Plasma Lipoprotein Lipase Activity in Primary Type IV Hyperlipoproteinaemia

1972 ◽  
Vol 17 (6) ◽  
pp. 214-216 ◽  
Author(s):  
J. J. R. Weir ◽  
D. Cox ◽  
J. H. Moore ◽  
T. D. V. Lawrie
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Normal Subjects ◽  
Plasma Lipoprotein ◽  
Plasma Samples ◽  
Lipoprotein Lipase Activity ◽  
Type Iv ◽  
Normal Individuals ◽  
Heparin Plasma ◽  
Primary Type

Lipoprotein lipase activity has been measured in both pre- and post-heparin plasma samples from 6 patients with Primary Type IV hyperlipoproteinaemia and from 6 normal subjects. Post-heparin lipoprotein lipase activity was of the same order in plasma from both groups. Appreciable activity was, however, noted in plasma collected from the Type IV patients prior to administration of heparin. Lipase activity was minimal in such samples from normal individuals.

scholarly journals Plasma Lipoprotein Lipase Activity and Lipoprotein Lipase Activator in Type IV Hyperlipidemia

1980 ◽  
Vol 7 (4) ◽  
pp. 797-799
Author(s):  
Nobuhiro YAMADA ◽  
Toshio MURASE ◽  
Yasuo AKANUMA ◽  
Hiroshige ITAKURA ◽  
Kinori KOSAKA
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Plasma Lipoprotein ◽  
Lipoprotein Lipase Activity ◽  
Type Iv

Post-Heparin Plasma Lipoprotein Lipase and Hepatic Lipase in Normal Subjects and in Patients with Hypertriglyceridaemia: Correlations to Sex, Age and Various Parameters of Triglyceride Metabolism

1976 ◽  
Vol 50 (4) ◽  
pp. 249-260 ◽  
Author(s):  
J. K. Huttunen ◽  
C. Ehnholm ◽  
M. Kekki ◽  
E. A. Nikkilä
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Hepatic Lipase ◽  
Serum Triglyceride ◽  
Normal Subjects ◽  
Plasma Lipoprotein ◽  
Serum Triglycerides ◽  
Serum Triglyceride Concentration ◽  
Heparin Plasma ◽  
The Mean

1. A selective immunochemical method was used to measure post-heparin plasma lipoprotein lipase and hepatic lipase activity in eighty-two normal subjects and in twenty patients with type IIb, IV or V hypertriglyceridaemia. In twenty-six normal subjects the activity of post-heparin plasma lipases was compared with the kinetic parameters of endogenous plasma triglyceride metabolism. 2. The activity of post-heparin lipoprotein lipase was significantly higher in normal females than in males, whereas the activity of hepatic lipase showed an opposite sex ratio. The activity of lipoprotein lipase decreased with age both in males and females, whereas no significant age variation was observed in the activity of hepatic lipase. 3. In normal subjects a highly significant negative correlation was present in both sexes between the activity of post-heparin plasma lipoprotein lipase and fasting serum triglyceride concentration, but not between the activity of post-heparin hepatic lipase and serum triglycerides. 4. The fractional removal rate of endogenous triglycerides was positively correlated to the activity of lipoprotein lipase but not to the activity of hepatic lipase. No relationship was found between the activities of post-heparin plasma lipases and the absolute turnover of serum triglycerides. 5. The mean activity of post-heparin plasma lipoprotein lipase was significantly lower in subjects with hyperprebetalipoproteinaemia than in normal individuals. However, many hypertriglyceridaemic patients had lipoprotein lipase within the normal range and there was no correlation between serum triglyceride concentration and the activity of post-heparin lipases. 6. All three patients with fasting chylomicronaemia had low post-heparin lipoprotein lipase activity. Several subjects with high post-heparin plasma hepatic lipase activity were present in the group with hyperprebetalipoproteinaemia, but the mean value of the hepatic lipase was not significantly different from normal.

scholarly journals Increased plasma lipoprotein lipase activity in males with autism spectrum disorder

2020 ◽  
Vol 77 ◽  
pp. 101630
Author(s):  
Takaharu Hirai ◽  
Noriyoshi Usui ◽  
Keiko Iwata ◽  
Taishi Miyachi ◽  
Kenji J. Tsuchiya ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Autism Spectrum ◽  
Plasma Lipoprotein ◽  
Spectrum Disorder ◽  
Lipoprotein Lipase Activity

POST HEPARIN PLASMA LIPOPROTEIN LIPASE ACTIVITY IN THYROID DISEASE

1968 ◽  
Vol 59 (4) ◽  
pp. 555-563 ◽  
Author(s):  
Knut Kirkeby ◽  
Inger Bjerkedal
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Lipoprotein Lipase Activity ◽  
Heparin Plasma ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
High Triglyceride ◽  
Synthesis And Degradation

ABSTRACT Plasma post heparin lipoprotein lipase activity (LLA) has been studied in patients with hyper- and hypothyroidism and in rabbits made thyrotoxic with thyroxine. The hypothyroid patients had high triglyceride and low LLA values as compared with a control group of healthy subjects. Statistically highly significant negative correlation was found between the triglycerides in fasting patients and the post heparin LLA, indicating a causal relationship, possibly with disturbance of chylomicron degradation due to low LLA in the arterial wall. However, relatively low LLA values were also demonstrated in hyperthyroid patients as well as in rabbits following treatment with thyroxine for 3 weeks. A stimulating effect of the thyroid hormones on the synthesis and degradation of lipoprotein lipase may be a possible explanation for these apparently contradictory findings.

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