of 96 genes in the proband using second-generation sequencing. We confirmed the mutations by bidirectional Sanger sequencing in the members and in 300 healthy controls. Results: We detected MYH7-V878A and CACNA1C-A1594V mutations in this family. The members with both mutations showed inverted T-waves and ST-segment depression in ECG recordings, severe left ventricular (LV) hypertrophy in echocardiography, and myocardial fibrosis in CMR; subject II-11 did not show late gadolinium enhancement. Among those with only the MYH7-V878A mutation, subject III-7 showed abnormal ECG recordings, asymmetric septal hypertrophy, and myocardial fibrosis, and subjects II-13 and III-15 showed some abnormal repolarization, borderline LV wall thickness, and normal CMR findings. Those with only the CACNA1C-A1594V mutation showed nearly normal readings in all examinations. The members with both mutations displayed more severe LV hypertrophy and elevated LV filling pressure than those with 1 or no mutation (p < 0.05). Conclusion: Our results suggest that the pathogenesis of MYH7-V878A and CACNA1C-A1594V mutations may have a cumulative effect.

scholarly journals Asymmetric septal hypertrophy and hypertrophic cardiomyopathy.

Heart ◽  
1983 ◽  
Vol 49 (4) ◽  
pp. 309-316 ◽  
Author(s):  
R Emanuel ◽  
J Marcomichelakis ◽  
R Withers ◽  
K O'Brien
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Asymmetric Septal Hypertrophy ◽  
Septal Hypertrophy

scholarly journals 3D Evaluation of Palatal Rugae in Identical Twins

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Emiliya Taneva ◽  
Carla Evans ◽  
Grace Viana
Keyword(s):  
Case Report ◽  
Treatment Planning ◽  
Three Dimensional ◽  
Monozygotic Twins ◽  
Forensic Odontology ◽  
Identical Twins ◽  
Identical Twin ◽  
Dental Arch ◽  
Palatal Rugae ◽  
3D Evaluation

The study of identical twins can point out potential limitations in biometrics and forensic odontology. This case report presents three-dimensional (3D) palatal rugae analysis in monozygotic twins utilizing digital models obtained directly by scanning the maxillary dental arch with the iTero® intraoral digital scanner. The results show that the rugae patterns contain related but not identical features between the pair of identical twins. Dental study models taken on a regular basis for diagnosis and treatment planning in dentistry include the palatal rugae, which could be valuable to forensics in identical twin identification cases.

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