Effect of an antimitotic agent (cyclophosphamide) on post-heparin plasma lipoprotein lipase activity in rabbit

1985 ◽  
Vol 34 (19) ◽  
pp. 3597-3599 ◽  
Author(s):  
Anne-Marie Loudet ◽  
Nicole Dousset ◽  
Michel Carton ◽  
Louis Douste-Blazy
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Plasma Lipoprotein ◽  
Lipoprotein Lipase Activity ◽  
Antimitotic Agent ◽  
Heparin Plasma

Plasma Lipoprotein Lipase Activity in Primary Type IV Hyperlipoproteinaemia

1972 ◽  
Vol 17 (6) ◽  
pp. 214-216 ◽  
Author(s):  
J. J. R. Weir ◽  
D. Cox ◽  
J. H. Moore ◽  
T. D. V. Lawrie
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Normal Subjects ◽  
Plasma Lipoprotein ◽  
Plasma Samples ◽  
Lipoprotein Lipase Activity ◽  
Type Iv ◽  
Normal Individuals ◽  
Heparin Plasma ◽  
Primary Type

Lipoprotein lipase activity has been measured in both pre- and post-heparin plasma samples from 6 patients with Primary Type IV hyperlipoproteinaemia and from 6 normal subjects. Post-heparin lipoprotein lipase activity was of the same order in plasma from both groups. Appreciable activity was, however, noted in plasma collected from the Type IV patients prior to administration of heparin. Lipase activity was minimal in such samples from normal individuals.

scholarly journals Increased plasma lipoprotein lipase activity in males with autism spectrum disorder

2020 ◽  
Vol 77 ◽  
pp. 101630
Author(s):  
Takaharu Hirai ◽  
Noriyoshi Usui ◽  
Keiko Iwata ◽  
Taishi Miyachi ◽  
Kenji J. Tsuchiya ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Autism Spectrum ◽  
Plasma Lipoprotein ◽  
Spectrum Disorder ◽  
Lipoprotein Lipase Activity

POST HEPARIN PLASMA LIPOPROTEIN LIPASE ACTIVITY IN THYROID DISEASE

1968 ◽  
Vol 59 (4) ◽  
pp. 555-563 ◽  
Author(s):  
Knut Kirkeby ◽  
Inger Bjerkedal
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Lipoprotein Lipase Activity ◽  
Heparin Plasma ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
High Triglyceride ◽  
Synthesis And Degradation

ABSTRACT Plasma post heparin lipoprotein lipase activity (LLA) has been studied in patients with hyper- and hypothyroidism and in rabbits made thyrotoxic with thyroxine. The hypothyroid patients had high triglyceride and low LLA values as compared with a control group of healthy subjects. Statistically highly significant negative correlation was found between the triglycerides in fasting patients and the post heparin LLA, indicating a causal relationship, possibly with disturbance of chylomicron degradation due to low LLA in the arterial wall. However, relatively low LLA values were also demonstrated in hyperthyroid patients as well as in rabbits following treatment with thyroxine for 3 weeks. A stimulating effect of the thyroid hormones on the synthesis and degradation of lipoprotein lipase may be a possible explanation for these apparently contradictory findings.

Hyperlipidaemia in patients with hypopituitarism

1985 ◽  
Vol 110 (4) ◽  
pp. 456-460 ◽  
Author(s):  
Shun Ishibashi ◽  
Toshio Murase ◽  
Nobuhiro Yamada ◽  
Kunimi Tanaka ◽  
Fumimaro Takaku ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Plasma Lipoprotein ◽  
Endocrine Function ◽  
Lipoprotein Lipase Activity ◽  
Hepatic Triglyceride ◽  
Triglyceride Lipase ◽  
Sheehan's Syndrome ◽  
Hepatic Triglyceride Lipase

Abstract. Five patients with hypopituitarism due to Sheehan's syndrome showed hyperlipidaemia of various lipoprotein phenotypes. Postheparin plasma lipoprotein lipase activity was subnormal in 4 of the 5 patients and hepatic triglyceride lipase was markedly decreased in all patients studied. After supplementation of both corticosteroid and thyroid hormones, lipoprotein lipase activity was restored to normal within 2 months, while it took longer for hepatic triglyceride lipase to return to normal. Together with the normalization of the two lipase activities, hyperlipidaemia subsided. The findings suggest that reduced activities of the two lipases may, at least in part, account for the development of hyperlipidaemia in hypopituitarism. The study identifies a new group of patients with hyperlipidaemia secondary to a disorder in endocrine function.

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